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32
datasets available to search
ShareScore release 0.9.0
Dataset results
32 results for “midbrain organoids”
Single cell RNA sequencing analysis of midbrain organoids with SNCA gene triplication modeling key features of synuclienopathy
GEO Series GSE186780. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Cell cycle arrest of neural progenitors causes impaired dopaminergic neuronal differentiation in GBA associated Parkinson’s disease midbrain organoids
GEO Series GSE208784. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Production of highly uniform midbrain organoids from human pluripotent stem cells
GEO Series GSE236375. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Ventral midbrain-type neural stem/precursor cells (VM-NSCs) derived from human midbrain organoids as a stable source for treating symptoms of Parkinson’s disease
GEO Series GSE144062. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
SARS-CoV-2 induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures
GEO Series GSE225517. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Robust generation of honemogeneous midbrain organoids with in vivo–like cellular composition facilitates neurotoxin-based Parkinson’s disease modeling
GEO Series GSE122729. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Ventral midbrain-type neural stem/precursor cells (VM-NSCs) derived from human midbrain organoids as a stable source for treating symptoms of Parkinson’s disease
GEO Series GSE142505. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [MERFISH]
GEO Series GSE271118. synthetic construct; Homo sapiens. 21 samples. Type: Other.
The single cell transcriptomic profiling in iPSC derived Midbrain Organoid of POLG Disease
GEO Series GSE241743. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [scRNA-Seq]
GEO Series GSE271116. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Parkinson's disease midbrain organoids link GBA1 to Lewy pathology"
<p>This record contains data related to the article "Parkinson’s disease midbrain organoids link GBA1 to Lewy pathology".</p> <p><strong>Abstract</strong></p> <p>Aggregation of α-synuclein protein in “Lewy bodies” or “Lewy neurites” is a defining hallmark of Parkinson’s disease neuropathology. Mutations in <em>GBA1</em>, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in <em>GBA1</em> and α-synuclein pathology is yet to be determined, largely because of the absence of experimental models able to recapitulate the key neuropathological signatures of the disease. Here, we present an innovative midbrain organoid culture system derived from subjects with <em>GBA1</em>-related Parkinson’s disease as the first patient-based model able to reproduce fundamental neuropathological features of the disease. We show that retention of mutant glucocerebrosidase in the endoplasmic reticulum and increased glucosylceramide levels are determinants of α-synuclein aggregation into inclusions resembling Lewy bodies and Lewy neurites in both mono- and biallelic <em>GBA1</em> mutated midbrain organoids. In this process, the entity of glucocerebrosidase activity reduction acts as an accelerating factor in the progression of α-synuclein pathology by favoring the conversion of soluble α-synuclein to its insoluble forms. We provide evidence that α-synuclein extracted from Parkinson’s samples displays seeding activity <em>in vitro</em> and, following inoculation in unaffected organoids, propagates the pathology. Finally, we demonstrate pharmacological rescue of pathological phenotypes with molecules engaging in the glucocerebrosidase pathway, suggesting that midbrain organoids could represent valuable <em>in vitro</em> platforms for drug testing in Parkinson’s disease and potentially other Lewy body disorders still lacking a definitive therapy.</p> <p> </p>
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [RNA-Seq]
GEO Series GSE271115. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.