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Dataset results
32 results for “midbrain organoids”
Single-cell RNAseq of Day 49 midbrain organoids from healthy and alpha-synuclein triplication iPSC lines
<p>Unbiased single-cell RNAseq of Day 49 midbrain dopaminergic organoids (10x 3' v3) of the Patikas et al. publication.</p> <p> </p> <p>The mono-unt-celltypes.h5ad refers to the object shown at Fig 2A and contains 3 cell lines:</p> <ol> <li>KOLF2 ( Control cell line)</li> <li>SNCA-3x alpha Synuclein triplication Parkinson's Disease patient-derived iPSC line</li> <li>SNCA-corr (SNCA-3x isogenic control with the triplication mutation corrected)</li> </ol> <p>The all-celltypes.h5ad refers to the object shown at Fig 4 onwards and contains the 3 cell lines that are included in model-dataset.h5ad and 7 other single-cell RNAseq samples:</p> <ol> <li>SNCA-3x+KOLF2 (chimera organoid condition of SNCA-3x and KOLF2 of iPSCs grown together in a midbrain organoid)</li> <li>SNCA-corr+KOLF2 (chimera organoid condition of SNCA-corr and KOLF2 of iPSCs grown together in a midbrain organoid)</li> <li>5 paired rotenone conditions. For each condition (KOLF2, SNCA-3x, SNCA-corr, SNCA-3x+KOLF2, SNCA-corr+KOLF2) a paired condition with acute 24h rotenone treatment in an antioxidant-free medium.</li> </ol>
Brainwaves Monitoring via Human Midbrain Organoids Microphysiological Analysis Platform: MAP
<p>This dataset corresponds to the research manuscript entitled "Brainwaves Monitoring via Human Midbrain Organoids Microphysiological Analysis Platform: MAP"</p>
Tabular datasets for for Morrone Parfitt, G., Coccia, E., Goldman, C. et al. Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model. Nat Commun 15, 447 (2024). https://doi.org/10.1038/s41467-024-44732-2
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Single-cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures
GEO Series GSE192405. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (passages)
GEO Series GSE287566. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Generation and characterization of NGLY1 patient-derived midbrain organoids
GEO Series GSE224294. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the SNCA gene
GEO Series GSE278265. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single cell analysis of iPSC-derived midbrain organoids (GBA1 mutant and controls)
GEO Series GSE198033. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA sequencing profile of 60 day old human iPSC-derived midbrain organoids from healthy individual, Parkinson’s disease patient (Miro1 p.R272Q mutation) and its isogenic control
GEO Series GSE264097. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of healthy control organoids, a Parkinson disease patient specific midbrain organoid carrying a triplication in the SNCA gene and two healthy control organoids co-cultured with
GEO Series GSE275820. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Distinct microRNA signatures define sporadic PSP-RS and PD in patient-derived midbrain organoids
GEO Series GSE294029. Homo sapiens. 27 samples. Type: Non-coding RNA profiling by high throughput sequencing.
scRNAseq analysis of four populations sorted from midbrain organoids using Flow cytometry
GEO Series GSE226890. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Cell cycle arrest of neural progenitors causes impaired dopaminergic neuronal differentiation in GBA associated Parkinson’s disease midbrain organoids [2]
GEO Series GSE208783. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Modeling PD in midbrain-like organoids
GEO Series GSE127967. Homo sapiens. 5 samples. Type: Expression profiling by array.
Single cell profile of human iPSC-derived midbrain organoids from healthy individual, Parkinson disease patient harboring a Miro1R272Q mutation and its respective isogenic control
GEO Series GSE237133. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Cell cycle arrest of neural progenitors causes impaired dopaminergic neuronal differentiation in GBA associated Parkinson’s disease midbrain organoids [1]
GEO Series GSE208781. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
GEO Series GSE260711. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (timepoints)
GEO Series GSE269316. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
snRNA-Seq data of human iPSC-midbrain organoids without and with microglia
GEO Series GSE213288. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Modelling G2019S-LRRK2 sporadic Parkinson’s disease in 3D midbrain organoids
GEO Series GSE125234. Homo sapiens. 4 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.