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61 results for “multigeneration”
Data and code from: Multigenerational exposure to high-fat and high-sugar diets exacerbates reproductive distress in an insect model
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Data from: A multigenerational effect of parental age on offspring size but not fitness in common duckweed (Lemna minor)
Classic theories on the evolution of senescence make the simplifying assumption that all offspring are of equal quality, so that demographic senescence only manifests through declining rates of survival or fecundity. However, there is now evidence that, in addition to declining rates of survival and fecundity, many organisms are subject to age-related declines in the quality of offspring produced (i.e. parental age effects). Recent modelling approaches allow for the incorporation of parental age effects into classic demographic analyses, assuming that such effects are limited to a single generation. Does this 'single-generation' assumption hold? To find out, we conducted a laboratory study with the aquatic plant Lemna minor, a species for which parental age effects have been demonstrated previously. We compared the size and fitness of 423 lab-cultured plants (asexually-derived ramets) representing various birth orders, and ancestral 'birth-order genealogies'. We found that offspring size and fitness both declined with increasing 'immediate' birth order (i.e. birth order with respect to the immediate parent), but only offspring size was affected by ancestral birth order. Thus, the assumption that parental age effects on offspring fitness are limited to a single generation does in fact hold for L. minor. This result will guide theorists aiming to refine and generalise modelling approaches that incorporate parental age effects into evolutionary theory on senescence.
Data from: Behavioral changes in tadpoles after multigenerational exposure to an invasive intraguild predator
Prey subject to intraguild predation may face conflicting selective pressure on behavior, with competition favoring increased activity and predation favoring activity reduction. To discover how this evolutionary conflict might be resolved, we compared the behavior of tadpoles from four families drawn from different populations that had potentially co-evolved with an introduced intraguild predator for up to 90 years with the behavior of tadpoles from four families from unexposed populations. Intraguild prey were tadpoles of the declining California Red-legged Frog (Rana draytonii) and the intraguild predator was the invasive American Bullfrog (Lithobates catesbeianus), a voracious predator and strong competitor of other anurans. Limited evidence suggests that some native amphibians that have co-occurred with invasive predators for generations show adaptive behavioral responses to predator chemical cues. We tested whether R. draytonii larvae from families either allotopic or syntopic with bullfrogs would show responses to cues from overwintered bullfrog larvae. In the presence of cues, early-stage syntopic larvae decreased movement, consistent with an evolved innate defense, while allotopic larvae did not show behavioral changes. Later-stage syntopic larvae were generally more active than allotopic larvae, especially in the absence of cues, indicating a potential adaptive response to competition from bullfrog larvae. Increased activity appeared to be timed for when tadpoles became more resistant to predation. This is the first study to show changes in behavior across development consistent with complex selective pressure from an introduced intraguild predator. These findings have important implications for management of an endangered amphibian and a widely-introduced, invasive intraguild predator.
Raw data for the submitted manuscript: Multigenerational effects of agricultural microplastics on the mealworm Tenebrio molitor
<p>Dataset "Multigenerational effects of agricultural microplastics on the mealworm Tenebrio molitor" contains data on the moult, growth. development and survival of mealworms exposed to microplastics in food over two generations. Datasets are part of publication entitled: Multigenerational effects of agricultural microplastics on the mealworm Tenebrio molitor which is currently under review. </p> <p> </p>
Data from: Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory in Caenorhabditis elegans
The effects from multigenerational exposures to engineered nanoparticles (ENPs) in their pristine and transformed states are currently unknown despite such exposures being an increasingly common scenario in natural environments. Here, we examine how exposure over 10 generations affects the sensitivity of the nematode Caenorhabditis elegans to pristine and sulfidized Ag ENPs and AgNO3. We also include populations that were initially exposed over six generations but kept unexposed for subsequent four generations to allow recovery from exposure. Toxicity of the different silver forms decreased in the order AgNO3, Ag ENPs and Ag2S ENPs. Continuous exposure to Ag ENPs and AgNO3 caused pronounced sensitization (approx. 10-fold) in the F2 generation, which was sustained until F10. This sensitization was less pronounced for Ag2S ENP exposures, indicating different toxicity mechanisms. Subtle changes in size and lifespan were also measured. In the recovery populations, the sensitivity to Ag ENPs and AgNO3 resulting from the initial multigenerational exposure persisted. Their response sensitivity for all endpoints was most closely related to the last ancestral exposed generation (F5), rather than unexposed controls. The mechanisms of transgenerational transfer of sensitivity are probably organized through the epigenome, and we encourage others to investigate such effects as a priority for mechanistic toxicology.
No evidence for increased fitness of offspring from multigenerational effects of parental size or natal carcass size in the burying beetle Nicrophorus marginatus
<p>Multigenerational effects (often called maternal effects) are components of the offspring phenotype that result from the parental phenotype and the parental environment as opposed to heritable genetic effects. Multigenerational effects are widespread in nature and are often studied because of their potentially important effects on offspring traits. Although multigenerational effects are commonly observed, few studies have addressed whether they affect offspring fitness. In this study we assess the effect of potential multigenerational effects of parental body size and natal carcass size on lifetime fitness in the burying beetle, <i>Nicrophorus marginatus</i> (Coleoptera; Silphidae). Lifespan, total number of offspring, and number of offspring in the first reproductive bout were not significantly related to parental body size or natal carcass size. However, current carcass size used for reproduction was a significant predictor for lifetime number of offspring and number of offspring in the first brood. We find no evidence that multigenerational effects from larger parents or larger natal carcasses contribute to increased fitness of offspring.</p>
Formative Development of a Multigenerational eHealth Intervention for Grandparents and Grandchildren
ClinicalTrials.gov study NCT05906290. IPD Sharing: Not stated. Countries: 0. Publications: 1.
No evidence for increased fitness of offspring from multigenerational effects of parental size or natal carcass size in the burying beetle Nicrophorus marginatus
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Data from: Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory in Caenorhabditis elegans
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Data from: Behavioral changes in tadpoles after multigenerational exposure to an invasive intraguild predator
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Data from: A multigenerational effect of parental age on offspring size but not fitness in common duckweed (Lemna minor)
Open the record for dataset details and reuse information.
Multigenerational cell tracking of DNA replication and heritable DNA damage (bulk)
GEO Series GSE288485. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A deleterious impact on the C. elegans fertility over generation after a chronic exposure to ionizing irradiation: A multigenerational transcriptomic evidence
GEO Series GSE175918. Caenorhabditis elegans. 33 samples. Type: Expression profiling by high throughput sequencing.
In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [RNA-Seq]
GEO Series GSE280285. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
GEO Series GSE38813. Caenorhabditis elegans. 7 samples. Type: Non-coding RNA profiling by high throughput sequencing.
TCDD-mediated multigenerational effects in mice
GEO Series GSE220204. synthetic construct; Mus. 6 samples. Type: Non-coding RNA profiling by array.
Investigating multigenerational epigenetic adaptation of the hepatic wound-healing response
GEO Series GSE229524. Rattus norvegicus. 110 samples. Type: Expression profiling by high throughput sequencing.
Multigenerational effect of antibiotic tetracycline on transcriptional responses of D. magna and its relationship to higher levels of biological organizations
GEO Series GSE94439. Daphnia magna. 22 samples. Type: Expression profiling by array.
Multigenerational Proteolytic Inactivation of Restriction Upon Subtle Genomic Hypomethylation in Pseudomonas aeruginosa
GEO Series GSE301453. Pseudomonas aeruginosa PAO1. 18 samples. Type: Expression profiling by high throughput sequencing.
In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effects [array]
GEO Series GSE280162. Mus musculus. 22 samples. Type: Methylation profiling by array.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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