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160 results for “myocardium”
Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery
ClinicalTrials.gov study NCT00845364. IPD Sharing: Not stated. Countries: 1. Publications: 4.
X-ray patterns from porcine myocardium in the presence of mavacamten
<p>X-ray and mechanical experiments were performed using permeabilized porcine left ventricle wall muscle. The frozen muscle was thawed in skinning solution at room temperature before dissection into smaller strips and skinned at room temperature for 3 hours. Permeabilized fiber bundles were further dissected into preparations with a length of 4 mm with a diameter of 200 µm prior to attachment of aluminum T-clips to both ends for X-ray experiments. X-ray diffraction patterns were collected at BioCAT beamline on a MarCCD 165 detector (Rayonix Inc., Evanston IL) with a 1 s exposure time as a function of at seven different Ca2+ concentrations (pCa 8, pCa 6.4, pCa 6, pCa 5.8, pCa 5.6, pCa 5.3, and pCa 4.5) in the presence of 100 μM thin filament inhibitor (MYK-7660), and 2 μM of mavacamten ( in the mavacamten group)</p>
Impacts of a high fat diet on the metabolic profile and the phenotype of atrial myocardium in mice
<p>Aims: Obesity, diabetes and metabolic syndromes are risk factors of atrial fibrillation (AF). We tested the hypothesis that metabolic disorders have a direct impact on the atria favoring the formation of the substrate of AF.</p> <p>Methods & Results: Untargeted metabolomic and lipidomic analysis was used to investigate the consequences of a prolonged high fat diet (HFD) on mouse atria. Atrial properties were characterized by measuring mitochondria respiration in saponin-permeabilized trabeculae, by recording action potential with glass microelectrodes in trabeculae and ionic currents in myocytes using the perforated configuration of patch clamp technique and by several immuno-histological and biochemical approaches. After 16 weeks of HFD, obesogenic mice showed a vulnerability to AF. The atrial myocardium acquired an adipogenic and inflammatory phenotypes. Metabolomic and lipidomic analysis revealed a profound transformation of atrial energy metabolism with a predominance of long-chain lipid accumulation and beta-oxidation activation in the obese mice. Mitochondria respiration showed an increased use of palmitoyl-CoA as energy substrate. Action potentials were short duration and sensitive to the K-ATPdependent channel inhibitor, whereas K-ATP current was enhanced in isolated atrial myocytes of obese mouse.</p> <p>Conclusion:<em><strong> </strong></em>HFD transforms energy metabolism, causes fat accumulation, and induces electrical remodeling of the atrial myocardium of mice that become vulnerable to AF.</p> <p>Translational perspective: Understanding the link between metabolic diseases and atrial fibrillation is of major importance. One hypothesis claims that, in addition to shared co-morbidities, metabolic disorders favor the substrate of atrial fibrillation. Here we show that after prolonged high fat diet, the atrial myocardium becomes adipogenic, inflamed and vulnerable to atrial fibrillation. This tissue remodeling appears to result from an unbalance between uptake and oxidation of fatty acid resulting in long-chain lipid storage, activation metabolic-sensitive potassium channel and action potential shortening. Therefore, diet appears to be an important link between metabolic disorders and atrial fibrillation.</p>
Figure 1 from: Bak PG, Belenichev IF, Kucherenko LI, Abramov AV, Khromylоva OV (2021) Morpho-functional indicators changes of rats' myocardium in experimental doxorubicin-induced chronic heart failure and its pharmacological modulation with new 4-amino-1,2,4-triazole derivative. Pharmacia 68(4): 919-925. https://doi.org/10.3897/pharmacia.68.e75298
Figure 1 Hypothetical mechanism of the compound "Hypertril" positive effect on the morpho-functional parameters of rat cardiomyocytes in experimental doxorubicin-induced CHF.
Impacts of a high fat diet on the metabolic profile and the phenotype of atrial myocardium in mice
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Single-cell transcriptional analysis of human pluripotent stem cell-derived heart epicardium-myocardium organoids uncover principals of human epicardial-derived cells specification and coronary vascul
GEO Series GSE309829. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide gene expression analysis on remote non-infarcted myocardium after treatment with Valsartan in a mouse model of myocardial infarction
GEO Series GSE68426. Mus musculus. 17 samples. Type: Expression profiling by array.
Genomic instability in the naturally and prematurely aged myocardium [variants: data set 1]
GEO Series GSE124083. Mus musculus. 2 samples. Type: Genome variation profiling by high throughput sequencing.
Further inhibition of Histone H2A ubiquitination protects myocardium against ischemia/reperfusion injury through enhancing glycolysis and improving mitochondrial function via promoting Hsp27 expressio
GEO Series GSE225245. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
microRNA-seq from left ventricle myocardium superior (ENCSR200VKZ)
GEO Series GSE176601. Homo sapiens. 1 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Genomic instability in the naturally and prematurely aged myocardium [variants: data set 2]
GEO Series GSE129278. Mus musculus. 6 samples. Type: Other.
Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium
GEO Series GSE185634. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
miR-19 protects heart from myocardium infarction
GEO Series GSE126888. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
microRNA-seq from left ventricle myocardium inferior (ENCSR122DIB)
GEO Series GSE176680. Homo sapiens. 1 samples. Type: Non-coding RNA profiling by high throughput sequencing.
ATAC-seq from Right ventricle myocardium inferior (ENCSR855BMI)
GEO Series GSE170321. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
total RNA-seq from Right ventricle myocardium inferior (ENCSR015PUN)
GEO Series GSE174890. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
PRDM16 is required for proper specification of the working ventricular myocardium by suppressing alternative cardiomyocyte cell fates.
GEO Series GSE255382. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Microarray-Bioinformatics analysis of altered genomic expression profiles in the human fetal and infant myocardium
GEO Series GSE9135. Homo sapiens. 5 samples. Type: Expression profiling by array.
Single cell expression profiling of the mouse Sox17-null endocardium and myocardium at E8.5
GEO Series GSE125323. Mus musculus. 16 samples. Type: Expression profiling by array.
intact Hi-C from Right ventricle myocardium inferior (ENCSR921BHU)
GEO Series GSE238024. Homo sapiens. 3 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.