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105 results for “neuropeptide”
Data from: Neuropeptide signalling shapes feeding and reproductive behaviours in male C. elegans
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Resource limitation, intragroup aggression, and brain neuropeptide expression in a social wasp
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Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons
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Periprandial changes in brain serotonergic system and food intake related neuropeptides
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Data from: Circadian plasticity evolves through regulatory changes in a neuropeptide gene
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Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity levels and survival rate
<p>Neuropeptides are processed from larger preproproteins by a dedicated set of enzymes. The molecular and biochemical mechanisms underlying preproprotein processing and the functional importance of processing enzymes are well‐characterised in mammals, but little studied outside this group. In contrast to mammals, Drosophila melanogaster lacks a gene for carboxypeptidase E (CPE), a key enzyme for mammalian peptide processing. By combining peptidomics and neurogenetics, we addressed the role of carboxypeptidase D (dCPD) in global neuropeptide processing and selected peptide‐regulated behaviours in Drosophila. We found that a deficiency in dCPD results in C‐terminally extended peptides across the peptidome, suggesting that dCPD took over CPE function in the fruit fly. dCPD is widely expressed throughout the nervous system, including peptidergic neurons in the mushroom body and neuroendocrine cells expressing adipokinetic hormone. Conditional hypomorphic mutation in the dCPD‐encoding gene silver in the larva causes lethality, and leads to deficits in starvation‐induced hyperactivity and appetitive gustatory preference, as well as to reduced viability and activity levels in adults. A phylogenomic analysis suggests that loss of CPE is not common to insects, but only occurred in Hymenoptera and Diptera. Our results show that dCPD is a key enzyme for neuropeptide processing and peptide‐regulated behaviour in Drosophila. dCPD thus appears as a suitable target to genetically shut down total neuropeptide production in peptidergic neurons. The persistent occurrence of CPD in insect genomes may point to important further CPD functions beyond neuropeptide processing which cannot be fulfilled by CPE.</p>
Greater lactate accumulation does not alter peripheral concentrations of key appetite-regulating neuropeptides - Supplementary Data
<p>The manuscript "Greater lactate accumulation does not alter peripheral concentrations of key appetite-regulating neuropeptides" has been submitted to the Journal of Applied Physiology and the following data are supplementary data for this manuscript. Upon acceptance this record will be updated with the manuscript and journal information.</p>
Data from: Analysis of pigment-dispersing factor neuropeptides and their receptor in a velvet worm
<p>Pigment-dispersing factor neuropeptides (PDFs) occur in a wide range of protostomes including ecdysozoans (= molting animals) and lophotrochozoans (mollusks, annelids, flatworms, and allies). Studies in insects revealed that PDFs play a role as coupling factors of circadian pacemaker cells, thereby controlling rest-activity rhythms. While the last common ancestor of protostomes most likely possessed only one <i>pdf</i> gene, two <i>pdf</i> homologs, <i>pdf-I</i> and <i>pdf-II</i>, might have been present in the last common ancestors of Ecdysozoa and Panarthropoda (Onychophora + Tardigrada + Arthropoda). One of these homologs, however, was subsequently lost in the tardigrade and arthropod lineages followed by independent duplications of <i>pdf-I</i> in tardigrades and decapod crustaceans. Due to the ancestral set of two <i>pdf</i> genes, the study of PDFs and their receptor (PDFR) in Onychophora might reveal the ancient organization and function of the PDF/PDFR system in panarthropods. Therefore, we deorphanized the PDF receptor and generated specific antibodies to localize the two PDF peptides and their receptor in the onychophoran <i>Euperipatoides rowelli</i>. We further conducted bioluminescence resonance energy transfer (BRET) experiments on cultured human cells (HEK293T) using an Epac-based sensor (Epac-L) to examine cAMP responses in transfected cells and to reveal potential differences in the interaction of PDF-I and PDF-II with PDFR from <i>E. rowelli</i>. These data show that PDF-II has a tenfold higher potency than PDF-I as an activating ligand. Double immunolabeling revealed that both peptides are co-expressed in <i>E. rowelli</i> but their respective levels of expression differ between specific cells: some neurons express the same amount of both peptides, while others exhibit higher levels of either PDF-I or PDF-II. The detection of the onychophoran PDF receptor in cells that additionally express the two PDF peptides suggests autoreception, whereas spatial separation of PDFR- and PDF-expressing cells supports hormonal release of PDF into the hemolymph. This suggests a dual role of PDF peptides—as hormones and as neurotransmitters/neuromodulators—in Onychophora.</p>
Neuropeptides and Social Behavior
ClinicalTrials.gov study NCT01680718. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Intranasal Neuropeptide Y in Clinical Trial in Level Two Trauma Patients for PTSD and Acute Stress Disorder
ClinicalTrials.gov study NCT04071600. IPD Sharing: NO. Countries: 1. Publications: 3.
Neuropeptide Expression During the Ovarian Cycle and in Patients With PCOS
ClinicalTrials.gov study NCT05958914. IPD Sharing: NO. Countries: 1. Publications: 9.
A Dose Escalation Study of Intranasal Neuropeptide Y in Post Traumatic Stress Disorder (PTSD)
ClinicalTrials.gov study NCT01533519. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neuropeptide Y Regulates Neurogenic Pulp Inflammation
ClinicalTrials.gov study NCT06606236. IPD Sharing: NO. Countries: 1. Publications: 13.
Neuropeptides and Venous Pelvic Pain
ClinicalTrials.gov study NCT03921788. IPD Sharing: NO. Countries: 1. Publications: 3.
Neuropeptides in Human Reproduction
ClinicalTrials.gov study NCT01952782. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Anti-diuretic activity of a CAPA neuropeptide can compromise Drosophila chill tolerance
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Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity levels and survival rate
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Data from: Analysis of pigment-dispersing factor neuropeptides and their receptor in a velvet worm
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Neuropeptides from Sepia officinalis
<p>Dataset of transcripts annotated as neuropeptides and proteines predicted as precursors in de novo transcriptome of <em>Sepia officinalis</em> ( BioProject ID : PRJNA242869)</p> <p>Reference :</p> <p>Neuropeptidome of the Cephalopod <em>Sepia officinalis</em>: Identification, Tissue Mapping, and Expression Pattern of Neuropeptides and Neurohormones during Egg Laying.</p> <p>J Proteome Res. 2016 Jan 4;15(1):48-67. doi: 10.1021/acs.jproteome.5b00463. Epub 2015 Dec 18.<br> <br> Zatylny-Gaudin C(1)(2), Cornet V(1)(2), Leduc A(1)(2), Zanuttini B(3), Corre E(4), Le Corguillé G(4), Bernay B(1)(5), Garderes J(6), Kraut A(7)(8)(9), Couté Y(7)(8)(9), Henry J(1)(2)(5).<br> <br> Author information: <br> (1)Normandy University , F-14032 Caen, France.<br> (2)Normandy University , UMR BOREA MNHN, UPMC, UCBN, CNRS-7208, IRD-207, F-14032 Caen, France.<br> (3)Normandy University , GREYC, UMR CNRS 6072, F-14032 Caen, France.<br> (4)UPMC, CNRS, FR2424, ABiMS, Station Biologique, 29680 Roscoff, France.<br> (5)Post Genomic Platform PROTEOGEN, Normandy University , SF ICORE 4206, F-14032 Caen, France.<br> (6)Center for Marine Research, "Ruder Boskovic" Institute , HR-52210 Rovinj, Croatia.<br> (7)Univ. Grenoble Alpes , iRTSV-BGE, F-38000 Grenoble, France.<br> (8)CEA, iRTSV-BGE, F-38000 Grenoble, France.<br> (9)INSERM, BGE, F-38000 Grenoble, France.</p>
The neuropeptide substance P regulates aldosterone secretion in human adrenals
<p>Excel file of data demonstrating in vitro that the neuropeptide Substance P regulates aldosterone secretion in the human adrenal.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.