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128
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ShareScore release 0.9.0
Dataset results
128 results for “non-human primate”
Micro-anatomic alterations of the placenta in a non-human primate model of gestational protein-restriction
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Data from: A collection of non-human primate computed tomography scans housed in MorphoSource, a repository for 3D data
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Data from: DNA indicative of human bocaviruses detected in non-human primates in the Democratic Republic of the Congo
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Data from: Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is currently considered the pivotal pathological event. To better understand the progression of PD and improve treatment management, defining the disease on a structural basis and expanding brain analysis to extra-nigral structures is indispensable. The anatomical complexity and the presence of neuromelanin, make the use of non-human primates an essential element in developing putative imaging biomarkers of PD. To this end, ex vivo T2-weighted magnetic resonance images were acquired from control and 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated marmosets. Volume measurements of the caudate, putamen, and substantia nigra indicated significant atrophy and cortical thinning. Tensor-based morphometry provided a more extensive and hypothesis free assessment of widespread changes caused by the toxin insult to the brain, especially highlighting regional cortical atrophy. The results highlight the importance of developing imaging biomarkers of PD in non-human primate models considering their distinct neuroanatomy. It is essential to further develop these biomarkers in vivo to provide non-invasive tools to detect pre-symptomatic PD and to monitor potential disease altering therapeutics.
Non-human primate white matter development during the first year of life as assessed by diffusion tensor imaging and quantitative relaxometry
<p>In this project, we use diffusion tensor imaging (DTI) and quantitative relaxometry (QR) metrics to assess longitudinal changes in white matter (WM) throughout the postnatal rhesus macaque brain across the first year of life. DTI and QR metrics are measured at 3, 7, 13, 25, and 53 weeks of age in each of 35 non-human primates (NHPs) in this sample, for a total 175 datapoints (i.e., scans). Leveraging a previously published NHP WM atlas (Adluru et al., 2012; Zakszewski et al., 2014), we assess WM microstructure in 76 WM regions across the brain. DTI metrics include fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD); the QR metric assessed is the longitudinal relaxation rate (qR<sub>1</sub>). These longitudinal data enable the direct comparison of DTI and QR metrics in very early life on a within-subject level, as well as robust, multimodal modeling of WM growth in infancy, providing insights into early postnatal neurodevelopment that may have important implications neuropsychiatric and neurodevelopmental disorders in childhood.</p>
Fig. 3 in Differentiation of Trichuris species eggs from non-human primates by geometric morphometric analysis
Fig. 3. Factor map corresponding to Trichuris sp. eggs derived from different host primate species: macaque (M. sylvanus), colobus (C. g. kikuyensis), grivets (C. aethiops) and the Brazza's monkey (C. neglectus) from zoos in Spain. Samples are projected onto the first (PC1, 61%) and second (PC2, 18%) principal components. Each group is represented by its perimeter. Circles represent the centroid in each community.
Raw data accompanying "Arousal effects on oscillatory dynamics in the non-human primate brain"
<p>Raw local field potentials in two NHPs during eyes closed, low saccade, and high saccade task-free activity.</p> <p>Data and code to produce key figures. </p>
Data from: Cultural evolution of systematically structured behaviour in a non-human primate
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Non-human primate white matter development during the first year of life as assessed by diffusion tensor imaging and quantitative relaxometry
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Data from: Baby on board: olfactory cues indicate pregnancy and fetal sex in a non-human primate
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Data from: Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson’s disease
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Targeted Cortical Reorganization using Optogenetics in Non-human primates: Electrocorticography in Sensorimotor Cortex during Optogenetic Stimulation
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Gene Expression Profiling in Non-Human Primate Ileum after Total-Body Irradiation
GEO Series GSE74109. Macaca mulatta. 24 samples. Type: Expression profiling by array.
scRNA-seq profiling of lymph node activation in non-human primate Rhesus macaques by aluminum hydroxide and saponin adjuvant SMNP
GEO Series GSE264685. Macaca mulatta. 7 samples. Type: Expression profiling by high throughput sequencing.
Hyperandrogenemia and western-style diet act synergistically on transcription and DNA methylation in visceral adipose tissue of a non-human primate model [RRBS]
GEO Series GSE124708. Macaca mulatta. 24 samples. Type: Methylation profiling by high throughput sequencing.
HIV broadly neutralizing antibody precursors induced to the Apex epitope in non-human primates
GEO Series GSE304129. Macaca mulatta. 36 samples. Type: Expression profiling by high throughput sequencing; Other.
Gene Expression Profiling in Non-Human Primate Jejunum, Ileum and Colon after Total-Body Irradiation
GEO Series GSE74110. Macaca mulatta. 72 samples. Type: Expression profiling by array.
Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans
GEO Series GSE182211. Macaca nemestrina; Macaca fascicularis; Homo sapiens; Mus musculus. 5552 samples. Type: Expression profiling by high throughput sequencing.
Single dose of CD137-Antibody Drug Conjugate protects non-human primate allogeneic HCT recipients against acute GVHD
GEO Series GSE298158. Homo sapiens. 70 samples. Type: Expression profiling by high throughput sequencing.
Multivalent Influenza DNA vaccine induces cross-reactive polyfunctional T lymphocytes and promotes rapid clearance of heterologous challenge strain in non-human primates
GEO Series GSE77824. Macaca mulatta; Macaca fascicularis. 34 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.