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66
datasets available to search
ShareScore release 0.9.0
Dataset results
66 results for “novel pathogens”
Data from: Ultrafast evolution and loss of CRISPRs following a host shift in a novel wildlife pathogen, Mycoplasma gallisepticum
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Data from: Adaptive potential of ash (Fraxinus excelsior) populations against the novel emerging pathogen Hymenoscyphus pseudoalbidus
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Data from: Adaptive variation for growth and resistance to a novel pathogen along climatic gradients in a foundation tree
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Contrasting impacts of a novel specialist vector on multi-host viral pathogen epidemiology in wild and managed bees
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Data from: Emergence of novel fungal pathogens by ecological speciation: importance of the reduced viability of immigrants
Expanding global trade and the domestication of ecosystems have greatly accelerated the rate of emerging infectious fungal diseases, and host-shift speciation appears to be a major route for disease emergence. There is therefore an increased interest in identifying the factors that drive the evolution of reproductive isolation between populations adapting to different hosts. Here, we used genetic markers and cross-inoculations to assess the level of gene flow and investigate barriers responsible for reproductive isolation between two sympatric populations of Venturia inaequalis, the fungal pathogen causing apple scab disease, one of the fungal populations causing a recent emerging disease on resistant varieties. Our results showed the maintenance over several years of strong and stable differentiation between the two populations in the same orchards, suggesting ongoing ecological divergence following a host-shift. We identified strong selection against immigrants (i.e. host-specificity) from different host varieties as the strongest and likely most efficient barrier to gene flow between local and emerging populations. Cross-variety disease transmission events were indeed rare in the field and cross-inoculation tests confirmed high host specificity. Because the fungus mates within its host after successful infection and because pathogenicity-related loci prevent infection of non-host trees, adaptation to specific hosts may alone maintain both genetic differentiation between and adaptive allelic combinations within sympatric populations parasitizing different apple varieties, thus acting as a "magic trait". Additional intrinsic and extrinsic post-zygotic barriers might complete reproductive isolation and explain why the rare migrants and F1 hybrids detected do not lead to pervasive gene flow across years.
A novel genome-wide association approach reveals wheat pathogen genes involved in host specialization
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Data from: Emergence of novel fungal pathogens by ecological speciation: importance of the reduced viability of immigrants
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Novel insights into the role of the histone variant H2A.Z in the plant pathogen Fusarium fujikuroi [RNA-seq]
GEO Series GSE237762. Fusarium fujikuroi. 10 samples. Type: Expression profiling by high throughput sequencing.
A non-Dicer RNase III and four other novel factors required for RNAi-mediated transposon suppression in the human pathogenic yeast C. neoformans
GEO Series GSE128009. Cryptococcus neoformans. 48 samples. Type: Expression profiling by high throughput sequencing; Other; Non-coding RNA profiling by high throughput sequencing.
Expansion of a pivotal functional genomics resource identifies novel regulators of temperature-dependent fitness in the fungal pathogen Candida albicans
GEO Series GSE294776. Candida albicans. 24 samples. Type: Expression profiling by high throughput sequencing.
F2833 scRNA-seq data for manuscript "Therapeutic vaccine containing a novel liposomal adjuvant shifts pathogenic Th17 cells into a Tr1-like phenotype"
GEO Series GSE240801. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Pathogenicity of genomic duplications is determined by formation of novel chromatin domains (neo-TADs)
GEO Series GSE78109. Mus musculus; Homo sapiens. 48 samples. Type: Other; Expression profiling by high throughput sequencing.
Emerging Aeromonas enteric infections: their association with inflammatory bowel disease and novel pathogenic mechanisms
GEO Series GSE222117. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Thymus Transcriptome Reveals Novel Pathways in Response to Avian Pathogenic Escherichia coli (APEC) Infection
GEO Series GSE69014. Gallus gallus. 24 samples. Type: Expression profiling by high throughput sequencing.
A novel hybrid two-component system Lvr mediates virulence and global regulation in pathogenic Leptospira
GEO Series GSE79107. Leptospira interrogans serovar Manilae. 6 samples. Type: Expression profiling by high throughput sequencing.
Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010)
GEO Series GSE55663. Aspergillus fumigatus. 12 samples. Type: Expression profiling by high throughput sequencing.
Pathogenicity of genomic duplications is determined by formation of novel chromatin domains (neo-TADs) [Hi-C]
GEO Series GSE78072. Mus musculus. 6 samples. Type: Other.
The transcription and translation landscapes during human cytomegalovirus infection reveal novel host-pathogen interactions
GEO Series GSE69906. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing; Other.
F2702 bulk RNA-seq data for manuscript "Therapeutic vaccine containing a novel liposomal adjuvant shifts pathogenic Th17 cells into a Tr1-like phenotype"
GEO Series GSE240800. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater
GEO Series GSE228220. wastewater metagenome. 239 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.