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1,311 results for “ocular”
Disease parameters following ocular herpes simplex virus type 1 infection are similar in male and female BALB/C mice
<p>Sex-related differences in the incidence or severity of infection have been described for multiple viruses. With herpes simplex viruses, the best example is HSV-2 genital infection where women have a higher incidence of infection and can have more severe infections than men. HSV-1 causes several types of infections including skin and mucosal ulcers, keratitis, and encephalitis in humans that do not appear to have a strong biological sex component. Given that mouse strains differ in their MHC loci it is important to determine if sex differences occur in multiple strains of mice. Our goal was to answer two questions: Are virus-related sex differences present in BALB/C mice and does virulence of the viral strain have an effect? We generated a panel of recombinant HSV-1 viruses with differing virulence phenotypes and characterized multiple clinical correlates of ocular infection in BALB/c mice. We found no sex-specific differences in blepharitis, corneal clouding, neurovirulence, and viral titers in eye washes. Sex differences in neovascularization, weight loss, and eyewash titers were observed for some recombinants, but these were not consistent across the phenotypes tested for any recombinant virus. Considering these findings, we conclude that there are no significant sex-specific ocular pathologies in the parameters measured, regardless of the virulence phenotype following ocular infection in BALB/c mice, suggesting that the use of both sexes is not necessary for the bulk of ocular infection studies.</p>
Phase 3 Trial of NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT04445519. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
ClinicalTrials.gov study NCT03524157. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety Study of Netarsudil 0.02% Ophthalmic Solution Compared to Ripasudil Hydrochloride Hydrate 0.4% Ophthalmic Solution in Japanese Subjects With Primary Open Angle Glaucoma or Ocular H
ClinicalTrials.gov study NCT04620135. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT01241240. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT02247804. IPD Sharing: Not stated. Countries: 14. Publications: 2.
Study Comparing the Safety and Efficacy of BOL-303259-X to Latanoprost in Subjects With Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT01223378. IPD Sharing: NO. Countries: 1. Publications: 1.
Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery
ClinicalTrials.gov study NCT01847638. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessment of Fluticasone Propionate on Ocular Allergy Symptoms
ClinicalTrials.gov study NCT01817790. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Rhopressa® for the Reduction of Elevated Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension in a Real-world Setting
ClinicalTrials.gov study NCT03808688. IPD Sharing: NO. Countries: 1. Publications: 1.
A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab
ClinicalTrials.gov study NCT02859441. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular Hypertension
ClinicalTrials.gov study NCT01157364. IPD Sharing: NO. Countries: 10. Publications: 2.
Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT02674854. IPD Sharing: NO. Countries: 1. Publications: 2.
Efficacy and Systemic Safety of Netarsudil 0.01%, 0.02%, 0.04% Relative to Placebo in Subjects With Open-angle Glaucoma or Ocular Hypertension in Japan
ClinicalTrials.gov study NCT03844945. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Investigation of the Effect of Short-term Orthokeratology With Increased Compression Factor on Ocular Parameters
ClinicalTrials.gov study NCT02643875. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Use of Ocular Point of Care Ultrasound in Diagnosing Retinal Detachment in the Emergency Department
ClinicalTrials.gov study NCT03106025. IPD Sharing: YES. Countries: 1. Publications: 13.
Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT02558400. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension
ClinicalTrials.gov study NCT02507687. IPD Sharing: YES. Countries: 12. Publications: 2.
"Efficacy and Safety of Brimonidine Tartrate Preservative-Free Formulation in Adults With Ocular Redness"
ClinicalTrials.gov study NCT05360784. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery
ClinicalTrials.gov study NCT07067294. IPD Sharing: YES. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.