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ShareScore release 0.9.0
Dataset results
60 results for “optic neuritis”
Initial Clinical Presentation of Inflammatory Optic Neuritis Associated or Not With Autoantibodies Anti-Myelin-oligodendrocyte-glycoprotein
ClinicalTrials.gov study NCT03345537. IPD Sharing: NO. Countries: 1. Publications: 15.
Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial
ClinicalTrials.gov study NCT01962571. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis
ClinicalTrials.gov study NCT02220244. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Data from: Optical coherence tomography is highly sensitive in detecting prior optic neuritis
Objective: To explore sensitivity of optical coherence tomography (OCT) in detecting prior unilateral optic neuritis. Methods: Retrospective, observational clinical study of all patients who presented from 1/1/14 to 6/1/17 with unilateral optic neuritis and OCT available at least three months after the attack. We compared OCT retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thicknesses between affected and unaffected contralateral eyes. We excluded patients with concomitant glaucoma or other optic neuropathies. Based on analysis of normal controls, thinning was considered significant if RNFL was at least 9-µm or GCIPL was at least 6-µm less in affected eye compared to unaffected eye. Results: Fifty-one patients (18 male and 33 female) were included in the study. RNFL and GCIPL thicknesses were significantly lower in eyes with optic neuritis compared to unaffected eyes (p<0.001). RNFL was thinner by ≥9-µm in 73% of optic neuritis eyes compared to the unaffected eye. GCIPL was thinner by ≥6-µm in 96% of optic neuritis eyes. The sensitivity of OCT in detecting prior optic neuritis was 96% when using both average RNFL and GCIPL thicknesses. When using a threshold ≤1st percentile of age-matched controls, sensitivities were 37% for RNFL, 76% for GCIPL, and 78% for either GCIPL or RNFL thicknesses, each of which was lower than those calculated using the inter-eye difference as the threshold (p<0.05). Conclusions: OCT, especially in GCIPL, is a highly sensitive modality in detecting prior optic neuritis, which is made more robust by using inter-eye differences to approximate change.
Data from: Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders
Objective: To investigate, if neuromyelitis optica spectrum disorder (NMOSD) patients develop subclinical visual pathway impairment independent of acute attacks. Methods: 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 NMOSD patients from 16 centers were retrospectively evaluated for changes of P100-latencies and P100-N140-amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models. Results: The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951ms/year (N=101 eyes; SD=6.274; p=0.012) for the P100-latencies and -2.149µV/year (N=64 eyes; SD=5.013; p=0.005) for the P100-N140-amplitudes. For minimal VEP intervals of ≥12 months the RCL was +1.768ms/year (N=59 eyes; SD=4.558; p=0.024) and the RCA was -0.527µV/year (N=44 eyes; SD=2.123; p=0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689ms/year (N=16 eyes; SD=17.593; p=0.003) and -1.238µV/year (N=11 eyes; SD=3.708; p=0.308), respectively. Conclusions: This first longitudinal VEP study of NMOSD patients provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.
Atacicept in Subjects With Optic Neuritis
ClinicalTrials.gov study NCT00624468. IPD Sharing: Not stated. Countries: 11. Publications: 0.
Effect of Phenytoin on the Ganglion Cell Layer in Patients With Optic Neuritis
ClinicalTrials.gov study NCT02939937. IPD Sharing: YES. Countries: 1. Publications: 0.
Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography
ClinicalTrials.gov study NCT01465893. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fingolimod (FTY720) in Acute Demyelinating Optic Neuritis (ADON)
ClinicalTrials.gov study NCT01757691. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Data from: Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders
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Data from: Optical coherence tomography is highly sensitive in detecting prior optic neuritis
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Data from: Dichoptic metacontrast masking functions to infer transmission delay in optic neuritis
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Different immunological mechanisms between AQP4-positive and MOG-positive optic neuritis based on RNA-seq analysis of whole blood
GEO Series GSE226808. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
TLR-9 Antagonism in Steroid Resistant Optic Neuritis
ClinicalTrials.gov study NCT01424735. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Optic Neuritis and Ganglion Cell Layer
ClinicalTrials.gov study NCT02864134. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of Diagnostic Performances of 3D FLAIR, DIR and PSIR Sequences in Optic Neuritis
ClinicalTrials.gov study NCT06494228. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?
ClinicalTrials.gov study NCT03570385. IPD Sharing: NO. Countries: 1. Publications: 0.
Epidemiologic and Clinical Characteristics of Optic Neuritis in China
ClinicalTrials.gov study NCT04257734. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis
ClinicalTrials.gov study NCT03963310. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)
ClinicalTrials.gov study NCT04793087. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.