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56
datasets available to search
ShareScore release 0.9.0
Dataset results
56 results for “pKa*”
Elevated PKA activity at synapses and broad molecular disturbances in the striatum of Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder [bulk RNA-Seq]
GEO Series GSE306677. Mus musculus. 186 samples. Type: Expression profiling by high throughput sequencing.
Integrated ERK-PKA-YAP/TAZ-SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification
GEO Series GSE293205. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of wild typeHDAC1 and HDAC1_S434A Transcriptomes with or without PKA inhibitor H89 treatment
GEO Series GSE284216. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
SUL1 deficiency reduces PKA activity to increase replicative lifespan in yeast Saccharomyces cerevisiae
GEO Series GSE296216. Saccharomycotina. 11 samples. Type: Expression profiling by high throughput sequencing.
Diversely evolved xibalbin variants from remipede venom inhibit 3 potassium channels and activate PKA-II and Erk1/2 signalling
<p><span><strong>Background:</strong> </span><span>The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede <em>Xibalbanus tulumensis</em>, an underwater cave-dwelling crustacean, is the only crustacean for which a venom system has been described. Its venom contains several xibalbin peptides that have an inhibitor cysteine knot (ICK) scaffold.</span></p> <p><strong><span>Result:</span></strong><span><strong> </strong>Our screenings revealed that all tested xibalbin variants particularly inhibit potassium channels. Xib<sub>1</sub> and xib<sub>13</sub>, with their eight-cysteine domain similar to spider knottins also inhibit voltage-gated sodium channels. No activity was noted on calcium channels. Expanding the functional testing we demonstrate that xib<sub>1</sub> and xib<sub>13</sub> increase PKA-II and Erk1/2 sensitization signaling in nociceptive neurons, which may initiate pain sensitization. Our phylogenetic analysis suggests that xib<sub>13</sub> either originates from the common ancestor of pancrustaceans or earlier while xib<sub>1</sub> is more restricted to remipedes. The ten-cysteine scaffolded xib<sub>2</sub> emerged from xib<sub>1</sub>, a result that is supported by our phylogenetic and machine learning-based analyses.</span></p> <p><strong><span>Conclusions</span></strong><span><strong>: </strong>Our functional characterization of synthesized variants of xib<sub>1</sub>, xib<sub>2</sub>, and xib<sub>13</sub> elucidates their potential as inhibitors of potassium channels in mammalian systems. The specific interaction of xib<sub>2</sub> with Kv1.6 channels, which are relevant to treating variants of epilepsy, shows potential for further studies. At higher concentrations, xib1 and xib13 activate the kinases PKA-II and ERK1/2 in mammalian sensory neurons, suggesting pain sensitization and potential applications related to pain research and therapy. While tested insect channels suggest that all probably act as neurotoxins, the biological function of xib<sub>1</sub>, xib<sub>2,</sub> and xib<sub>13</sub> requires further elucidation. A novel finding on their evolutionary origin is the apparent emergence of </span><em><span>X. tulumensis</span></em><span>-specific xib<sub>2</sub> from xib<sub>1</sub>. Our study is an important cornerstone for future studies to untangle the origin and function of these enigmatic proteins as important components of remipede but also other pancrustacean and arthropod venoms.</span></p>
Role of ROS and cAMP-PKA Biomarkers in ADPKD
ClinicalTrials.gov study NCT07217158. IPD Sharing: NO. Countries: 1. Publications: 0.
Global regulatory roles of the cAMP/PKA pathway revealed by phenotypic, transcriptomic, and phosphoproteomic analyses in a null mutant of PKA catalytic subunit in Candida albicans
GEO Series GSE92621. Candida albicans. 3 samples. Type: Expression profiling by high throughput sequencing.
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease (RNA-Seq)
GEO Series GSE128522. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
PKA regulated genes in HEK293 cells
GEO Series GSE245789. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
PKA regulatory subunit Bcy1 couples growth, lipid metabolism, and fermentation during anaerobic xylose growth in Saccharomyces cerevisiae
GEO Series GSE220465. Saccharomyces cerevisiae. 30 samples. Type: Expression profiling by high throughput sequencing.
Expression data during differentiation from mouse embryonic stem cells with or without PKA activation
GEO Series GSE134618. Mus musculus. 9 samples. Type: Expression profiling by array.
Activation of GPCR-GNAS-PKA signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity
GEO Series GSE225553. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in Dictyostelium discoideum
GEO Series GSE97392. Dictyostelium discoideum. 48 samples. Type: Expression profiling by high throughput sequencing.
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease (ChIP-Seq)
GEO Series GSE128521. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity
GEO Series GSE283770. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Overexpression of PKA regulatory subunits in ovarian cancer cells
GEO Series GSE12854. Homo sapiens. 9 samples. Type: Expression profiling by array.
The nuclear Bile Acid Receptor FXR is a PKA- and FOXA2- sensitive Activator of Fasting Hepatic Gluconeogenesis [glucacon/GW4064]
GEO Series GSE113526. Mus musculus. 8 samples. Type: Expression profiling by array.
Activation of GPCR-GNAS-PKA signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity
GEO Series GSE214859. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
TORC1 and PKA dependent gene regulation
GEO Series GSE133591. Saccharomyces cerevisiae. 21 samples. Type: Expression profiling by array.
The PKA Pathway of Endometrial Stromal Fibroblasts Reveals Differentiation and Proliferative Potential in Endometriosis
GEO Series GSE17504. Homo sapiens. 20 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.