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18,654 results for “pain”
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
<p>The dataset (CWP_GWAS_EU_ANCESTRY_UKB.txt) contains summary statistics for discovery GWAS of chronic widespread pain based on northern Europeans from UK Biobank comprising 6,914 cases of chronic widespread musculoskeletal pain and 242,929 controls. The sensitivity GWAS (CWP_sensitivity_GWAS_EU_ANCESTRY_UKB.txt) dataset contains summary statistics derived from 6,914 cases of chronic widespread musculoskeletal pain and 223,606 controls. Methodological details available here, https://doi.org/10.1101/2020.11.30.20241000 </p> <p> </p> <p> </p> <p> </p>
Dataset and Code: Pain and sickness behavior associated with corneal lesions in dairy calves
<p>This is the dataset and code for the analysis of sickness behaviors in calves within corneal lesions (IBK or pinkeye). </p>
Image database to supplement "Paulus, F.M. et al. Pain empathy but not surprise in response to unexpected action explains arousal related pupil dilation." (VIPER database)
<p>This folder contains the 282 images of the "VIPER" database (visually-induced pain empathy repository) along with ratings of 24 independent raters. Details are described in the following publication:</p> <p>Paulus, F.M., Müller-Pinzler, L., Walper, D., Marx, S., Hamschmidt, L., Rademacher, L., Krach, S., Einhäuser, W. Pain empathy but not surprise in response to unexpected action explains arousal related pupil dilation.</p> <p>The material can be used for scientific purposes, provided this reference is appropriately cited. Please check the download site to get the up-to-date reference at the time of your publication.</p> <p> </p> <p>Conditions are identified by the filename of the image, which consists of the number of the scenario (1-83) and the condition identifier:<br> pain<br> neut(ral)<br> mism(atch)<br> tool<br> Note that the tool and the mismatch condition do not exist for all scenarios.</p> <p>The file ratings_viper.csv contains the ratings. Each image corresponds to a line, the columns are as follows:<br> Column 1: Filename of the image<br> Column 2: Scenario number<br> Column 3: condition<br> Columns 4 through 27: ratings of the 24 individuals (between 0 and 4, NaN if there was no rating recorded)</p> <p>The file thumbnail_viper.jpg provides an overview over all images in the database.</p> <p>For ease of download, the images are available as tar-archive (allImages_viper.tar) and as inidivual files.</p> <p> </p>
PAINS containing analog series
<p>The file contains analog series that consist exclusively of compounds with PAINS motifs and analog series that contain both PAINS and non-PAINS. For all 54,384 compounds ("cid(PubChem)") in these analog series their corresponding PAINS classes ("PAINS Class") and analog series ID ("ASs ID") are given. Compound IDs ("cid(PubChem)") refer to the original PubChem compound identifiers. All analog series are annotated as 'PAINS' or 'PAINS+non-PAINS' ("ASs Type") respectively to their overall composition. </p>
Sex-specific trunk movement coordination in participants with low-back pain and asymptomatic controls
<p>This is the data set and the code used for our publication. </p>
Cervical Proprioception, Postural Control, and Pain
<p>The dataset comprises demographic and clinical characteristics of two groups: 82 Rheumatoid Arthritis (RA) patients and 82 asymptomatic individuals. The RA patients have a mean age of 55.25 years (SD = 10.02), while the asymptomatic individuals have a mean age of 54.18 years (SD = 10.15), with both groups having an age range of 40-70 years. Gender distribution is identical, with 20% males and 80% females in each group. Marital status differs slightly; 36% of RA patients are single, and 66% are married, compared to 39% and 61% in the control group. Educational attainment shows 27% of RA patients completed high school, 49% have college degrees, and 24% hold graduate degrees, compared to 30%, 43%, and 27% in the control group. Employment status reveals 61% of RA patients are employed, 24% are unemployed, and 15% fall into other categories, similar to 63%, 22%, and 15% in the control group. </p>
Distinguishing between pan assay interference compounds (PAINS) that are promiscuous or represent dark chemical matter - data set and prediction models
<p>Data sets of promiscuous PAINS (PROM_PAINS) and dark chemical matter PAINS (DCM_PAINS) are provided and support vector machine models built on the basis of original and balanced training data (see readme.txt).<br> </p>
Dataset of the publication "Cross-sectional study of prevalence of dementia, behavioural symptoms, mobility, pain and other health parameters in nursing homes in Austria and the Czech Republic: results from the DEMDATA project"
<p>Dataset of the publication Stefanie R. Auer , Margit Höfler, Elisabeth Linsmayer, Anna Beránková, Doris Prieschl, Paulina Ratajczak,<br> Michal Šteffl and Iva Holmerová (2018) "Cross-sectional study of prevalence of dementia, behavioural symptoms, mobility, pain and other health parameters in nursing homes in Austria and the Czech Republic: results from the DEMDATA project"</p>
Insect Pain Database: Pain Scale
Open the record for dataset details and reuse information.
Dataset related to article: "Congenital insensitivity to pain a novel mutation affecting a U12-type intron causes multiple aberrant splicing of SCN9A"
<p>raw data related to article reported at title</p>
Health-related quality of life and musculoskeletal pain in health sciences university students
<p><strong>Purpose: </strong>To analyse the health-related quality of life and associated variables in health science university students. Secondly, to determine the prevalence of musculoskeletal pain and central sensitisation, and the differences by gender.</p> <p><strong>Methods: </strong>Cross-sectional study among health sciences university students, using anonymous, self-administered questionnaires (SF-12, Nordic Musculoskeletal Questionnaire (NMQ), Numeric Pain Rating Scale (NRS), Central Sensitisation Inventory (SCI)).</p> <p><strong>Results: </strong>Three hundred and thirty eight students were included (76.3% female; age 22.5±4.9 years). The mean SF-12 Physical Component Summary was higher than the mean of 50 in the Spanish adult population as a whole for both female and male students (54.6 vs. 55.9; p=0.02), whereas the mean SF-12 Mental Component Summary was lower than the population mean (36.7 vs. 42.8; p<0.001). These differences persisted when compared with age- and sex-matched population standardized scores.</p> <p>A high prevalence of musculoskeletal pain was observed, particularly in the back area. Pain was generalised, chronic, of moderate intensity, and more frequent in women.</p> <p>Variables associated with worse physical health were being female (B=-1.5; p=0.035), having a disability (B=-4.6; p<0.001), chronic musculoskeletal pain at any site (B=-2.1; p=0.001), and a score ≥40 on the SCI (B=-3.2: p<0.001). The only variable associated with poorer mental health was the SCI score.</p> <p><strong>Conclusion: </strong>Health sciences university students report a significant deterioration in mental health and a high prevalence of musculoskeletal pain, with symptoms of central sensitisation associated with poorer physical and mental health. Women have worse mental health and a higher prevalence, intensity and chronification of musculoskeletal pain.</p>
Mapping the neuroethological signatures of pain, analgesia and recovery in mice
<p><strong>Mapping the neuroethological signatures of pain, analgesia and recovery in mice.</strong><br> Repository containing datasets obtained for M. Bohic, L Pattison, et al. 2023. Neuron. </p> <p><strong>Abstract</strong><br> Ongoing pain is driven by direct activation of pain-sensing neurons and neuroimmune mediated sensitization. These heightened pain states alter physiology, reduce motor function, and affect motivation to engage in normal behaviors. The complexity of the pain state has evaded a comprehensive definition, especially in nonverbal animals. Here in mice, we capture the physiological state of sensitized neurons and use computational tools to automatically map behavioral signatures of evoked and spontaneous displays of pain at different time points for both an acute model of paw inflammatory pain and a chronic model of knee joint pain. First, retrograde labeling coupled with electrophysiology of neurons innervating injury sites revealed key time points corresponding to peripheral sensitivity in multiple pain models. Next, we used high-speed videography combined with supervised and unsupervised machine learning tools to uncover sensory-evoked defensive coping postures, unique to each pain condition. Using 3D pose analytics inspired by natural language processing, we identify movement sequences that correspond to robust representations of ongoing pain states. With this new analytical framework, we find that commonly used analgesics do not return an animal’s behavior to a pre-injury state. Instead, animals adopt a novel set of spontaneous behaviors that are maintained even after most evoked behavioral features of pain have resolved. Together, these findings reveal previously unidentified neuroethological signatures of pain and analgesia at timescales when inflammation induces heightened pain states and during recovery.</p>
GWAS Summary Statistics of 7 chronic pain types
<p>Summary Statistics obtained from .fastGWA files after running GWAS analyses using GCTA package for 7 chronic pain types: back, neck, hip, knee, facial and abdominal pain as well as chronic headaches.</p>
Result of COJO analysis on 7 chronic pain types
<p>JMA files were obtained from COJO analysis ran across 7 chronic pain types: neck, back, hip, knee, abdominal, and facial and headaches. I used the GCTA-COJO tool along with the summary statistics uploaded in this repository and a reference panel produced using our bgen files from UKB. There are only 6 files uploaded as there were no SNPs returned from the COJO analysis for the chronic facial pain phenotype.</p>
Fine mapping of 5 chronic pain types
<p>Fine mapping was run with CAUSALdb-finemapping-pip using clumped GWAS data of 5 chronic pain types: chronic neck, back, hip and knee pain and chronic headaches.</p>
Raw Data for Unpublished Study "Physiologically Induced State Anxiety Reduces Perceived Heat Pain in Healthy Subjects"
<p>Version hyper_v01_20231019</p><p>Authors: Alexandros Guekos, Madeleine Hau, Sabina Grob, Gil Sharvit, Petra Schweinhardt</p><p>The present data was collected from February 2022 to May 2023 for a study on the influence of hypercapnia on pain perception.</p><p>The results are to be published soon. A link to the manuscript will be provided.</p><p>Full details of the paradigm, the experimental setup, and the analysis will be given there. Therefore, the following description only summarizes the most important steps.</p><p>In total, 47 subjects (22 men and 25 women) participated in a single experimental session during which they inhaled two different air mixtures, one coresponding to regular room air (normocapnic air, 21% O2 and 0.04 CO2) and one with identical O2 concentration (21%) but 7.5% CO2 concentration (hypercapnic air) for about 13 minutes each. Starting condition, i.e. first mixture, was pseudorandomized across participants.</p><p>Each condition began with a task-free phase of 90s. Then, self-assessment manikin (SAM) ratings for valence and arousal had to be entered (10s) before the first heat stimulus. SAM ratings were prompted again in the middle of the condition, i.e. during the ninth interstimulus interval, and after rating the last, i.e. 18th stimulus. After the last stimulus, the body sensations questionnaire (BSQ) had to be filled in (60s). After a further 60s of task-free time the air mixture was switched and the entire procedure was repeated for the second condition.</p><p>Instructions for SAM were given before the start of the experiment (see SAM_instructions_final.pdf).</p><p>BSQ was obtained before the experiment as well (see paper version BSQ_new.pdf).</p><p>During inhalation participants received 18 painful heat stimuli of 6s each on three locations on the calf muscle. The stimuli were divided into low (6x), medium (6x), and high (6x). Stimulus temperature was determined based on the individual heat pain tolerance threshold (ToT), corresponding to roughly 95, 96.5, 98% ToT. ToT was determined as a mean of three method of limits beforehand.</p><p>Participants had to rate every stimulus on two scales, one for intensity and one for unpleasantness. The intensity scale ranged from 0 (no sensation) to 200 (maximum tolerable pain) with 100 being the individual pain threshold (HPT). The unpleasantness scale ranged from -100 (extremely unpleasant) to 100 (extremely pleasant) with 0 corresponding to neutral.</p><p>Both scales were presented as horizontal bars with anchors for the lowest, highest, quarter-, and mid-point values. Ratings had to be filled in using a mouse-controlled slider on the two scales displayed on the screen (see Ratings.png). The whole protocol was programmed and displayed with PsychoPy v3.2021.2.3 (Open Science Tools Ltd, Nottingham, UK). The total duration of each condition was approximately 13 minutes (778s).</p><p>During the whole experiment, physiological data was recorded. This included galvanic skin response from the toes (electrodes on biggest and middle toes, in muS), heart rate (three point measurement, in bpm), as well as exhaled O2 and C02 concentration (in %). Heart beat and end-tidal were directly calculated from the registered data during recording and saved with the data.</p><p>The study was funded by the Swiss National Science Foundation as part of a grant to PS (grant number 320030_179191/1).</p>
Ketamine for Pain in the Emergency Department
ClinicalTrials.gov study NCT03896230. IPD Sharing: NO. Countries: 1. Publications: 21.
Ketamine Infusion for Comorbid PTSD and Chronic Pain
ClinicalTrials.gov study NCT04322968. IPD Sharing: NO. Countries: 1. Publications: 6.
Mindfulness and Mechanisms of Pain Processing in Adults With Migraines
ClinicalTrials.gov study NCT02695498. IPD Sharing: YES. Countries: 1. Publications: 2.
Asian Phase 2 Study for Treatment of Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT01504412. IPD Sharing: YES. Countries: 3. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.