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34 results for “per- and polyfluoroalkyl substances”
Development of Chemical Categories for Per- and Polyfluoroalkyl Substances (PFAS) and the Proof-of-Concept Approach to the Identification of Potential Candidates for Tiered Toxicological Testing and Human Health Assessment
<p>Supplementary information for the manuscript and raw data files underpinning the analysis are available here as compressed tar files. </p> <p>Please cite: Patlewicz G., Judson R., Williams A. J., Butler T., Barone Jr. S ., Carstens K. E., Cowden J., Dawson J. L., Degitz S. , Fay K., Henry T. R., Lowit A., Padilla S., Paul Friedman K., Phillips M. B., Turk D., Wambaugh J., Wetmore B., Thomas R.S. Development of Chemical Categories for Per- and Polyfluoroalkyl Substances (PFAS) and the Proof-of-Concept Approach to the Identification of Potential Candidates for Tiered Toxicological Testing and Human Health Assessment. <em>Computational Toxicology</em> <strong>2024</strong> <a href="https://doi.org/10.1016/j.comtox.2024.100327" rel="nofollow">https://doi.org/10.1016/j.comtox.2024.100327</a></p>
A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS)
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Development and application of a high-throughput gene expression profiling of per- and polyfluoroalkyl substances (PFAS) in primary liver human spheroids to inform read-across
GEO Series GSE144775. Homo sapiens. 607 samples. Type: Expression profiling by high throughput sequencing.
Per- and Polyfluoroalkyl Substances Cause Changes in Gene Expression within HepG2 Cells Individually and as Equimolar Mixtures in Concentration-Response
GEO Series GSE266866. Homo sapiens. 96 samples. Type: Expression profiling by array.
Replacement Per and Polyfluoroalkyl Substance GenX Induces Fibroinflammatory Gene Expression in Primary Human Hepatocytes
GEO Series GSE187633. Homo sapiens. 5 samples. Type: Expression profiling by array.
Sperm production is comprised in mice exposed to environmentally relevant per- and polyfluoroalkyl substances (PFAS)
GEO Series GSE271479. Mus musculus. 19 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Points of departure for an algal species (Raphidocelis subcapitata) exposed to 22 per- and polyfluoroalkyl substances
GEO Series GSE269539. Raphidocelis subcapitata. 493 samples. Type: Expression profiling by high throughput sequencing.
Per- and Polyfluoroalkyl Substances Cause Changes in MicroRNA Expression within Extracellular Vesicles
GEO Series GSE200764. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Per- and polyfluoroalkyl substances (PFASs) exposure in melanoma patients: a retrospective study on prognosis and histological features
<p>Per- and polyfluoroalkyl substances (PFASs) are endocrine disrupting chemicals and previous studies showed that they could be associated with altered vitamin D levels. Since 1965, a massive environmental contamination by PFASs has occurred in North-eastern Italy. This study compared histopathology and prognosis between melanoma patients exposed (n=194) and unexposed (n=488) to PFAS. All patients were diagnosed and/or treated for melanoma at the Veneto Oncological Institute and the University Hospital of Padua (Italy) in 1998-2014. Patients were stratified according to the area of residency and the classification provided by the regional administration. Presence of mitoses was found in 70.5% of exposed patients and 58.7% of unexposed patients (p=0.005). Median follow-up was 90 months (IQR 59-136). 5-year overall survival was 83.7% in exposed patients and 88.0% in unexposed patients (p=0.20); 5-year disease-specific survival was 88.0% in exposed patients and 90.9% in unexposed patients (p=0.50); 5-year disease-free survival was 83.8% in exposed patients and 87.3% in unexposed patients (p=0.20). Our findings suggested that exposure to PFAS was associated with higher level of mitosis in melanoma patients, which may be related to the vitamin D deficiency induced by PFAS. Further studies are required to investigate this relationship and all effects of PFAS on prognosis.</p>
Identifying key events from Per- and Polyfluoroalkyl Substances exposure that influence larval zebrafish in light:dark assay using RNA-sequencing analysis of perfluorohexane-1-sulfonate (PFHxS)
GEO Series GSE190009. Danio rerio. 48 samples. Type: Expression profiling by high throughput sequencing.
Per- and polyfluoroalkyl substances (PFAS) suppress macrophage alternative activation to disrupt hepatic lipid metabolism [RNA-seq I]
GEO Series GSE284228. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Environmentally relevant concentrations of individual per- and polyfluoroalkyl substances (PFAS) and a PFAS mixture impact proliferation and gene transcription in a human myometrial cell line.
GEO Series GSE279836. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Identifying key events from Per- and Polyfluoroalkyl Substances exposure that influence larval zebrafish in light:dark assay using RNA-sequencing analysis of perfluorooctane sulfonic acid (PFOS)
GEO Series GSE190490. Danio rerio. 48 samples. Type: Expression profiling by high throughput sequencing.
Per- and polyfluoroalkyl substances (PFAS) suppress macrophage alternative activation to disrupt hepatic lipid metabolism [RNA-seq II]
GEO Series GSE284229. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
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