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34 results for “platelet count”
Hemoglobin, Neutrophil to Lymphocyte Ratio and Platelet Count Improve Prognosis Prediction in Nasopharyngeal Carcinoma
ClinicalTrials.gov study NCT02211677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Anagrelide Controlled Release (GALE-401) in Patients With High Platelet Counts Due to Bone Marrow Disorders
ClinicalTrials.gov study NCT02125318. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Explore the Relationship Between Platelet Count and Bleeding Score in ITP
ClinicalTrials.gov study NCT06273956. IPD Sharing: NO. Countries: 1. Publications: 0.
To Assess the Efficacy of Carica Papaya Leaf Extract in Improving Platelet Counts Among Pediatric Patients With Dengue-associated Thrombocytopenia
ClinicalTrials.gov study NCT07172100. IPD Sharing: YES. Countries: 1. Publications: 0.
Platelet Count（PC）/Spleen Diameter(SD) Ratio to Predict the Variceal Haemorrhage in HBV Cirrhotic Patients in China
ClinicalTrials.gov study NCT02546414. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.
ClinicalTrials.gov study NCT07200817. IPD Sharing: YES. Countries: 1. Publications: 0.
Correlation of Platelets Count With Endoscopic Findings in a Cohort of Egyptian Patients With Liver Cirrhosis
ClinicalTrials.gov study NCT02621372. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of the Effect in Platelet Count of Atorvastatin and N-acetyl Cysteine
ClinicalTrials.gov study NCT05551624. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Platelet Count, Platelet, Mean Platelet Volume and Platelet Distribution Width in COVID-19
ClinicalTrials.gov study NCT04378829. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gemcitabine and Oxaliplatin for Hepatocellular Carcinoma With Platelet Counts Greater Than 100,000 Per Microliter
ClinicalTrials.gov study NCT00250822. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Hemodialysis Membranes on Platelet Count
ClinicalTrials.gov study NCT01356576. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immune cells surveil aberrantly sialylated O-glycans on megakaryocytes to regulate platelet count
GEO Series GSE179067. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Platelet Contribution to Clot Strength in Thromboelastometry: Count, Function, or Both?
<p>Dataset from the article Ranucci M, Di Dedda U, Baryshnikova E. Platelet Contribution to Clot Strength in Thromboelastometry: Count, Function, or Both? Platelets. 2020;31(1):88-93. doi: 10.1080/09537104.2019.1581920. Epub 2019 Mar 4. PMID: 30831043.</p> <p>Abstract</p> <p>In thromboelastometry (ROTEM<sup>TM</sup>) the difference in amplitude between the EXTEM and the FIBTEM is considered an index of platelet contribution to clot strength (PCS<sub>amp</sub>). The difference in elasticity (PCS<sub>el</sub>) is rarely used. We investigated the ability of PCS<sub>amp</sub> and PCS<sub>el</sub> in reflecting platelet count and function in 103 patients undergoing cardiac surgery, simultaneously measuring ROTEM and platelet function tests (multiple electrode aggregometry ADPtest and TRAPtest, Multiplate<sup>TM</sup>). PCS<sub>amp</sub> and PCS<sub>el</sub> were tested for association with platelet count and function. The PCS<sub>amp</sub> showed a low (R coefficient 0.32-0.39) association with platelet count and function (ADPtest), whereas the PCS<sub>el</sub> showed higher values of association (R coefficient 0.55-0.71) with the same variables. No association was found between PCS and TRAPtest. In a multivariable model, both the platelet count (R coefficient 0.60, P = 0.001) and the ADPtest (R coefficient 0.36, P = 0.001) were independently associated with the PCS<sub>el</sub>. The discrimination properties of the PCS<sub>el</sub> for the prediction of a low platelet count/function were very good (c-statistics 0.837). In clinical practice, the difference in elasticity between EXTEM and FIBTEM should replace the difference in amplitude.</p>
High immature platelet fraction with reduced platelet count on hospital admission. Can be useful for Covid-19 diagnosis?
<p>This record contains raw data related to the article:</p> <p> </p> <p><strong>High immature platelet fraction with reduced platelet count on hospital admission. Can be useful for Covid-19 diagnosis?</strong></p> <p> </p> <p><strong>Short running title</strong>: Platelet parameters and Covid-19</p> <p> </p> <p>Giovanni Introcaso, Alice Bonomi, Laura Salvini, Tiziana D’Errico, Annalisa Cattaneo, Emilio Assanelli, Silvia Stella Barbieri, Maria Luisa Biondi</p> <p> </p> <p>GI, TD, AC, MLB, Unit of Laboratory Medicine – Centro Cardiologico IRCCS Monzino – Milan Italy</p> <p>AB, Unit of Biostatistics– Centro Cardiologico IRCCS Monzino – Milan Italy</p> <p>LS, EA, Emergency Department– Centro Cardiologico IRCCS Monzino – Milan Italy</p> <p>SSB, Unit of Brain-Heart Axis - Centro Cardiologico IRCCS Monzino – Milan Italy</p> <p> </p> <p> </p> <p>Corresponding author: Giovanni Introcaso, Unit of Laboratory Medicine, Centro Cardiologico IRCCS Monzino – Milan Italy</p> <p>Via Parea , 20138 Milano, phone: 0039/0258002595</p> <p>e-mail: giovanni.introcaso@ccfm.it</p> <p> </p> <p> </p> <p><strong>Keywords: </strong>Platelet parameters, H-IPF, Covid-19, Hematological biomarkers, Emergency Department</p> <p> </p> <p> </p> <p> </p> <p> </p> <p><strong>ABSTRACT</strong></p> <p> </p> <p><strong>Introduction</strong>: Health professions are heavily engaged facing the current threat of Sars Cov-2 (Covid-19). Although there are many diagnostic tools, an accurate and rapid laboratory procedure for diagnosing Covid-19 is recommended. We focused on platelet parameters as additional biomarkers for clinical diagnosis in patients presenting to the emergency department (ED).</p> <p><strong>Materials and</strong> <strong>Methods</strong>: 561 patients from February to April, 2020 have been recruited. Patients were divided into three groups: (N=50) Covid-19 positive and (N= 21) Covid-19 negative with molecular testing, (N=490) as reference population without molecular testing. A Multiplex rRT-PCR from samples collected by nasopharyngeal swabs was performed and the hematological data collected.</p> <p><strong>Results</strong>: We detected a mild anemia in Covid-19 group and lymphopenia against reference population: hemoglobin (g/dL) 13.0 (11.5-14.8) vs 13.9 (12.8-15.0) (p=0.0135); lymphocytes (10<sup>9</sup>/L) 1.24 (0.94-1.73) vs 1.99 (1.49-2.64) (p<0.0001). In addition, abnormal platelet parameters as follows (Covid group versus reference population): PLT (x10<sup>9</sup>/L) 209(160-258) vs 236(193-279) (p=0.0239). IPF (%) 4.05 (2.5-5.9) vs 3.4 (2.2-4.9) (p=0.0576); H-IPF (%) 1.25 (0.8-2.2) vs 0.95 (0.6-1.5) (p=0.0171) were identified. In particular, Covid positive group had a high H-IPF/IPF Ratio compared to reference population [0.32 (0.29-0.36) vs 0.29 (0.26-0.32), respectively, (p=0.0003)]. Finally, a PLT difference of nearly 50x10<sup>9</sup>/L between pre/post Covid-19 sampling for each patient was found (N=42) (p=0.0194). <strong>Conclusions</strong>: Covid-19 group results highlighted higher IPF and H-IPF values, with increased H-IPF/IPF Ratio, associated to PLT count reduction. These findings shall be adopted for a timely diagnosis of patients upon hospital admission.</p>
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