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44 results for “polycyclic aromatic hydrocarbons”
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China
ClinicalTrials.gov study NCT00342472. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Early mechanistic events induced by low molecular weight polycyclic aromatic hydrocarbons in mouse lung epithelial cells: a role for eicosanoid signaling
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Air–water exchange and gas-particle partitioning of polycyclic aromatic hydrocarbons (PAHs) in coral reef areas of the South China Sea
<p>Supporting information</p>
Data from: Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor.
Extracellular vesicles (EVs) are membrane enclosed nanostructures released by cells into the extracellular environment. As major actors of physiological intercellular communication, they have been shown to be pathogenic mediators of several liver diseases. EVs also appear to be potential actors of drug-induced liver injury, but nothing is known concerning environmental pollutants. We aimed to study the impact of polycyclic aromatic hydrocarbons (PAHs), major contaminants, on hepatocyte-derived EV production, with a special focus on hepatocyte death. Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Treatment of primary rat and WIF-B9 hepatocytes by all three PAHs increased the release of EVs, mainly comprised of exosomes, in parallel with modifying exosome protein marker expression and inducing apoptosis. Moreover, PAH treatment of rodents for three months also led to increased EV levels in plasma. The EV release involved CYP metabolism and the activation of the transcription factor, the AhR, for BP and DBA and another transcription factor, the constitutive androstane receptor (CAR), for PYR. Furthermore, all PAHs increased cholesterol levels in EVs but only BP and DBA were able to reduce the cholesterol content of total cell membranes. All cholesterol changes very likely participated in the increase in EV release and cell death. Finally, we studied changes in cell membrane fluidity caused by BP and DBA due to cholesterol depletion. Our data showed increased cell membrane fluidity, which contributed to hepatocyte EV release and cell death.
Data from: Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor.
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Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse
GEO Series GSE39455. Mus musculus. 25 samples. Type: Expression profiling by array.
Transcriptomic response of the polycyclic aromatic hydrocarbon-degrading Sphingomonas sp. LH128 upon long-term starvation stress
GEO Series GSE41814. Sphingomonas sp. LH128. 6 samples. Type: Expression profiling by array.
Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
GEO Series GSE44130. Danio rerio. 32 samples. Type: Expression profiling by array.
Sub-chronic pulmonary transcriptional response to a mixture of 8 polycyclic aromatic hydrocarbons in adult male MutaTMMouse.
GEO Series GSE87689. Mus musculus. 19 samples. Type: Expression profiling by array.
Transcriptomic response of the polycyclic aromatic hydrocarbon-degrading Sphingomonas sp. LH128 upon short-term starvation stress
GEO Series GSE44310. Sphingomonas sp. LH128. 6 samples. Type: Expression profiling by array.
Sub-chronic pulmonary transcriptional response to mixtures of polycyclic aromatic hydrocarbons (PAHs)
GEO Series GSE87691. Mus musculus. 57 samples. Type: Expression profiling by array.
Assessing susceptibility for polycyclic aromatic hydrocarbon toxicity in an in vitro 3D respiratory model for asthma
GEO Series GSE239797. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Detection of interstellar 1-cyanopyrene: a four-ring polycyclic aromatic hydrocarbon
<div>This is the dataset for the article:</div> <div>Detection of interstellar 1-cyanopyrene: a four-ring polycyclic aromatic hydrocarbon</div> <div> </div> <div>Authors:</div> <div>GOTHAM Collaboration</div> <div> </div> <div>DOI:</div> <div>DOI: 10.1126/science.adq6391</div> <div> </div> <div>Journal:</div> <div>Science</div> <div> </div> <div>Corresponding authors:</div> <div>Gabi Wenzel, Ilsa R. Cooke, Brett A. McGuire</div> <div> </div> <div>To cite this:</div> <div>Gabi Wenzel et al., Detection of interstellar 1-cyanopyrene: A four-ring polycyclic aromatic hydrocarbon. Science 386, 810-813 (2024). DOI:10.1126/science.adq6391</div> <div> </div> <div>#--------------------------------------------------------------------------------------</div> <div> </div> <div>Folders:</div> <div> - DATA_1-cyanopyrene_spectroscopy contains all SPCAT/SPFIT files for 1-cyanopyrene</div> <div>(Figs. 2, 3, S3, S5, S7) including the partition function in the .qpart file</div> <div> - DATA_Fig2 contains the unsmoothed GOTHAM data as presented in Fig. 2</div> <div> - DATA_SNRLinesinStack contains the unsmoothed GOTHAM data centered around each of the</div> <div>150 brightest SNR lines that are contained in the stack (Figs. 3, S5, S6, S7)</div> <div> </div> <div>#--------------------------------------------------------------------------------------</div> <div> </div>
Air-sea gas exchange and its potential influence on regional fate of polycyclic aromatic hydrocarbons in the East China Marginal Sea
<p>This dataset includes the meteorology and hydrology data in the East China Sea (ECS) and Yellow Sea (YS), the information of air and seawater samples, the gaseous and dissolved concentration of polycyclic aromatic hydrocarbons (PAHs) in the ECS and YS, the air-sea gas exchange fluxes of PAHs in the ECS and YS.</p>
IMPACT OF POLYCYCLIC AROMATIC HYDROCARBONS (PAH) ON IN VITRO FERTILIZATION
ClinicalTrials.gov study NCT03914859. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures
GEO Series GSE156147. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Coupling genome-wide transcriptomics and developmental toxicity profiles in zebrafish to characterize polycyclic aromatic hydrocarbon (PAH) hazard
GEO Series GSE156656. Danio rerio. 72 samples. Type: Expression profiling by high throughput sequencing.
Effects of polycyclic aromatic hydrocarbons on osteoclasts and osteoblasts in the scales of zebrafish
GEO Series GSE161253. Danio rerio. 3 samples. Type: Expression profiling by array.
Binary polycyclic aromatic hydrocarbon exposure alters the transcriptome inducing inflammation and inhibiting cell communication through p38 MAPK in lung cells
GEO Series GSE84649. Mus musculus. 18 samples. Type: Expression profiling by array.
Whole Genome Expression in Peripheral-Blood Samples of Workers Professionally Exposed to Polycyclic Aromatic Hydrocarbons
GEO Series GSE30504. Homo sapiens. 32 samples. Type: Expression profiling by array.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.