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69 results for “primary growth”
A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer
ClinicalTrials.gov study NCT01358877. IPD Sharing: YES. Countries: 42. Publications: 9.
Herceptin (Trastuzumab) in Treating Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Primary Breast Cancer
ClinicalTrials.gov study NCT00045032. IPD Sharing: Not stated. Countries: 33. Publications: 18.
Linking variation in planktonic primary production to coral reef fish growth and condition
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Data from: Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet
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Data: Large old trees increase growth under shifting climatic constraints: Aligning tree longevity and individual growth dynamics in primary mountain spruce forests
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Data from: A novel phenotype combining primary ovarian insufficiency growth retardation and pilomatricomas with MCM8 mutation
<p><b>Context</b>: Primary Ovarian insufficiency (POI) affects 1% of women under 40 years and leads most often to definitive infertility with adverse health outcomes. Very recently, genes involved in DNA repair have been shown to cause POI. </p> <p><b>Objective</b>: To identify the cause of a familial POI in a consanguineous Turkish family.</p> <p><b>Design:</b> Exome sequencing was performed in the proposita and her mother. Chromosomal breaks were studied in lymphoblastoid cell lines treated with Mitomycin (MMC).</p> <p><b>Setting and patients:</b> The proposita presented intra-uterine and post-natal growth retardation, multiple pilomatricomas in childhood and primary amenorrhea. She was treated with growth hormone (GH) from 14 to 18 years.</p> <p><b>Results:</b> We identified a novel nonsense mutation in exon 9 of the minichromosome maintenance complex component 8 gene (<i>MCM8)</i> NM_001281522.1: c.925C>T/p.R309* yielding a truncated protein devoid of the 531 C-terminal residues. </p> <p>The mutation was homozygous in the daughter and heterozygous in the mother. MMC induced DNA breaks and aberrant metaphases in the patient's lymphoblastoid cells. The mother's cells had intermediate but significantly higher chromosomal breaks compared to a control.</p> <p><b>Conclusion</b>: We describe a novel phenotype of syndromic POI related to a novel truncating <i>MCM8</i> mutation. We show for the first time that spontaneous tumors (pilomatricomas) are associated with <i>MCM8</i> genetic defect making the screening of this gene necessary before starting GH therapy in POI with short stature, especially in a familial or consanguineous context. Appropriate familial monitoring in the long term is necessary and fertility preservation should be considered in heterozygous siblings to avoid rapid follicular atresia.</p>
A Study of Bevacizumab (Avastin) in Combination With Neoadjuvant Treatment Regimens in Participants With Primary Human Epidermal Growth Factor Receptor 2 (HER2) Negative Breast Cancer
ClinicalTrials.gov study NCT00773695. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).
ClinicalTrials.gov study NCT00903110. IPD Sharing: Not stated. Countries: 11. Publications: 4.
Intra-articular Injection of Allogenic Lyophilized Growth Factors in Primary Knee Osteoarthritis
ClinicalTrials.gov study NCT04331327. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: A novel phenotype combining primary ovarian insufficiency growth retardation and pilomatricomas with MCM8 mutation
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Effect of Zinc Supplementation on Appetite and Growth in Primary Malnourished Children
ClinicalTrials.gov study NCT03098810. IPD Sharing: NO. Countries: 0. Publications: 1.
Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency
ClinicalTrials.gov study NCT00125164. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Children and Adolescents With Growth Failure Associated With Primary IGF-1 Deficiency
ClinicalTrials.gov study NCT00330668. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Prospective Non-Interventional Study Protocol With Primary Data Collection - Assessment Of The Long Term Treatment Outcomes Of Genotropin Treatment In Growth Hormone Deficiency (GHD) Patients
ClinicalTrials.gov study NCT01947894. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Evaluating the influences of temperature, primary production, and evolutionary history on bivalve growth rates
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Ribosome incorporation transdifferentiates chick primary cells and induces their proliferation by secreting growth factors
GEO Series GSE289409. Gallus gallus. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA-seq insights into primary root apical meristem exhaustion and determinate root growth in Pachycereus pringlei (Cactaceae)
GEO Series GSE104832. Pachycereus pringlei. 6 samples. Type: Expression profiling by high throughput sequencing.
ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth
GEO Series GSE42412. Homo sapiens. 4 samples. Type: Expression profiling by array.
p53 deficiency linked to BTG2 loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in PDX models of triple negative breast cancer
GEO Series GSE76433. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Friend or Foe? Primary Tumor represses distant metastases' growth via exosomal miRNA-1
GEO Series GSE213969. Canis lupus familiaris. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.