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114
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ShareScore release 0.9.0
Dataset results
114 results for “programmed cell death”
Study of Pembrolizumab (MK-3475) Versus Platinum-Based Chemotherapy for Participants With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Advanced or Metastatic Non-Small Cell Lung Cancer (MK-3475-042
ClinicalTrials.gov study NCT03850444. IPD Sharing: YES. Countries: 0. Publications: 1.
Regorafenib Plus Programmed Cell Death-1 (PD-1) Inhibitors in Patients With Advanced Colorectal Cancer
ClinicalTrials.gov study NCT04771715. IPD Sharing: NO. Countries: 1. Publications: 1.
Anti-programmed Cell Death-1 Ligand 1 (aPDL-1) Antibody Atezolizumab, Bevacizumab and Acetylsalicylic Acid in Recurrent Platinum Resistant Ovarian Cancer
ClinicalTrials.gov study NCT02659384. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
ClinicalTrials.gov study NCT02715284. IPD Sharing: YES. Countries: 10. Publications: 11.
Data from: High specificity in circulating tumor cell identification is required for accurate evaluation of programmed death-ligand 1
Background: Expression of programmed-death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) is typically evaluated through invasive biopsies; however, recent advances in the identification of circulating tumor cells (CTCs) may be a less invasive method to assay tumor cells for these purposes. These liquid biopsies rely on accurate identification of CTCs from the diverse populations in the blood, where some tumor cells share characteristics with normal blood cells. While many blood cells can be excluded by their high expression of CD45, neutrophils and other immature myeloid subsets have low to absent expression of CD45 and also express PD-L1. Furthermore, cytokeratin is typically used to identify CTCs, but neutrophils may stain non-specifically for intracellular antibodies, including cytokeratin, thus preventing accurate evaluation of PD-L1 expression on tumor cells. This holds even greater significance when evaluating PD-L1 in epithelial cell adhesion molecule (EpCAM) positive and EpCAM negative CTCs (as in epithelial-mesenchymal transition (EMT)). Methods: To evaluate the impact of CTC misidentification on PD-L1 evaluation, we utilized CD11b to identify myeloid cells. CTCs were isolated from patients with metastatic NSCLC using EpCAM, MUC1 or Vimentin capture antibodies and exclusion-based sample preparation (ESP) technology. Results: Large populations of CD11b+CD45lo cells were identified in buffy coats and stained non-specifically for intracellular antibodies including cytokeratin. The amount of CD11b+ cells misidentified as CTCs varied among patients; accounting for 33–100% of traditionally identified CTCs. Cells captured with vimentin had a higher frequency of CD11b+ cells at 41%, compared to 20% and 18% with MUC1 or EpCAM, respectively. Cells misidentified as CTCs ultimately skewed PD-L1 expression to varying degrees across patient samples. Conclusions: Interfering myeloid populations can be differentiated from true CTCs with additional staining criteria, thus improving the specificity of CTC identification and the accuracy of biomarker evaluation.
Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 (PD-L1) Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
ClinicalTrials.gov study NCT04128696. IPD Sharing: YES. Countries: 26. Publications: 0.
Vopratelimab (JTX-2011) Alone and in Combination With Anti-Programmed Cell Death Protein 1 (PD-1) or Anti-Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) in Subjects With Advanced and/or Refractory Solid Tu
ClinicalTrials.gov study NCT04319224. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastat
ClinicalTrials.gov study NCT05523323. IPD Sharing: YES. Countries: 1. Publications: 0.
Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-
ClinicalTrials.gov study NCT04738487. IPD Sharing: YES. Countries: 23. Publications: 0.
Camrelizumab Combined With Apatinib Mesylate or Camrelizumab Alone for First-line Treatment in Subjects With Programmed Death Ligand 1 (PD-L1) Positive Relapsed or Advanced Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT04203485. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Data from: High specificity in circulating tumor cell identification is required for accurate evaluation of programmed death-ligand 1
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Programmed death 1 receptor blockade and immune-related gene expression profiling in non-small cell lung carcinoma, head and neck squamous cell carcinoma and melanoma
GEO Series GSE93157. Homo sapiens. 65 samples. Type: Expression profiling by array.
Plant U-Box 4 regulates chloroplast stress signaling and programmed cell death via Salicylic acid modulation
GEO Series GSE268259. Arabidopsis thaliana. 18 samples. Type: Expression profiling by high throughput sequencing.
A Multi-Omics Landscape of Programmed Cell Death in Acetaminophen-Induced Acute Kidney Injury
GEO Series GSE295115. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
PNPLA3-I148M genetic variant rewires lipid metabolism to drive programmed cell death in human hepatocytes
GEO Series GSE309786. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
A decision-point between programmed cell death and transdifferentiation in pancreatic cancer
GEO Series GSE275488. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Bacterial lipopolysaccharides induce defense responses associated with Programmed cell death in rice cell
GEO Series GSE5906. Oryza sativa; Oryza sativa Japonica Group. 4 samples. Type: Expression profiling by array.
Control of a programmed cell death pathway in Pseudomonas aeruginosa by a ppGpp-responsive antiterminator [RNAtag-seq]
GEO Series GSE152480. Pseudomonas aeruginosa PAO1. 9 samples. Type: Expression profiling by high throughput sequencing.
Small RNA and mRNA profiling during intersegmental muscle development and programmed cell death in Manduca sexta
GEO Series GSE80830. Manduca sexta. 30 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways [HEK293T]
GEO Series GSE70167. Homo sapiens. 11 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.