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213 results for “proteasome”
Nelfinavir as Bortezomib-sensitizing Drug in Patients With Proteasome Inhibitor-nonresponsive Myeloma
ClinicalTrials.gov study NCT02188537. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of DARZALEX (Daratumumab) In Indian Participants With Relapsed and Refractory Multiple Myeloma, Whose Prior Therapy Included a Proteasome Inhibitor and an Immunomodulatory Agent
ClinicalTrials.gov study NCT03768960. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Proteasome Inhibition in Acute Promyelocytic Leukemia
ClinicalTrials.gov study NCT01950611. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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Single molecule images for: An empirical energy landscape reveals mechanism of proteasome in polypeptide translocation
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Characterization of platinum(II) complexes exhibiting inhibitory activity against 20S Proteasome
<p><span>Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracene and heterocycle exhibited proteasome inhibitory activity. In the present study, the structure-activity relationships and characterization of these complexes were determined for elucidation of role of aromatic ligands. Lineweaver-Burk analysis revealed that the chemical structure of heterocyles affects binding mode of platinum complexes. Platinum complexes with anthracene and pyridine showed competitive inhibition although platinum complexes with antharcene and phenantholine showed non-competitive inhibition. The structure-activity relationships demonstrated that anthracene moiety play a crucial role for proteasome inhibitory activity. The platinum complexes with naphthalene or benzene exhibited lower inhibitory activities than the platinum complex with anthracene. The reactivity with N-acetyl cysteine varied according to the chemical structure of complexes. </span></p>
Data from: Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes
Proteasomal protein degradation is a key determinant of protein half-life and hence of cellular processes ranging from basic metabolism to a host of immunological processes. Despite its importance the mechanisms regulating proteasome activity are only incompletely understood. Here we use an iterative and tightly integrated experimental and modelling approach to develop, explore and validate mechanistic models of proteasomal peptide-hydrolysis dynamics. The 20S proteasome is a dynamic enzyme and its activity varies over time because of interactions between substrates and products and the proteolytic and regulatory sites; the locations of these sites and the interactions between them are predicted by the model, and experimentally supported. The analysis suggests that the rate-limiting step of hydrolysis is the transport of the substrates into the proteasome. The transport efficiency varies between human standard- and immuno-proteasomes thereby impinging upon total degradation rate and substrate cleavage-site usage.
Data from: A large fraction of HLA class I ligands are proteasome-generated spliced peptides
The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class I molecules that elicit CD8+ T cell responses. Reports of proteasome-generated spliced epitopes exist, but they have been regarded as rare events. Here, however, we show that the proteasome-generated spliced peptide pool accounts for one-third of the entire HLA class I immunopeptidome in terms of diversity and one-fourth in terms of abundance. This pool also represents a unique set of antigens, possessing particular and distinguishing features. We validated this observation using a range of complementary experimental and bioinformatics approaches, as well as multiple cell types. The widespread appearance and abundance of proteasome-catalyzed peptide splicing events has implications for immunobiology and autoimmunity theories and may provide a previously untapped source of epitopes for use in vaccines and cancer immunotherapy.
Impact of Proteasome Inhibition on Anti-Donor HLA Antibody Production After Kidney Transplantation
ClinicalTrials.gov study NCT01349595. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety Study of the Proteasome Inhibitor PR-171 (Carfilzomib for Injection) in Patients With Hematological Malignancies
ClinicalTrials.gov study NCT00150462. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes
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Data from: A large fraction of HLA class I ligands are proteasome-generated spliced peptides
Open the record for dataset details and reuse information.
Characterization of platinum(II) complexes exhibiting inhibitory activity against 20S Proteasome
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Proteasome subunit RPT2a promotes PTGS through repressing RNA quality control in Arabidopsis
GEO Series GSE131009. Arabidopsis thaliana. 4 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Effect of CRY2 stabilizer and proteasome inhibitor on the activity of cis-regulatory elements in MDA-MB-231 cells [STARR-seq]
GEO Series GSE266012. Homo sapiens. 4 samples. Type: Other.
Proteasome dysfunction in T cells causes immunodeficiency via cell cycle disruption and apoptosis
GEO Series GSE291117. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α
GEO Series GSE283363. Megalobrama amblycephala. 10 samples. Type: Expression profiling by high throughput sequencing.
Cellular response to proteasome inhibition by Bortezomib
GEO Series GSE71145. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Secondary proteasome inhibitor carfilzomib resistant myeloma cell lines
GEO Series GSE62237. Homo sapiens. 8 samples. Type: Expression profiling by array.
Analysis of transcriptional changes associated to proteasome inhibition in HCT-116 human colorectal cancer cells
GEO Series GSE165325. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.