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opencc-zeroDec 2022View details →

Whole blood RNA-seq demonstrates an increased host immune response in individuals with cystic fibrosis who develop nontuberculous mycobacterial pulmonary disease

Background Individuals with cystic fibrosis have an elevated lifetime risk of colonization, infection, and disease caused by nontuberculous mycobacteria. A prior study involving non-cystic fibrosis individuals reported a gene expression signature associated with susceptibility to nontuberculous mycobacteria pulmonary disease (NTM-PD). In this study, we determined whether people living with cystic fibrosis who progress to NTM-PD have a gene expression pattern similar to the one seen in the non-cystic fibrosis population. Methods We evaluated whole blood transcriptomics using bulk RNA-seq in a cohort of cystic fibrosis patients with samples collected closest in timing to the first isolation of nontuberculous mycobacteria. The study population included patients who did (n = 12) and did not (n = 30) develop NTM-PD following the first mycobacterial growth. Progression to NTM-PD was defined by a consensus of two expert clinicians based on reviewing clinical, microbiological, and radiological information. Differential gene expression was determined by DESeq2. Results No differences in demographics or composition of white blood cell populations between groups were identified at baseline. Out of 213 genes associated with NTM-PD in the non-CF population, only two were significantly different in our cystic fibrosis NTM-PD cohort. Gene set enrichment analysis of the differential expression results showed that CF individuals who developed NTM-PD had higher expression levels of genes involved in the interferon (α and γ), tumor necrosis factor, and IL6-STAT3-JAK pathways. Conclusion In contrast to the non-cystic fibrosis population, the gene expression signature of patients with cystic fibrosis who develop NTM-PD is characterized by increased innate immune responses.

zenodo40/100

Dataset for: Laser absorption spectroscopy measurements of different pulmonary oxygen gas concentrations in transmittance and remittance geometry – phantom study

Significance GASMAS technique has the potential for continuous, clinical monitoring of pre-term infant lung function, removing the need to X-ray diagnosis and reliance on indirect and relatively slow measurement of blood oxygenation. Aim To determine optimal source-detector configuration for reliable path lengths calculation and to estimate the oxygen gas concentration inside the lung cavities filled with humidified gas with four different oxygen gas concentrations ranging between 21% and 100%. Approach Anthropomorphic optical phantoms of neonatal thorax with two different geometries were used to acquire Gas in Scattering Media Absorption Spectroscopy (GASMAS) signals, for 30 source-detector configurations in transmittance and remittance geometry of phantoms in two sizes. Results The results show that an internal light administration is more likely to provide a high GASMAS signal-to-noise ratio (SNR). In general, better SNRs were obtained with the smaller set of phantoms. The values of path length and O2 concentrations calculated with signals from the phantoms with optical properties at 820 nm, exhibit higher variations than signals from the phantoms with optical properties at 764 nm. Conclusion The study shows that by moving the source and detector over the thorax, most of the lung volumes can potentially be assessed using GASMAS technique.

opencc-by-4.0Aug 2023View details →

E-Cigarette Effects on Markers of Cardiovascular and Pulmonary Disease

ClinicalTrials.gov study NCT03863509. IPD Sharing: YES. Countries: 1. Publications: 1.

Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT: (the RELIANT Trial)

ClinicalTrials.gov study NCT05705544. IPD Sharing: YES. Countries: 1. Publications: 12.

An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study

ClinicalTrials.gov study NCT04108130. IPD Sharing: YES. Countries: 1. Publications: 11.

Dose-finding Study to Assess the Efficacy, Safety and Tolerability of Tobramycin Inhalation Powder in Patients With Non-Cystic Fibrosis Bronchiectasis and Pulmonary P. Aeruginosa Infection

ClinicalTrials.gov study NCT02712983. IPD Sharing: YES. Countries: 6. Publications: 2.

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, with Pretomanid and Linezolid in Adults with Drug-sensitive Pulmonary Tuberculosis

ClinicalTrials.gov study NCT06058299. IPD Sharing: YES. Countries: 5. Publications: 3.

Effect of Respiratory Exerciser on Pulmonary Functions of COVID-19 Patients

ClinicalTrials.gov study NCT04826731. IPD Sharing: YES. Countries: 1. Publications: 4.

Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

ClinicalTrials.gov study NCT03546907. IPD Sharing: YES. Countries: 10. Publications: 1.

publicAug 2024View details →

Enzyme-like nanoparticle engineered-mesenchymal stem cell secreting HGF promotes visualized therapy for idiopathic pulmonary fibrosis in vivo

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publicMar 2024View details →

Data from: Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner

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publicApr 2023View details →

Whole blood RNA-seq demonstrates an increased host immune response in individuals with cystic fibrosis who develop nontuberculous mycobacterial pulmonary disease

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opencc-by-4.0May 2020View details →

Not only pulmonary rehabilitation for critically ill patients with COVID-19

Background Prolonged immobility in COVID-19 patients in mechanical ventilation combined with the infection-mediated harmful immune response can be responsible of peripheral nervous system complications, such as Intensive Care Unit Acquired Weakness (ICU-AW). We report preliminary findings of our monocentric prospective study. Method Prospective observational study of PCR-confirmed COVID-19 patients in mechanical ventilation in the Intensive Care Unit of Azienda Ospedaliero Universitaria Careggi (Firenze). We evaluated: 1. muscle power grading on motor response to nociceptive stimuli by means of MRC; 2. nerve conduction velocities, compound muscle action potentials (CMAP) and sensory nerve action potentials (SNAP) of six motor and four sensitive nerves in bilateral upper and lower limbs; 3. spontaneous muscle activity in bilateral tibialis anterior and biceps by needle. The presence of combined critical illness polyneuropathy and myopathy (CIPNM) was defined by very low amplitude of CMAP and/or SNAP on neurophysiological evaluation with normal or mildly reduced nerve conduction velocities, combined with myopathic features on needle electromyography. Data about pre-existing comorbidities such as diabetes and hypertension were also collected. Findings Between March 23 March 2020 to 10 April 2020, we performed ENG studies in 9 patients. Based on clinical examination ICU-AW (MRC score <48/60) was present in all 9 patients. Four of them had diagnosis of CIPNM at neurophysiological evaluation, and 3 of the remaining 5 patients presented neurophysiological findings consistent with common peroneal nerve compression Interpretation The present findings suggest that in critically ill patients affected by COVID-19 functional motor deficits are highly prevalent and should be searched for. ICU-AW have been found to negatively affect weaning from mechanical ventilation long-term outcome and increase in-hospital mortality of critical patients. Early recognition of these complications could help clinicians to plan an appropriate neuromotor rehabilitation (e.g. by early passive limbs mobilization and posture changes) for improving respiratory function and clinical outcome. Funding None

opencc-by-4.0Dec 2020View details →

DNA methylation following long-term pulmonary multi-walled carbon nanotubes exposure in mice

Whole Genome Bisulphite Sequencing (WGBS) experiment to assess DNA methylation patterns in mice lungs 56 days after exposure to Multi-Walled Carbon NanoTubes (MWCNTs). The doses of MWCNTs used in this experiment were 0, 40 or 80 μg/mouse. In this record, we provide WGBS coverage files along with bedgraph files.

dryad36/100

Data from: Association between total dose of ritodrine hydrochloride and pulmonary edema in twin pregnancy: a retrospective cohort study in Japan

Objective Pulmonary edema is recognized as a severe side effect of ritodrine hydrochloride. Recently, the number of twin pregnancies has been increasing. Few studies have reported the association between total dose of ritodrine hydrochloride prior to delivery and pulmonary edema in twin pregnancy. We aimed to examine this association and determine the optimal cutoff threshold of total ritodrine hydrochloride dose to predict the incidence of pulmonary edema in twin pregnancy, based on obstetric records. Design Retrospective cohort study. Setting Yamanashi Prefectural Central Hospital, Japan Participants Two hundred twenty-six women with twin pregnancy who delivered at Yamanashi Prefectural Central Hospital between September 2009 and November 2016 Methods The obstetric records of the participants were analyzed. We defined one unit of ritodrine hydrochloride as 72 mg per 24 h continuous transfusion at 50 µg/min to calculate the dose of ritodrine used for tocolysis. Outcome measures Multivariable logistic regression analysis was performed to examine the association between total dose of ritodrine hydrochloride used for threatened preterm labor and pulmonary edema, while controlling for potential confounding factors. Then, a receiver-operating characteristic curve was used to determine the optimal cutoff of total ritodrine dose to predict pulmonary edema incidence. Results Mean maternal age was 32 (range, 18-46) years; 143 participants were nulliparous (63.3%), 109 had (48.2%) term deliveries, and 194 (85.8%) had cesarean deliveries. The overall incidence of pulmonary edema was 13.7% (31/226). Multivariable analysis showed that the total dose of ritodrine was significantly associated with pulmonary edema (adjusted odds ratio 1.02; 95% confidence interval, 1.004-1.03). The best cut-off point to predict the incidence of pulmonary edema was 26 units (1872 mg) (sensitivity, 61.3%; specificity, 87.8%). Conclusion Our results suggest that consideration of the total dose of ritodrine hydrochloride is helpful in the management of patients with threatened preterm labor in twin pregnancy.

opencc-zeroDec 2016View details →

opencc-by-sa-4.0Oct 2015View details →

Automatic Synthesis of Anthropomorphic Pulmonary CT Phantoms - DICOM Database

This dataset contains DICOM versions of the 24 anthropomorphic pulmonary CT phantoms accompanying the manuscript "Automatic Synthesis of Anthropomorphic Pulmonary CT Phantoms" submitted to PLoS ONE. NRRD versions can be found in http://dx.doi.org/10.5281/zenodo.20766 (doi:10.5281/zenodo.20766).

opencc-by-sa-4.0Jul 2015View details →

Automatic Synthesis of Anthropomorphic Pulmonary CT Phantoms - NRRD Database

This dataset contains the 24 anthropomorphic pulmonary CT phantoms accompanying the manuscript "Automatic Synthesis of Anthropomorphic Pulmonary CT Phantoms" submitted to PLoS ONE. DICOM versions can be found at http://dx.doi.org/10.5281/zenodo.32740  (doi:10.5281/zenodo.32740)