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1,189 results for “randomized clinical trial”
The influence of the statistical significance of results and spin on readers' interpretation of the results in an abstract for a hypothetical clinical trial: A randomized trial
<p><strong>Objectives</strong>: To assess the impact on readers' interpretation of the results reported in an abstract for a hypothetical clinical trial with 1) a statistically significant result, 2) spin, 3) both a statistically significant result and spin compared to 4) no spin and no statistically significant result.</p> <p><strong>Participants</strong>: Health students and professionals from universities and health institutions in France and the UK.</p> <p><strong>Interventions</strong>: Participants completed an online questionnaire using Likert scales and free text, after reading one of the four versions of an abstract about a hypothetical randomized trial evaluating "Naranex" and "Bulofil" (two hypothetical drugs) for chronic low back pain. The abstracts differed in a) reported result of "mean difference of 1.31 points (95%CI 0.08 to 2.54; p= 0.04)" or "mean difference of 1.31 points (95%CI -0.08 to 2.70; p= 0.06)" and b) presence or absence of spin. The effect size for the trial's primary outcome (pain disability score) was the same in each abstract; slightly in favour of Naranex.</p> <p><strong>Primary outcome</strong>: The reader's interpretation of the trial's results, based on their answer (1: disagree, 4: neutral, 7: agree) to the following statement: "About the main findings of the study, what is your opinion about the following statement: 'Naranex is better than Bulofil'?"</p> <p><strong>Results</strong>: 297 of the 404 people randomized to receive one of the four abstracts completed the study. Respondents were more likely to favour Narenex when the abstract reported a statistically significant result without spin; a statistically significant result with spin, a non-statistically significant result with spin, compared to when it reported a non-statistically significant result without spin.</p> <p><strong>Conclusions</strong>: Statistical significance appears to have influenced readers' perception whatever the level of spin, while spin influenced readers' perception when the results were not statistically significant but did not appear to have an impact when results were statistically significant</p>
Evaluation of Bioflex and Zirconia Crowns Versus Stainless Steel Crowns on Primary Molars: Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT07156838. IPD Sharing: NO. Countries: 1. Publications: 3.
American Ginseng to Improve HIV-Associated Fatigue: A Randomized, Placebo-Controlled, Parallel Design, Multiple-Dose Clinical Trial
ClinicalTrials.gov study NCT01500096. IPD Sharing: Not stated. Countries: 1. Publications: 2.
MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings
ClinicalTrials.gov study NCT05065502. IPD Sharing: YES. Countries: 1. Publications: 2.
Efficacy of the PEAC-IC: a Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT05081414. IPD Sharing: YES. Countries: 1. Publications: 8.
Hypnosis For Hot Flashes Among Postmenopausal Women in a Randomized Clinical Trial
ClinicalTrials.gov study NCT01293695. IPD Sharing: NO. Countries: 1. Publications: 2.
Double-Blind 2-Site Randomized Clinical Trial of Neurofeedback for ADHD
ClinicalTrials.gov study NCT02251743. IPD Sharing: NO. Countries: 1. Publications: 5.
Immediate Postplacental Insertion of IUDs at Time of Cesarean Delivery: A Randomized Clinical Trial
ClinicalTrials.gov study NCT01539759. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Volume Restriction in Esophageal Carcinoma Surgery: Randomized Clinical Trial
ClinicalTrials.gov study NCT02033213. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects Who Are Intolerant to Statins
ClinicalTrials.gov study NCT02135029. IPD Sharing: Not stated. Countries: 2. Publications: 2.
The Effects of Polymyxin-B Protects on Sepsis Induced Kidney Dysfunction: a Randomized Clinical Trial
ClinicalTrials.gov study NCT00490477. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Wearable Pulsed Electromagnetic Fields Device in Knee Osteoarthritis: Double Blinded, Randomized Clinical Trial
ClinicalTrials.gov study NCT01877278. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Randomized Clinical Trial on Hemoglobin Dose and Patient Matching
ClinicalTrials.gov study NCT01328262. IPD Sharing: NO. Countries: 1. Publications: 1.
A Randomized Clinical Trial of Alcohol Care Management
ClinicalTrials.gov study NCT00419315. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Prospective, Randomized, Parallel-arm Clinical Trial of CleanCision or Alexis O in Elective Colorectal Surgery
ClinicalTrials.gov study NCT03816995. IPD Sharing: NO. Countries: 1. Publications: 15.
A Randomized,Parallel-group Clinical Trial of Hepatitis B Vaccine With Different Dosages and Schedules in Healthy Adults
ClinicalTrials.gov study NCT02203357. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Randomized Clinical Trial: Expectant Management vs Laser Treatment of Monochorionic Twins With Severe Selective Intrauterine Growth Retardation and Absent or Reverse Diastolic Flow in the Umbilical Ar
ClinicalTrials.gov study NCT01177553. IPD Sharing: Not stated. Countries: 1. Publications: 32.
Randomized Trial of an Ambient AI Scribe (Voa Health) That Converts Outpatient Visit Audio Into Draft Notes, Comparing Visits With vs. Without AI Across Multiple Clinics to Assess Physician Well-being
ClinicalTrials.gov study NCT07302906. IPD Sharing: YES. Countries: 0. Publications: 5.
Reducing Cardiovascular Risk in Primary Care: a Randomized Clinical Trial
ClinicalTrials.gov study NCT05395806. IPD Sharing: YES. Countries: 1. Publications: 12.
A Physical Therapy Program Versus Surgery for Femoroacetabular Impingement: Randomized Clinical Trial
ClinicalTrials.gov study NCT01993615. IPD Sharing: YES. Countries: 1. Publications: 2.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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International Brain Laboratory public data
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OpenNeuro
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