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122 results for “reactive oxygen species”
Reactive Oxygen Species Following Aortic Valve Replacement
ClinicalTrials.gov study NCT02841917. IPD Sharing: NO. Countries: 1. Publications: 12.
Acute Hyperbaric Oxygen Treatment Increases Hepatic Insulin Sensitivity and Muscle Reactive Oxygen Species in T2D
ClinicalTrials.gov study NCT04219215. IPD Sharing: NO. Countries: 1. Publications: 1.
Reactive Oxygen Species in the Pathogenesis of Diabetic Complications
ClinicalTrials.gov study NCT00703989. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
ClinicalTrials.gov study NCT04334135. IPD Sharing: YES. Countries: 1. Publications: 1.
Reactive oxygen species produced by ultra-short electron pulses
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Data from: Ligation of glycophorin A generates reactive oxygen species leading to decreased red blood cell function
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Reactive oxygen species alter chemical composition and adsorptive fractionation of soil-derived organic matter
This is the data archive for the corresponding publication with the same title (doi: 10.1016/j.geoderma.2020.114805). Reactive oxygen species (ROS), formed during redox fluctuations in iron-rich soils, have been known to stimulate lignin degradation, although not much is known about how they alter soil organic matter (SOM) composition and interaction with mineral surfaces. We conducted a laboratory experiment to see how ROS altered SOM composition and adsorptive fractionation onto Fe-mineral surfaces. We reacted water extracts of SOM with ·OH, produced by the Fenton reaction, and then conducted a sorption experiment of the extracts with goethite to analyze the amount and quality of SOM adsorbed. The Fenton reaction preferentially consumed low-O, mostly aromatic molecules, and new high-O molecules were detected post-Fenton, nearly half of which were carbohydrate-like. Although the amount of C adsorbed did not change after oxidation, the post-Fenton adsorbed molecules were more oxidized. Pre-Fenton adsorption was dominated by aromatic molecules (90%), but post-Fenton, the adsorbed molecules were 75% aromatic and 25% carbohydrate-like. We show that the ·OH radical oxidized SOM and shifted patterns of adsorption to a more oxidized pool. Because adsorption to minerals is thought to stabilize SOM, our results suggest that ROS may alter the availability and stabilization patterns of SOM
Mitochondrial oxygen consumption and reactive oxygen species production in hepatopancreas mitochondria of Mya arenaria acclimated under different oxygen regimes
<p>These are the metadata for a publication "Effects of variable oxygen regimes on mitochondrial bioenergetics and reactive oxygen species production in a marine bivalve <em>Mya arenaria</em>" under consideration for publication in the Journal Of Experimental Biology. To study the impacts of different oxygen regimes, we exposed a common sediment-dwelling bivalve, the soft-shell clam <em>Mya arenaria</em>, for 21 days to chronic hypoxia (P<sub>O2</sub>~4.1 kPa), cyclic hypoxia (P<sub>O2</sub>~12.7-1.9 kPa, mean = 5.7 kPa), or normoxia (P<sub>O2</sub>~21.1 kPa). pH was manipulated to mimic the covariation in CO<sub>2</sub>/pH and oxygen levels in coastal hypoxic zones. Mitochondrial respiration, including the proton leak, the capacity for oxidative phosphorylation (OXPHOS), the maximum activity of the electron transport system (ETS), reactive oxygen species (ROS) production, and activity and oxygen affinity of cytochrome c oxidase (CCO) were assessed. Acclimation to constant hypoxia did not affect the studied mitochondrial traits except for a modest decrease in the OXPHOS coupling efficiency. Cyclic hypoxia had no effect on the OXPHOS or ETS capacity, but increased the proton leak and lowered the mitochondrial OXPHOS coupling efficiency. Furthermore, mitochondria of clams acclimated to cyclic hypoxia had higher rates of ROS generation compared with the clams acclimated to normoxia or chronic hypoxia. CCO activity was upregulated under the cyclic hypoxia, but oxygen affinity of CCO did not change. These findings indicate that long-term cyclic hypoxia has a stronger impact on the mitochondria of <em>M. arenaria</em> than chronic hypoxia and might lead to impaired ATP synthesis, higher costs of the mitochondrial maintenance and oxidative stress. These changes might negatively affect populations of <em>M. arenaria</em> in the coastal Baltic Sea under increasing hypoxia pressure.</p>
Data from: Hybridization increases mitochondrial production of reactive oxygen species in sunfish
Mitochondrial dysfunction and oxidative stress have been suggested to be possible mechanisms underlying hybrid breakdown, as a result of mito-nuclear incompatibilities in respiratory complexes of the electron transport system. However, it remains unclear whether hybridization increases the production of reactive oxygen species (ROS) by mitochondria. We used high-resolution respirometry and fluorometry on isolated liver mitochondria to examine mitochondrial physiology and ROS emission in naturally occurring hybrids of pumpkinseed (Lepomis gibbosus) and bluegill (L. macrochirus). ROS emission was greater in hybrids than in both parent species when respiration was supported by complex I (but not complex II) substrates, and was associated with increases in lipid peroxidation. However, respiratory capacities for oxidative phosphorylation, phosphorylation efficiency, and O2 kinetics in hybrids were intermediate between those in parental species. Flux control ratios of capacities for electron transport (measured in uncoupled mitochondria) relative to oxidative phosphorylation suggested that the limiting influence of the phosphorylation system is reduced in hybrids. This likely helped offset impairments in electron transport capacity and complex III activity, but contributed to augmenting ROS production. Therefore, hybridization can increase mitochondrial ROS production, in support of previous suggestions that mitochondrial dysfunction can induce oxidative stress and thus contribute to hybrid breakdown.
Measurement report: Impact of emission control measures on environmental persistent free radicals and reactive oxygen species – A short-term case study in Beijing
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Raw data for 'Engineered Lipids for Intracellular Reactive Oxygen Species Scavenging in Steatotic Hepatocytes'
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Data from: Hybridization increases mitochondrial production of reactive oxygen species in sunfish
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Data from: Individuals with higher metabolic rates have lower levels of reactive oxygen species hydrogen peroxide in vivo
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RNA-Seq transcriptome analysis of reactive oxygen species gene network in Mizuna plants grown in long-term space flight
Space environment is suspected to generate reactive oxygen species (ROS) and induce oxidative stress in plants however little is known about the gene expression of ROS gene network in plants grown in long-term space flight. RNA-Seq was used to define the large-scale gene expression profiles of Mizuna harvested after 27 days cultivation in the international space station to understand the molecular response and adaptation to space environment.Results: Total reads of transcripts from the Mizuna grown in the international space station as well as on the ground by RNA-Seq using next generation sequencing technology showed 8,258 and 14,170 transcripts up- and down-regulated in the space-grown Mizuna respectively when compared with those from the ground-grown Mizuna. A total of 20 in 32 ROS oxidative marker genes were up-regulated including high expression of 4 hallmarks and preferentially expressed gene associated with ROS-scavenging genes was thioredoxin glutaredoxin and alternative oxidase genes. In the transcription factors of ROS gene network MEKK1-MKK4-MPK3 OXI1-MKK4-MPK3 and OXI1-MPK3 of MAP cascades induction of WRKY22 by MEKK1-MKK4-MPK3 cascade induction of WRKY25 and repression of ZAT7 by Zat12 were suggested. RbohD and RbohF genes were up-regulated preferentially in NADPH oxidase genes which produce ROS.Conclusions: Our large-scale transcriptome analysis demonstrated that the space environment induced oxidative stress and ROS gene network was activated in the space-grown Mizuna some of which were common genes up-regulated by abiotic and biotic stress and were preferentially up-regulated genes by the space environment even though Mizuna grew in the space as well as on the ground showing that plants could acclimate to the space environment by reprograming the expression of ROS gene network.
Indoxyl sulfate stimulates angiogenesis by regulating reactive oxygen species production via CYP1B1
GEO Series GSE132410. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Ethanol enhances high-salinity stress tolerance by detoxification of reactive oxygen species in Arabidopsis and rice
GEO Series GSE95202. Arabidopsis thaliana. 16 samples. Type: Expression profiling by array.
Mitochondrial Dysfunction and Increased Reactive Oxygen Species Production in MECP2 Mutant Astrocytes and their Impact on Neurons
GEO Series GSE226975. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Metabolic regulation of cancer cell proliferation is mediated by reactive oxygen species
GEO Series GSE59736. Homo sapiens. 22 samples. Type: Expression profiling by array.
Disulfiram inhibits bacterial growth by inducing zinc-dependent reactive oxygen species
GEO Series GSE299097. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
Modulation of reactive oxygen species and inflammatory cytokines by FoxO3a promotes host survival against Salmonella typhimurium
GEO Series GSE82212. Mus musculus. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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