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698 results for “retina”
Physiological significance of the heterogeneous distribution of zeaxanthin and lutein in the retina of the human eye
<p>cross-sections of the human eye retina recorded with the FLIM technique and Raman microscopy</p>
DAPI stained Gonatus onyx retina
<p>(a) DAPI stained transverse cross-section of juvenile G. onyx (15mm ML) eye. Nuclei appear blue. (b) Enlarged section of b’ de-picting retinal layers. (c) Enlarged section of c’ depicting the iris. (d) Enlarged section of d’ depicting the transition from the retina to the ciliary body, and view of the cartilaginous part of the sclera. Abbreviations: dorsal (do), ventral (ve), posterior (po), anterior (an), inner segment of photoreceptor (isp), basal membrane (bm), supporting cells (sc), outer segment of photoreceptor (osp), limiting membrane (lm), sclera (s). </p>
Imágenes de microscopía de expansión de células ganglionares de retina de ratón
<p>La conectividad en los circuitos ganglionares de la retina (RGC) es tan diversa como la morfología y función de las diferentes células ganglionares formando diferentes circuitos sinápticos. Los estudios de circuitos de las RGCs se beneficiarán de la aplicación de nuevas herramientas para la obtención de imágenes de super resolución con información de moléculas detectadas in situ. Las imágenes volumétricas de fluorescencia de super resolución por microscopía de expansión son una estrategia para la preparación de muestras biológicas que permiten descubrir estructuras diminutas al expandirlas con una red de polímeros. La idea es polimerizar esta red en muestras de tejido y luego expandir físicamente esta red con agua para agrandar las estructuras biológicas. Entre otras ventajas, la microscopía de expansión hace posible escanear esas diminutas estructuras utilizando métodos de microscopía estándar. Esta estrategia ha sido utilizada para el análisis nanométrico de las propiedades sinápticas en tejido nervioso. Nuestro enfoque experimental describe protocolos optimizados de microscopía de expansión para la detección tanto de las células ganglionares de la retina, como la de proteínas sinápticas por inmunohistoquímica. En este trabajo, describimos nuestro enfoque experimental para estudiar la conectividad sináptica de las células ganglionares de la retina del ratón combinando el marcaje celular de las células ganglionares, la detección de proteínas sinápticas por inmuno histoquímica y microscopía de expansión para lograr un aumento isotrópico de ~ 4x en la resolución espacial. Usando ratones TIGRE 2.0 dependiente de cre y ratones reporteros de desplazamiento de marco repetido de mononucleótido (MORF), promovemos expresión de una proteína fluorescente en estas células (Opn4Cre). Combinamos este marcaje celular con anticuerpos contra las proteínas presinápticas (vGAT) y postsinápticas (GlyR) para caracterizar la organización molecular de la inhibición de las células amacrinas sobre las células ganglionares de la retina ON alfa.</p> <p> </p> <p> </p>
RETINAS: experimental data
<p>Data set of the "measuring G" experiment. Parameters:</p> <ul> <li>Number of horizontal pixels: 256</li> <li>Number of vertical pixels: 128</li> <li>Capture rate: 470 Hz</li> <li>Capture duration: 10 minutes</li> <li>Upsampling factor: 256</li> <li>Offset: 100</li> </ul>
Data from: Awake responses suggest inefficient dense coding in the mouse retina
<p><span>The structure and function of the vertebrate retina have been extensively studied across species with an isolated, <em>ex vivo</em> preparation. Retinal function <em>in vivo</em>, however, remains elusive, especially in awake animals. Here we performed single-unit extracellular recordings in the optic tract of head-fixed mice to compare the output of awake, anesthetized, and <em>ex vivo </em>retinas. While the visual response properties were overall similar across conditions, we found that awake retinal output had in general 1) faster kinetics with less variability in the response latencies; 2) a larger dynamic range; and 3) higher firing activity, by ~20 Hz on average, for both baseline and visually evoked responses. Our modeling analyses further showed that such awake response patterns convey comparable total information but less efficiently, and allow for a linear population decoder to perform significantly better than the anesthetized or <em>ex vivo</em> responses. These results highlight distinct retinal behavior in awake states, in particular suggesting that the retina employs dense coding <em>in vivo</em>, rather than sparse efficient coding as has been often assumed from<em> ex vivo</em> studies.</span></p>
Evaluation of Retina in Patients With Glaucoma Using Topical Prostaglandins Undergoing Trabeculectomy Surgery
ClinicalTrials.gov study NCT06000280. IPD Sharing: YES. Countries: 1. Publications: 34.
Effects of Differences in Body Composition on Retina and Choroid
ClinicalTrials.gov study NCT06888765. IPD Sharing: NO. Countries: 1. Publications: 3.
The Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the Choroid
ClinicalTrials.gov study NCT06708013. IPD Sharing: YES. Countries: 1. Publications: 1.
Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina
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Data from: Awake responses suggest inefficient dense coding in the mouse retina
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Quantifying the influence of optical coherence tomography beam tilt in the normal adult mouse retina
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Compromised 2-start zigzag chromatin folding in immature mouse retina cells driven by irregularly spaced nucleosomes with short DNA linkers
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Data from: Pushing the limits of photoreception in twilight conditions: The rod-like cone retina of the deep-sea pearlsides
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Data from: Is retina affected in Huntington's disease? Is optical coherence tomography a good biomarker?
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Serial block face scanning electron micrographs of mouse outer retina
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Amacrine cells differentially balance zebrafish colour circuits in the central and peripheral retina
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Data from: Oxidative stress in the retina and retinal pigment epithelium (RPE): role of aging, and DJ-1
<p>High levels of oxidative radicals generated by daily light exposure and high metabolic rate suggest that the antioxidant machinery of the retina and retinal pigment epithelium (RPE) is crucial for their survival. DJ-1 is a redox-sensitive protein that has been shown to have neuroprotective function in the brain in Parkinson's disease and other neurodegenerative diseases. Here, we analyzed the role of DJ-1 in the retina during oxidative stress and aging. We induced low-level oxidative stress in young (3-month-old) and old (15-month-old) C57BL/6J (WT) and DJ-1 knockout (KO) mice and evaluated effects in the RPE and retina. Absence of DJ-1 resulted in increased retinal dysfunction in response to low levels of oxidative stress. Our findings suggest that loss of DJ-1 affects the RPE antioxidant machinery, rendering it unable to combat and neutralize low-level oxidative stress, irrespective of age. Moreover, they draw a parallel to the retinal degeneration observed in AMD, where the occurrence of genetic variants may leave the retina and RPE unable to fight sustained, low-levels of oxidative stress.</p>
Nonresonant Raman spectroscopy of isolated human retina samples complying with laser safety regulations for in vivo measurements
<p>Raman raw data for the paper "Nonresonant Raman spectroscopy of isolated human retina samples complying with laser safety regulations for in vivo measurements"</p> <ul> <li>two sets of unprocessed Raman spectra recorded under restricted conditions as seen in Figure 5(b)</li> <li>each spectrum was recorded at 785 nm with 1 mW laser power and 10 s integration time</li> </ul>
The visual ecology of Holocentridae, a nocturnal coral reef fish family with a deep-sea-like multibank retina
<p>The visual systems of teleost fishes usually match their habitats and lifestyles. Since coral reefs are bright and colourful environments, the visual systems of their diurnal inhabitants have been more extensively studied than those of nocturnal species. In order to fill this knowledge gap, we conducted a detailed investigation of the visual system of the nocturnal reef fish family Holocentridae. Results showed that the visual system of holocentrids is well adapted to their nocturnal lifestyle with a rod-dominated retina. Surprisingly, rods in all species were arranged into 6-17 well-defined banks, a feature most commonly found in deep-sea fishes, that may increase the light sensitivity of the eye and/or allow colour discrimination in dim-light. Holocentrids also have the potential for dichromatic colour vision during the day with the presence of at least two spectrally different cone types: single cones expressing the blue-sensitive <i>SWS2A</i> gene, and double cones expressing one or two green-sensitive <i>RH2</i> genes. Some differences were observed between the two subfamilies, with Holocentrinae (squirrelfish) having a slightly more developed photopic visual system than Myripristinae (soldierfish). Moreover, retinal topography of both ganglion cells and cone photoreceptors showed specific patterns for each cell type, likely highlighting different visual demands at different times of the day, such as feeding. Overall, their well-developed scotopic visual systems and the ease of catching and maintaining holocentrids in aquaria, make them ideal models to investigate teleost dim-light vision and more particularly shed light on the function of the multibank retina and its potential for dim-light colour vision.</p>
Comprehensive single-cell atlas of the mouse retina
<p><strong>Abstract:</strong></p> <p>Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellular heterogeneity at the single-cell resolution by classifying and characterizing cell types in multiple tissues and species. While several mouse retinal scRNA-seq reference datasets have been published, each dataset either has a relatively small number of cells or is focused on specific cell classes, and thus is suboptimal for assessing gene expression patterns across all retina types at the same time. To establish a unified and comprehensive reference for the mouse retina, we first generated the largest retinal scRNA-seq dataset to date, comprising approximately 190,000 single cells from C57BL/6J mouse whole retinas. This dataset was generated through the targeted enrichment of rare population cells via antibody-based magnetic cell sorting. By integrating this new dataset with public datasets, we conducted an integrated analysis to construct the Mouse Retina Cell Atlas (MRCA) for wild-type mice, which encompasses over 330,000 single cells. The MRCA characterizes 12 major classes and 138 cell types. It captured consensus cell type characterization from public datasets and identified additional new cell types. To facilitate the public use of the MRCA, we have deposited it in CELLxGENE, UCSC Cell Browser, and the Broad Single Cell Portal for visualization and gene expression exploration. The comprehensive MRCA serves as an easy-to-use, one-stop data resource for the mouse retina communities.</p> <p> </p> <p><strong>Data description:</strong></p> <p>1. MRCA: scRNA-seq of the mouse retina - all cells<br>This file contains the full 330K single cells of the MRCA.<br><br>2. MRCA: scRNA-seq of the mouse retina - bipolar cell subclass<br>This file contains 147K single cells for bipolar cell subcass of the MRCA.</p> <p>3. MRCA: scRNA-seq of the mouse retina - RGC subclass<br>This file contains 77K single cells for retinal ganglion cell subclass of the MRCA.</p> <p>4. MRCA: scRNA-seq of the mouse retina - amacrine cell subclass<br>This file contains 43K single cells for amacrine cell subclass of the MRCA.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.