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183
datasets available to search
ShareScore release 0.9.0
Dataset results
183 results for “secretome”
Alterations of Muscle Secretome Associated With Muscle Atrophy Caused by Glucocorticoids
ClinicalTrials.gov study NCT03229395. IPD Sharing: NO. Countries: 1. Publications: 15.
Potential Injection of Human Umbilical Cord Secretome in the Case of Trophic Ulcers (Pre-post Intervention)
ClinicalTrials.gov study NCT05777213. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Secretome TGF Beta 3
ClinicalTrials.gov study NCT07137130. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Impact of Changes in Muscle Secretome in the Remission of Type 2 Diabetes Mellitus Induced by Bariatric Surgery
ClinicalTrials.gov study NCT03341793. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
The Effects of Mesenchymal Stem Cell Secretome in Rheumatoid Arthritis Patients
ClinicalTrials.gov study NCT05925647. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
ClinicalTrials.gov study NCT05204329. IPD Sharing: Not stated. Countries: 1. Publications: 22.
Effects of ASC Secretome on Human Osteochondral Explants
ClinicalTrials.gov study NCT04223622. IPD Sharing: NO. Countries: 1. Publications: 2.
Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Moderate Neurocognitive Impairment (Dementia)
ClinicalTrials.gov study NCT06632470. IPD Sharing: YES. Countries: 1. Publications: 20.
Treatment of Severe COVID-19 Patients Using Secretome of Hypoxia-Mesenchymal Stem Cells in Indonesia
ClinicalTrials.gov study NCT04753476. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
The effect of intra-articular injection of secretome of umbilical cord mesenchymal stem cells in articular cartilage repair in sheep model
<p><b>Introduction: </b>Articular cartilage is an avascular, aneural, and alymphatic tissue that has limited capacity to regenerate. Numerous techniques have been employed to repair or regenerate; however, the success rate varies. In fact, most of them result in the formation of fibrocartilage, not hyaline cartilage. The future of treating cartilage defects lies in providing biologic solutions through cartilage regeneration. Mesenchymal stem cells (MSCs) represent a promising therapy for cartilage regeneration. These cells secrete factors that enhance cartilage repair. In this study, the effects of intra-articular injection of human umbilical cord MSC (hUC-MSC) secretome on cartilage damage was studied in a sheep model.</p> <p><b>Methods: </b>Standardized rectangular (5x5 mm) full-thickness chondral defects were created in the lateral femoral condyle of 15 adult sheep and debrided down to the subchondral bone plate. Three treatment groups were tested: 4 microfracture perforations using 1.0mm diameter awls (group 1), intra-articular injection of hUC-MSC secretome (group 2), and combination of microfracture and intra-articular injection of hUC-MSC secretome (group 3). Osteochondral repair was assessed at 6 months in vivo using established macroscopic and histological analyses.</p> <p><b>Results: </b><b></b> Macroscopically, application of combined therapy shows significant improvement of cartilage repair compared to microfracture alone (p=0.004). Microscopically, the application of combined therapy shows significant improvement of cartilage repair compared to secretome injection alone (p=0.031)</p> <p><b>Conclusion:</b> Microfracture combined with injection of hUCB-MSCs secretome could be an effective alternative for repairing articular cartilage defects in vivo.</p>
Role of Hypoxic Secretome from Mesenchymal Stem Cells in Enhancing Tissue Repair: Regulatory Effects on HIF-1α, VEGF, and Fibroblast in a Sphincterotomy Rat Model
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Dataset related to article "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"
<p>Dataset related to manuscript "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"</p> <p>Each excel file contains raw data relative to data shown in Figures</p>
The Endocrine Secretome After Gastric Bypass Surgery
ClinicalTrials.gov study NCT03093298. IPD Sharing: UNDECIDED. Countries: 0. Publications: 3.
A Phase II/III Randomized Double-Blind Multicenter Study Comparing UC-MSC-Derived Secretome and Sodium Hyaluronate in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT07337863. IPD Sharing: YES. Countries: 1. Publications: 0.
The effect of intra-articular injection of secretome of umbilical cord mesenchymal stem cells in articular cartilage repair in sheep model
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A secretome CRISPR screen identifies SFRP1 as a regulator of epidermal self-renewal [RNA-seq]
GEO Series GSE269627. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
p21 produces a bioactive secretome that places stressed cells under immuno-surveillance [dataset 9]
GEO Series GSE139575. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
The Senescence-associated Secretome of Hedgehog-deficient Hepatocytes Drives MASLD Progression
GEO Series GSE273523. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Multiplex secretome engineering enhances recombinant protein production and purity
GEO Series GSE144624. Cricetulus griseus. 18 samples. Type: Expression profiling by high throughput sequencing.
Microglia actively remodels adult hippocampal neurogenesis through the phagocytosis secretome
GEO Series GSE129569. Mus musculus. 9 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.