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38
datasets available to search
ShareScore release 0.9.0
Dataset results
38 results for “serotonin transporter”
Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients
ClinicalTrials.gov study NCT01936051. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms
ClinicalTrials.gov study NCT04101227. IPD Sharing: NO. Countries: 7. Publications: 0.
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression
ClinicalTrials.gov study NCT02132286. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Serotonin Transporter in Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov study NCT01108354. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Serotonin Transporter Inhibitor Escitalopram in Pulmonary Hypertension
ClinicalTrials.gov study NCT00190333. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET
ClinicalTrials.gov study NCT06476509. IPD Sharing: NO. Countries: 1. Publications: 0.
Serotonin Transporter Concentrations in Women With a History of Anorexia Nervosa
ClinicalTrials.gov study NCT00320684. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Serotonin Transporter Genetic Variation and Amygdalar Activation Correlates of Antidepressant Response
ClinicalTrials.gov study NCT00456430. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
GEO Series GSE246540. Mus musculus. 129 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Gene x environment effect of serotonin transporter genotype and acute stressor on amygdala gene expression
GEO Series GSE40393. Mus musculus. 20 samples. Type: Expression profiling by array.
Disruption of the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast Cell
GEO Series GSE304347. Mus musculus. 31 samples. Type: Expression profiling by high throughput sequencing.
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [ChIP-seq]
GEO Series GSE246538. Mus musculus. 84 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Serotonin Transporter Density in Late-life Depression With and Without Dementia
ClinicalTrials.gov study NCT01548937. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Gene Expression and Histopathological Changes in the Placenta of the Serotonin Transporter (Slc6a4) Knockout Mouse Suggest a Role for Serotonin in Controlling Nutrient Acquisition
GEO Series GSE175489. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression analysis of serotonin transporter knock-out and wildtype rats during rat postnatal prefrontal cortex development
GEO Series GSE79909. Rattus norvegicus. 50 samples. Type: Expression profiling by high throughput sequencing.
The serotonin transporter is a regulator of neurodegeneration and axon regeneration after retinal injury
GEO Series GSE153812. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Respiratory Sinus Arrhythmia (RSA) stress response in preschool age varies by serotonin transporter polymorphism (5-HTTLPR): A preliminary report
<p>The serotonin transporter promoter region polymorphism (5-HTTLPR) has been implicated in stress regulation, with increased stress reactivity often being found in carriers of the low-expressing short (S) allele. Nevertheless, the role of the 5-HTTLPR in influencing parasympathetic stress reactivity, as indexed by Respiratory Sinus Arrhythmia (RSA), is still unknown. This study examined, for the first time, whether the 5-HTTLPR was associated with variations in RSA response to maternal separation in a sample of 69 healthy 5-year-old children. Preschoolers' RSA was measured during an age-adapted version of the Strange Situation Procedure (SSP). The 5-HTTLPR polymorphism was tested as a predictor of RSA dynamic response to the SSP through multilevel models. A significant interaction between 5-HTTLPR and SSP episodes was found. In particular, whereas a significant decrease in RSA levels was observed during the stranger episode in the whole sample, S allele carriers showed a significant decrease in RSA levels from the stranger episode to the first separation episode, followed by an increase for the rest of the procedure. Albeit preliminary, data support the view that the 5-HTTLPR may contribute to individual differences in RSA stress reactivity from preschool age.</p>
Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns
<p>This database includes the raw data linked with the paper “Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns” accepted for publication on Molecular Psychiatry. This study is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” study. Here, we report on the interactive influence of variations in antenatal exposures to maternal pandemic-related stress (PRS) and PM2.5 on SLC6A4 DNAm levels in newborns.</p> <p>Procedures</p> <p>Mother–infant dyads (N=307) were enrolled at delivery during the COVID-19 pandemic. Infants’ methylation status was assessed in 13 CpG sites within the SLC6A4 gene’s region (chr17:28562750–28562958) in buccal cells at birth and women retrospectively report on PRS. PM2.5 exposure throughout the entire gestation and at each gestational trimester was estimated using a spatiotemporal model based on residential address.</p> <p> </p> <p>Among several potentially confounding socio-demographic and health-related factors, infant’s sex was significantly associated with infants’ SLC6A4 DNAm levels, thus hierarchical regression models were adjusted for infant’s sex.</p> <p>Mother–infant dyads (N = 276) were recruited at delivery. Maternal trait anxiety, as a marker of antenatal chronic stress exposure, was assessed soon after delivery using the Stait-Trait Anxiety Inventory (STAI-Y). Infants’ BDNF DNAm at birth was assessed in 11 CpG sites in buccal cells whereas infants’ NE was assessed at 3 (N = 225) and 6 months (N = 189) using the Infant Behavior Questionnaire-Revised (IBQ-R).</p> <p>Analytical plan</p> <p>Principal component analysis (PCA) was used to reduce the number of CpG sites into a smaller set of factors.</p> <p>A four-factor solution, where the targeted CpG sites were aggregated in 4 main factors, showed the best fit to the data (Table 2). Principal Component 1 (PC1; composed of 6 CpG sites) and Principal Component 2 (PC2; composed of 3 CpG sites) accounted, respectively, for 31.6% and 12.8% of the total variance in SLC6A4 DNAm and were used in further analyses. Pearson correlations and independent samples t-tests were employed to explore the potential effect of sociodemographic and health-related variables on infant methylation levels. All variables found to be significantly associated with the outcomes examined were included as covariates in subsequent analyses. Separate hierarchical regression analyses were performed to evaluate the independent and interactive effects of maternal PRS and exposure to air pollution on infant methylation levels.</p> <p>Findings in brief</p> <p>Higher levels of SLC6A4 DNAm at 6 CpG sites were found in newborns born to mothers reporting higher levels of antenatal PRS and greater PM2.5 exposure across gestation, while adjusting for infant’s sex. These effects were especially evident when exposure to elevated PM2.5 occurred during the second trimester of pregnancy.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.