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44 results for “siderophore”
Data from: Genetic architecture constrains exploitation of siderophore cooperation in the bacterium Burkholderia cenocepacia.
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Siderophore-mediated interactions determine the disease suppressiveness of microbial consortia
<p>Interactions between plant pathogens and root-associated microbes play an important role in determining disease outcomes. While several studies have suggested that steering these interactions may improve plant health, such approaches have remained challenging in practice. Because of low iron availability in most soils, competition for iron via secreted siderophore molecules might influence microbial interaction outcomes.Here we tested if bacterial interactions mediated by iron-scavenging siderophores can be used to predict the disease suppressiveness of microbial consortia against soil-borne <i>Ralstonia solanacearum</i> bacterial pathogen in tomato rhizosphere. Iron availability significantly affected the interactions within inoculated consortia and between the consortia and the pathogen. We observed contrasting effects of siderophores and other non-siderophore metabolites on the pathogen growth, while the siderophore effects were relatively much stronger. Specifically, disease incidence was reduced <i>in vivo </i>when the inoculated consortia produced siderophores that the pathogen could not use for its own growth. Employing siderophore-mediated interactions to engineer functionally robust microbial inoculants show promise in protecting plants from soil-borne pathogens.</p>
Data from: Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production
Bacteria produce a wide variety of exoproducts that favourably modify their environment and increase their fitness. These are often termed 'public goods' because they are costly for individuals to produce and can be exploited by non-producers (cheats). The outcome of conflict over public goods is dependent upon the prevailing environment and the phenotype of the individuals in competition. Many bacterial species use quorum sensing (QS) signalling molecules to regulate the production of public goods. QS, therefore, determines the cooperative phenotype of individuals, and influences conflict over public goods. In addition to their regulatory functions, many QS molecules have additional properties that directly modify the prevailing environment. This leads to the possibility that QS molecules could influence conflict over public goods indirectly through non-signalling effects, and the impact of this on social competition has not previously been explored. The Pseudomonas aeruginosa QS signal molecule PQS is a powerful chelator of iron which can cause an iron starvation response. Here, we show that PQS stimulates a concentration-dependent increase in the cooperative production of iron scavenging siderophores, resulting in an increase in the relative fitness of non-producing siderophore cheats. This is likely due to an increased cost of siderophore output by producing cells and a concurrent increase in the shared benefits, which accrue to both producers and cheats. Although PQS can be a beneficial signalling molecule for P. aeruginosa, our data suggest that it can also render a siderophore-producing population vulnerable to competition from cheating strains. More generally, our results indicate that the production of one social trait can indirectly affect the costs and benefits of another social trait.
Data from: Dynamic social behaviour in a bacterium: Pseudomonas aeruginosa partially compensates for siderophore loss to cheats
Cooperation underlies diverse phenomena including the origins of multicellular life, human behaviour in economic markets and the mechanisms by which pathogenic bacteria cause disease. Experiments with microorganisms have advanced our understanding of how, when and why cooperation evolves, but the extent to which microbial cooperation can recapitulate aspects of animal behaviour is debated. For instance, understanding the evolution of behavioural response rules (how should one individual respond to another's decision to cooperate or defect?) is a key part of social evolution theory, but the possible existence of such rules in social microbes has not been explored. In one specific context (biparental care in animals), cooperation is maintained if individuals respond to a partner's defection by increasing their own investment into cooperation, but not so much that this fully compensates for the defector's lack of investment. This is termed 'partial compensation.' Here, I show that partial compensation for the presence of non-cooperating 'cheats' is also observed in a microbial social behaviour: the cooperative production of iron-scavenging siderophores by the bacterium Pseudomonas aeruginosa. A period of evolution in the presence of cheats maintains this response, whereas evolution in the absence of cheats leads to a loss of compensatory behaviour. These results demonstrate i) the remarkable flexibility of bacterial social behaviour; ii) the potential generality of partial compensation as a social response rule; and iii) the need for mathematical models to explore the evolution of response rules in multi-player social interactions.
Data from: Evolutionary dynamics of interlinked public goods traits: an experimental study of siderophore production in Pseudomonas aeruginosa
Public goods cooperation is common in microbes, and there is much interest in understanding how such traits evolve. Research in recent years has identified several important factors that shape the evolutionary dynamics of such systems, yet few studies have investigated scenarios involving interactions between multiple public goods. Here we offer general predictions about the evolutionary trajectories of two public goods traits having positive, negative or neutral regulatory influence on one another's expression, and we report on a test of some of our predictions in the context of Pseudomonas aeruginosa's production of two interlinked iron-scavenging siderophores. First, we confirmed that both pyoverdine and pyochelin siderophores do operate as public goods under appropriate environmental conditions. We then tracked their production in lines experimentally evolved under different iron-limitation regimes known to favour different siderophore expression profiles. Under strong iron limitation, where pyoverdine represses pyochelin, we saw a decline in pyoverdine and a concomitant increase in pyochelin – consistent with expansion of pyoverdine-defective cheats derepressed for pyochelin. Under moderate iron limitation, pyochelin declined – again consistent with an expected cheat invasion scenario – but there was no concomitant shift in pyoverdine because cross-suppression between the traits is unidirectional only. Alternating exposure to strong and moderate iron-limitation caused qualitatively similar though lesser shifts compared to the constant-environment regimes. Our results confirm that the regulatory inter-connections between public goods traits can significantly modulate the course of evolution, yet also suggest how we can start to predict the impacts such complexities will have on phenotypic divergence and community stability.
Copper selects for siderophore-mediated virulence in Pseudomonas aeruginosa: data
<p>Data for the paper entitled 'Copper selects for siderophore-mediated virulence in Pseudomonas aeruginosa'. Columns are:</p> <p>- copper: 1 = no copper control, 2 = 0.1g/L copper sulphate, 3 = 1.0g/L copper sulphate.</p> <p>- rep: rep identifier to allow control of repeated sampling</p> <p>- death: the number of larvae dead out of 20</p> <p>- pyo: the amount of pyoverdine in the sample. Values of sterile media are already subtracted from these readings.</p> <p>- od: the optical density of each sample. Values of sterile media are already subtracted from these readings.</p> <p>- tp: timepoint. 1 = 2 days, 2 = 12 days</p> <p>- cfu: the number of colony forming units per 25µL of freezer stock. This is made with 50% glycerol.</p> <p>- strain: wildtype = a pyoverdine and pyochelin producer, mutant = a non-producer</p>
The Cytoscape session file for the network of siderophore BGCs predicted from Streptomyces genomes
<p>The Cytoscape session file for the network of siderophore BGCs predicted from Streptomyces genomes</p>
Plant-derived catechols are substrates of TonB-dependent transporters and sensitize Pseudomonas aeruginosa to siderophore-drug conjugates
<p>The dataset contains raw data used to generate the figures of the associated mansucript</p>
Fig. 7 in Feature-based molecular networking-guided discovery of siderophores from a marine mesophotic zone Axinellida sponge-associated actinomycete Streptomyces diastaticus NBU2966
Fig. 7. Experimental and calculated ECD spectra of compounds 5, 6, 7, 9, and 10.
Fig. 4 in Feature-based molecular networking-guided discovery of siderophores from a marine mesophotic zone Axinellida sponge-associated actinomycete Streptomyces diastaticus NBU2966
Fig. 4. Putative mechanism leading to the formation of epimers in 5 and 9.
Fig. 3 in Feature-based molecular networking-guided discovery of siderophores from a marine mesophotic zone Axinellida sponge-associated actinomycete Streptomyces diastaticus NBU2966
Fig. 3. The key COSY and HMBC correlations of 5, 6, 7, 9, and 10.
Siderophore-mediated interactions determine the disease suppressiveness of microbial consortia
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Data from: Siderophore cooperation of the bacterium Pseudomonas fluorescens in soil
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Data from: Evolutionary dynamics of interlinked public goods traits: an experimental study of siderophore production in Pseudomonas aeruginosa
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Data from: Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production
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Data from: Dynamic social behaviour in a bacterium: Pseudomonas aeruginosa partially compensates for siderophore loss to cheats
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RGS4 impacts carbohydrate and siderophore metabolism in Trichoderma reesei
GEO Series GSE216955. Trichoderma reesei. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis in simulated microgravity unveils down-regulation of the beta-rhizobial siderophore phymabactin
GEO Series GSE255155. Paraburkholderia phymatum STM815. 6 samples. Type: Expression profiling by high throughput sequencing.
Molecular signatures of the Eagle effect induced by the artificial siderophore conjugate LP-600 in E. coli
GEO Series GSE197880. Escherichia coli. 18 samples. Type: Expression profiling by high throughput sequencing.
Siderophores for Imaging Infection Using 68Ga-DFO
ClinicalTrials.gov study NCT05285072. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.