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Dataset results
169 results for “sustained release”
Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme
<p>Malignant gliomas are a type of primary brain tumour that originates in glial cells. Among them, glioblastoma multiforme (GBM) is the most common and the most aggressive brain tumour in adults, classified as grade IV by the World Health Organization. The standard care for GBM, known as the Stupp protocol includes surgical resection followed by oral chemotherapy with temozolomide (TMZ). This treatment option provides a median survival prognosis of only 16–18 months to patients mainly due to tumour recurrence. Therefore, enhanced treatment options are urgently needed for this disease. Here we show the development, characterization, and in vitro and in vivo evaluation of a new composite material for local therapy of GBM post-surgery. We developed responsive nanoparticles that were loaded with paclitaxel (PTX), and that showed penetration in 3D spheroids and cell internalization. These nanoparticles were found to be cytotoxic in 2D (U-87 cells) and 3D (U-87 spheroids) models of GBM. The incorporation of these nanoparticles into a hydrogel facilitates their sustained release in time. Moreover, the formulation of this hydrogel containing PTX-loaded responsive nanoparticles and free TMZ was able to delay tumour recurrence in vivo after resection surgery. Therefore, our formulation represents a promising approach to develop combined local therapies against GBM using injectable hydrogels containing nanoparticles.</p>
Comparative Efficacy and Safety of Sitagliptin Phosphate Combined with Gliclazide Sustained-Release Tablets Versus Metformin in Treatment-Naïve Patients with Type 2 Diabetes Mellitus and Glucotoxicity: A Single-Center, Prospective, Randomized Controlled Non-Inferiority Study
<p>This dataset supports the manuscript titled "Comparative Efficacy and Safety of Sitagliptin Phosphate Combined with Gliclazide Sustained-Release Tablets Versus Metformin in Treatment-Naïve Patients with Type 2 Diabetes Mellitus and Glucotoxicity: A Single-Center, Prospective, Randomized Controlled Non-Inferiority Study." The study aims to compare the efficacy and safety of sitagliptin phosphate combined with gliclazide sustained-release tablets against metformin in treatment-naïve patients with type 2 diabetes mellitus and glucotoxicity. Data include clinical measurements, laboratory test results, and adverse event records collected throughout the trial period. Statistical analyses were conducted to assess non-inferiority between the two treatment groups. This dataset provides valuable insights for researchers interested in diabetes management, pharmacotherapy, and randomized controlled trials.</p>
Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects
ClinicalTrials.gov study NCT02641301. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke
ClinicalTrials.gov study NCT00307203. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study Evaluating the Long-Term Safety of Desvenlafaxine Succinate Sustained-Release (DVS SR) in Subjects With Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT01050218. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Randomized, Active-controlled, Parallel, Open-label, Multicenter, Phase 4 Study to Compare the Efficacy and Safety of Pregabalin Sustained Release Tablet and Pregabalin Immediate Release Capsule in
ClinicalTrials.gov study NCT05624853. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in Combination With an Antidepressant in the Treatment of Major Depressive Disorders
ClinicalTrials.gov study NCT00326105. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Compare the Effects of Lercanidipine Hydrochloride Tablet (Zanidip®) and Felodipine Sustained-Release Tablet for Hypertension
ClinicalTrials.gov study NCT01520285. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
ClinicalTrials.gov study NCT05529927. IPD Sharing: YES. Countries: 0. Publications: 2.
A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine
ClinicalTrials.gov study NCT00314340. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals
ClinicalTrials.gov study NCT00429767. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive Disorders
ClinicalTrials.gov study NCT00326144. IPD Sharing: Not stated. Countries: 1. Publications: 6.
A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome
ClinicalTrials.gov study NCT00675896. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating Desvenlafaxine Succinate Sustained Release In Outpatients With Major Depressive Disorder
ClinicalTrials.gov study NCT00824291. IPD Sharing: Not stated. Countries: 0. Publications: 9.
Clinical Trial of Systolic Heart Failure Treatment of IvabRadine Hemisulfate Sustained-release Tablets （FIRST）
ClinicalTrials.gov study NCT02188082. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate Safety and Pharmacokinetics/Pharmacodynamics of Sustained Release(SR) Exenatide
ClinicalTrials.gov study NCT00964262. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Pregabalin Sustained Release Tablet for Postherpetic Neuralgia
ClinicalTrials.gov study NCT02868801. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Randomized Trial of Ultrashort Psychotherapy vs Sustained-Release Bupropion for Smoking Cessation
ClinicalTrials.gov study NCT00484692. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating Desvenlafaxine Sustained-Release (DVS-SR) in Adult Outpatients With Major Depressive Disorder
ClinicalTrials.gov study NCT00277823. IPD Sharing: Not stated. Countries: 1. Publications: 7.
A Study of Adjuvant NDV-01 (Sustained-release Gemcitabine-docetaxel) for the Treatment of Intermediate Risk NMIBC Following TURBT
ClinicalTrials.gov study NCT07313891. IPD Sharing: NO. Countries: 0. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.