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ShareScore release 0.9.0
Dataset results
672 results for “systemic diseases”
Literature search on worldwide surveillance systems targeting transboundary zoonotic and emerging diseases
<p>Surveillance systems for zoonotic and transboundary emerging pathogens that are structured following the holistic principles of joint work efforts from the human health, animal health and environmental health sectors are reviewed to provide a summary of one-health based surveillance systems existing worldwide. A systematic search of available literature was undertaken across various biomedical and scientific literature databases (from 2000 to 2022) and were selected using inclusion/exclusion criteria to filter references presenting systematic surveillance systems applicable to transmissible, transboundary, and zoonotic diseases operating under the One Health approach. A standardized data model and vocabulary were used to extract and classify key information to characterize target surveillance systems. 996 studies were obtained after research (589 after duplicates’ elimination) for inclusion in this review and information was extracted using a data model, which were reduced to 79 items once inclusion and exclusion criteria were applied. From these articles, 80 additional items were found within references.</p>
Data set related to the article: "The Role of BPIFB4 in Immune System and Cardiovascular Disease: The Lesson from Centenarians."
<p>Abstract:</p> <p>Recent discoveries have shed light on the participation of the immune system in the physio pathology of the car- diovascular system underpinning the importance of keeping the balance of the first to preserve the latter. Aging, along with other risk factors, can challenge such balance triggering the onset of cardiovascular diseases.</p> <p>Among several mediators ensuring the proper cross-talk between the two systems, bactericidal/permeability- increasing fold-containing family B member 4 (BPIFB4) has been shown to have a pivotal role, also by sustaining important signals such as eNOS and PKC-alpha.</p> <p>In addition, the Longevity-associated variant (LAV), which is an haplotype allele in BPIFB4 characterized by 4 missense polymorphisms, enriched in homozygosity in Long Living Individuals (LLIs), has been shown to be efficient, if admin- istered systemically through gene therapy, in improving many aspects of cardiovascular diseases (CVDs). This occurs mainly through a fine immune system remodeling across: 1) a M2 macrophage polarizing effect, 2) a favorable redistri- bution of the circulating monocyte cell subsets and 3) the reduction of T-cell activation. Furthermore, LAV-BPIFB4 treat- ment induced a desirable recovery of the inflammatory balance by mitigating the pro-inflammatory factor levels and enhancing the anti-inflammatory boost through a mechanism that is partially dependent on SDF-1/CXCR4 axis.</p> <p>Importantly, the remarkable effects of LAV-BPIFB4 treatment, which translates in increased BPIFB4 circulating levels, mirror what occurs in long-living individuals (LLIs) in whom the high circulating levels of BPIFB4 are protective from age-related and CVDs and emphasize the reason why LLIs are considered a model of successful aging. Here, we review the mechanisms by which LAV-BPIFB4 exerts its immunomodulatory activity in improving the cardiovascular-immune system dialogue that might strengthen its role as a key mediator in CVDs.</p>
TearCare System to Treat Dry Eye Disease
ClinicalTrials.gov study NCT03857919. IPD Sharing: NO. Countries: 1. Publications: 1.
Benefits of Lightweight Ambulatory Oxygen Systems for Individuals With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00325754. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety And Effectiveness Of The TearCare® System In The Treatment Of The Signs And Symptoms Of Dry Eye Disease (SAHARA)
ClinicalTrials.gov study NCT04795752. IPD Sharing: NO. Countries: 1. Publications: 1.
The ACTIVE (Use of the Assurant® Cobalt Iliac Stent System in the Treatment of Iliac Vessel Disease) Study
ClinicalTrials.gov study NCT00753337. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Biomarkers of Lupus Disease: Serial Biomarker Sampling in Patients With Active Systemic Lupus Erythematosus (SLE)
ClinicalTrials.gov study NCT00987831. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy the Medigus SRS Endoscopic Stapling System in Gastroesophageal Reflux Disease (GERD)
ClinicalTrials.gov study NCT00734747. IPD Sharing: Not stated. Countries: 5. Publications: 2.
To Evaluate the Safety and Efficacy of LithoVue Ureteroscope System in Chinese Patients With Urinary Disease
ClinicalTrials.gov study NCT03676972. IPD Sharing: NO. Countries: 1. Publications: 5.
Acthar for the Treatment of Systemic Lupus Erythematosus (SLE) in Patients With a History of Persistently Active Disease
ClinicalTrials.gov study NCT01753401. IPD Sharing: NO. Countries: 1. Publications: 1.
Lymphatic System Health in Alzheimer's Disease
ClinicalTrials.gov study NCT04205539. IPD Sharing: NO. Countries: 1. Publications: 22.
Study of Ruxolitinib in Sclerotic Chronic Graft-Versus-Host Disease After Failure of Systemic Glucocorticoids
ClinicalTrials.gov study NCT03616184. IPD Sharing: NO. Countries: 1. Publications: 1.
Treatment of Parkinson Disease and Multiple System Atrophy Using Intranasal Insulin.
ClinicalTrials.gov study NCT02064166. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing Macr
ClinicalTrials.gov study NCT03311854. IPD Sharing: Not stated. Countries: 5. Publications: 2.
A Pilot Study of the TearCare System in Adults With Dry Eye Disease
ClinicalTrials.gov study NCT03006978. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Test Whether Nintedanib Influences the Components of Birth-control Pills in Women With Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)
ClinicalTrials.gov study NCT03675581. IPD Sharing: UNDECIDED. Countries: 6. Publications: 1.
Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness for Patients With Systemic Sclerosis With Interstitial Lung Disease
ClinicalTrials.gov study NCT01559129. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Study to Evaluate the Effect on Parameters of Systemic Inflammation and Disease Outcomes and Safety of RPH-104 in Subjects With Acute ST-elevation Myocardial Infarction
ClinicalTrials.gov study NCT04463251. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Safety and Tolerability of Pirfenidone in Participants With Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD) (LOTUSS)
ClinicalTrials.gov study NCT01933334. IPD Sharing: Not stated. Countries: 3. Publications: 2.
Cardiac Effects of Rotigotine Transdermal System in Subjects With Advanced-stage Idiopathic Parkinson's Disease
ClinicalTrials.gov study NCT00292227. IPD Sharing: Not stated. Countries: 1. Publications: 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.