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41 results for “tRNA synthetase”
Variant-specific interaction of kinectin 1 with the multi–tRNA synthetase complex regulates ER sheet organization
GEO Series GSE308892. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
Data from: The roles of compensatory evolution and constraint in aminoacyl tRNA synthetase evolution
Mitochondrial protein translation requires interactions between transfer RNAs encoded by the mitochondrial genome (mt-tRNAs) and mitochondrial aminoacyl tRNA synthetase proteins (mt-aaRS) encoded by the nuclear genome. It has been argued that animal mt-tRNAs have higher deleterious substitution rates relative to their nuclear-encoded counterparts, the cytoplasmic tRNAs (cyt-tRNAs). This dynamic predicts elevated rates of compensatory evolution of mt-aaRS that interact with mt-tRNAs, relative to aaRS that interact with cyt-tRNAs (cyt-aaRS). We find that mt-aaRS do evolve at significantly higher rates (exemplified by higher dN and dN/dS) relative to cyt-aaRS, across mammals, birds, and Drosophila. While this pattern supports a model of compensatory evolution, the level at which a gene is expressed is a more general predictor of protein evolutionary rate. We find that gene expression level explains 10-56% of the variance in aaRS dN/dS, and that cyt-aaRS are more highly expressed in addition to having have lower dN/dS values relative to mt-aaRS, consistent with more highly expressed genes being more evolutionarily constrained. Furthermore, we find no evidence of positive selection acting on either class of aaRS protein, as would be expected under a model of compensatory evolution. Nevertheless, the signature of faster mt-aaRS evolution persists in mammalian, but not bird or Drosophila, lineages after controlling for gene expression, suggesting some additional effect of compensatory evolution for mammalian mt-aaRS. We conclude that gene expression is the strongest factor governing differential amino acid substitution rates in proteins interacting with mitochondrial versus cytoplasmic factors, with important differences in mt-aaRS molecular evolution among taxonomic groups.
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress
ClinicalTrials.gov study NCT05514470. IPD Sharing: NO. Countries: 1. Publications: 0.
Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
GEO Series GSE217634. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional responses to glutaminyl tRNA synthetase Gln4p depletion in Saccharomyces cerevisiae
GEO Series GSE126435. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by high throughput sequencing.
Data from: The roles of compensatory evolution and constraint in aminoacyl tRNA synthetase evolution
Open the record for dataset details and reuse information.
Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised tRNA synthetase
GEO Series GSE196846. Danio rerio. 2 samples. Type: Expression profiling by high throughput sequencing.
Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic "integrated stress response"
GEO Series GSE155309. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Regulation of Ex-Translational Activities Is Primary Function of Multi-tRNA Synthetase Complex
GEO Series GSE158212. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing; Other.
Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis
GEO Series GSE217090. Homo sapiens; Toxoplasma gondii RH. 7 samples. Type: Expression profiling by high throughput sequencing.
Growth Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging
GEO Series GSE141389. Bacillus subtilis. 40 samples. Type: Other; Expression profiling by high throughput sequencing.
Seryl-tRNA synthetase promotes translational readthrough via mRNA binding by involving the selenocysteine incorporation machinery
GEO Series GSE230349. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase
GEO Series GSE160584. Mus musculus. 2 samples. Type: Other.
Transcriptome analysis of differentially expressed genes by tryptophanyl-tRNA synthetase 1 in human peripheral blood mononuclear cells
GEO Series GSE243125. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Broad-spectrum tolerance to disinfectant-mediated bacterial killing due to mutation of the PheS aminoacyl tRNA synthetase
GEO Series GSE282610. Escherichia coli K-12. 4 samples. Type: Expression profiling by high throughput sequencing.
Mutations in tRNA synthetases impair translation and activate the integrated stress response in inherited peripheral neuropathie
GEO Series GSE145006. Mus musculus. 167 samples. Type: Expression profiling by high throughput sequencing.
Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus
GEO Series GSE80407. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by array.
Isoleucyl-tRNA synthetase 1 novel mutation promotes deposition of pulmonary surfactant through stabilizing Cathepsin Z [scRNA-seq]
GEO Series GSE250411. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Isoleucyl-tRNA synthetase 1 novel mutation promotes deposition of pulmonary surfactant through stabilizing Cathepsin Z
GEO Series GSE250412. Homo sapiens; Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Inhibitor of prolyl-tRNA synthetase (PRS) to reduce tubulointerstitial nephritis
GEO Series GSE213683. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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