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856 results for “time course”
The process of HDAC11 Assay Development: time-course study
<p>Using Boc-Lys-(TFA)-AMC substrate, a preliminary time-course study was initiated to determine the appropriate HDAC11 concentration and the time to be used for the reaction (which are essential parameters to perform Km calculations later).</p> <p>The updated version2 (v2) has the corrected reaction recipe.</p>
A time-course analysis using Differential Static Light Scattering (DSLS) of purified HTT1-3144 Q23 - 2019/01/28
<p><strong>Project: </strong>Biophysical investigation of purified HTT protein samples</p> <p><strong>Experiment: </strong>A time-course analysis using Differential Static Light Scattering (DSLS) of purified HTT<sup>1-3144</sup>Q23 </p> <p><strong>Date completed:­ </strong>2019/01/28</p> <p><strong>Rationale: </strong>Time and resources in the HD field have been primarily focussed on understanding HTT aggregation looking as caspase cleavage products spanning aa. 1-586 or exon 1 spanning aa. 1-90. However, we know that HTT protein purified in its apo form is able to self-associate into larger oligomeric species and that monomer, dimer and larger species are found following FLAG-affinity chromatography as determined by size-exclusion chromatography (SEC) and SEC-multi-angle light scattering (SEC-MALS). This experiment aimed to begin to investigate how HTT self-associates and aggregates over time in a range of different conditions. </p>
Comparison of Fixed Single Cell RNA-seq Methods to Enable Transcriptome Profiling of Neutrophils in Clinical Samples - Time course data
<p>Monitoring neutrophil gene expression is a powerful tool for understanding disease mechanisms, developing new diagnostics, therapies and optimizing clinical trials. Neutrophils are sensitive to the processing, storage and transportation steps that are involved in clinical sample analysis. This study is the first to evaluate the capabilities of technologies from 10X Genomics, PARSE Biosciences, and HIVE (Honeycomb Biotechnologies) to generate high-quality RNA data from human blood-derived neutrophils. Our comparative analysis shows that all methods produced high quality data, importantly capturing the transcriptomes of neutrophils. 10X FLEX cell populations in particular showed a close concordance with the flow cytometry data. Here, we establish a reliable single-cell RNA sequencing workflow for neutrophils in clinical trials: we offer guidelines on sample collection to preserve RNA quality and demonstrate how each method performs in capturing sensitive cell populations in clinical practice.</p> <p><strong>This dataset includes only the 10X Flex time course data and analysis.</strong></p>
Time Course of Response to Methylphenidate HCl ER Capsules in Children 6 to 12 Years With ADHD in Classroom Setting
ClinicalTrials.gov study NCT01269463. IPD Sharing: YES. Countries: 1. Publications: 1.
Time Course of Circulating Myocardial Biomarkers After a TASH Procedure.
ClinicalTrials.gov study NCT03648736. IPD Sharing: NO. Countries: 1. Publications: 9.
Time Course Adaptations Using Deuterated Creatine (D3Cr) Method
ClinicalTrials.gov study NCT03573583. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study
ClinicalTrials.gov study NCT02005627. IPD Sharing: NO. Countries: 1. Publications: 1.
The time course of acclimation to the stress of triose phosphate use limitation
Open the record for dataset details and reuse information.
Data from: Eco-evolutionary feedbacks predict the time course of rapid life history evolution
Open the record for dataset details and reuse information.
Time Course of Recovery for Performance Attributes and Circulating Markers of Muscle Damage Following a Rugby Union Match in Amateur Athletes
<p>Supplemental file 1 - Raw data associated with article titled "Time Course of Recovery for Performance Attributes and Circulating Markers of Muscle Damage Following a Rugby Union Match in Amateur Athletes" in MDPI's journal <em>Sports</em></p>
Time-course imaging data of nematode embryos
<p>The following repository contains directories of segmented and cropped time-course image data in ome-zarr format, used for training, validation and testing of a classifier generated by training a ResNet-18 CNN to identify stages of nematode embryos. The associated publication can be found <a href="bit.ly/nematode-classifier">here</a>. Please see our <a href="https://github.com/Arcadia-Science/2023-nematode-embryo-classifier">GitHub Repository</a> for further documentation. The following metadata corresponds to each directory:</p><p><strong>Date: Species, Strain, Perturbation</strong></p><p>230719: <i>C. elegans</i>, DQM327, control (wild-type)</p><p>230817: <i>C. elegans</i>, N2, heat shock</p><p>231031: <i>C. elegans</i>, DQM327, control (0M NaCl) and osmotic shock (0.5M NaCl and 0.75M NaCl)</p><p>231012: <i>O. tipulae</i>, CEW1, wild-type</p><p>231013: <i>C. portoensis</i>, EG4788, wild-type</p>
time course gene expression of atrial cardiomyocyte differentiation
<p>atrial cardiomyocyte protocol was similar to that described by Cyganek et al. 2018</p>
Dataset: lhp1 FLC-Venus time course imaging – Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory
<p>The histone modification H3K27me3 plays a central role in Polycomb-mediated epigenetic silencing. H3K27me3 recruits and allosterically activates Polycomb Repressive Complex 2 (PRC2), which adds this modification to nearby histones, providing a read/write mechanism for inheritance through DNA replication. However, for some PRC2 targets, a purely histone-based system for epigenetic inheritance may be insufficient. We address this issue at the Polycomb target Flowering Locus C (FLC) in Arabidopsis thaliana, as a narrow nucleation region of only ~three nucleosomes within FLC mediates epigenetic state switching and subsequent memory over many cell cycles. To explain the memory's unexpected persistence, we introduce a mathematical model incorporating extra protein memory storage elements with positive feedback that persist at the locus through DNA replication, in addition to histone modifications. Our hybrid model explains many features of epigenetic switching/memory at FLC and encapsulates generic mechanisms that may be widely applicable.</p>
Time Course of the Blood Pressure Lowering Effect of Liraglutide Therapy in Type 2 Diabetes
ClinicalTrials.gov study NCT01499108. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy
ClinicalTrials.gov study NCT03410576. IPD Sharing: NO. Countries: 1. Publications: 2.
24-Hour Time Course of Striatal Dopamine D2 Receptor Occupancy of Ziprasidone: A PET Study
ClinicalTrials.gov study NCT00818298. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Magnesium Sulphate on the Time Course of Rocuronium Induced Neuromuscular Block
ClinicalTrials.gov study NCT00405977. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Physical Activity Intervention Flexibility on the Time Course of Changes in Body Composition and Metabolism
ClinicalTrials.gov study NCT02020239. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Concentration-time Course of Plasma and Intracellular Raltegravir in Healthy Volunteers
ClinicalTrials.gov study NCT01027182. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Multiple Oral Doses Of PF-04895162
ClinicalTrials.gov study NCT01691274. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.