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Dataset results
37 results for “toxicity tests”
Data from: All-trans retinoic acid disrupts development in ex vivo cultured fetal rat testes. II: modulation of mono-(2-ethylhexyl) phthalate toxicity
Humans are universally exposed to low levels of phthalate esters (phthalates), which are used to plasticize polyvinyl chloride. Phthalates exert adverse effects on the development of seminiferous cords in the fetal testis through unknown toxicity pathways. To investigate the hypothesis that phthalates alter seminiferous cord development by disrupting retinoic acid signaling in the fetal testis, gestational day 15 fetal rat testes were exposed for 1-3 days to 10-6 M all-trans retinoic acid (ATRA) alone or in combination with 10-6 to 10-4 M mono-(2-ethylhexyl) phthalate (MEHP) in ex vivo culture. As previously reported, exogenous ATRA reduced seminiferous cord number. This effect was attenuated in a concentration-dependent fashion by MEHP co-exposure. ATRA and MEHP-exposed testes were depleted of DDX4-positive germ cells but not Sertoli cells. MEHP alone enhanced the expression of the retinoic acid receptor target Rbp1 and the ovary development-associated genes Wnt4 and Nr0b1, and suppressed expression of the Leydig cell marker, Star, and the germ cell markers, Ddx4 and Pou5f1. In co-exposures, MEHP predominantly enhanced the gene expression effects of ATRA, but the Wnt4 and Nr0b1 concentration-responses were non-linear. Similarly, ATRA increased the number of cells expressing the granulosa cell marker FOXL2 in testis cultures, but this induction was attenuated by addition of MEHP. These results indicate that MEHP can both enhance and inhibit actions of ATRA during fetal testis development and provide evidence that retinoic acid signaling is a target for phthalate toxicity in the fetal testis.
Supplementary material 1 from: Zidar P, Fišer Ž (2022) Avoidance behaviour toxicity tests should account for animal gregariousness: a case study on the terrestrial isopod Porcellio scaber. In: De Smedt P, Taiti S, Sfenthourakis S, Campos-Filho IS (Eds) Facets of terrestrial isopod biology. ZooKeys 1101: 87-108. https://doi.org/10.3897/zookeys.1101.76711
Table S1–S7
Figure 2 in Investigation of protective effects of lithium borate on spermatogenesis and testes histopathology against cadmium-induced acute toxicity in rats
Figure 2. In testicular tissue, control group, normal histological appearance (A), Cd group, severe hyperaemia (arrows) and haemorrhage (stars) in intertubular intervals, severe levels degenerative and necrotic changes in spermatocytes (arrowhead) (B), LTB group, normal histological appearance (C), LTB + Cd group, oedema in intertubular intervals (stars), mild degeneration of spermatocytes (arrows) (D), H&E, Bar: 20 µm.
dataset for paper Toxicity Test of Propolis Product as Protective and Therapeutic Substance for Embryo of Chicken
<p>This data set is free to download </p>
Data from: All-trans retinoic acid disrupts development in ex vivo cultured fetal rat testes. II: modulation of mono-(2-ethylhexyl) phthalate toxicity
Open the record for dataset details and reuse information.
Evaluation of the physiology of medaka for standardized toxicity tests of chemicals
GEO Series GSE15380. Oryzias latipes. 88 samples. Type: Expression profiling by array.
Toxicity Testing in the 21st Century: An Integrated Approach to Genetic Safety Testing using the TGx-DDI Genomic Biomarker and High-Throughput CometChip® [Sequencing]
GEO Series GSE196372. Homo sapiens. 96 samples. Type: Expression profiling by high throughput sequencing.
Mechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing?
GEO Series GSE35697. Rattus norvegicus. 2 samples. Type: Expression profiling by array.
Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing
<p>Data supporting manuscript <strong>Patlewicz G</strong>, Richard AM, Wiliams AJ, Judson RS, Thomas RS. 2022. Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing. Computational Toxicology <em>in press </em>https://doi.org/10.1016/j.comtox.2022.100250</p>
Determination of Assay Cut-Off for the RadTox Test in Prostate Cancer Patients to Predict GI Radiation Toxicity
ClinicalTrials.gov study NCT04580667. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Blood Test to Predict Radiation Response and Toxicity in Patients Undergoing Radiation Therapy
ClinicalTrials.gov study NCT03142425. IPD Sharing: NO. Countries: 1. Publications: 0.
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation, and optimization for histone deacetylase inhibitors
GEO Series GSE71127. Homo sapiens. 85 samples. Type: Expression profiling by array.
Toxicity Testing in the 21st Century: An Integrated Approach to Genetic Safety Testing using the TGx-DDI Genomic Biomarker and High-Throughput CometChip® [NanoString]
GEO Series GSE196369. Homo sapiens. 96 samples. Type: Expression profiling by array.
18794 - Human Photo Toxicity Test
ClinicalTrials.gov study NCT02751372. IPD Sharing: Not stated. Countries: 1. Publications: 0.
High accuracy classification of developmental toxicants by in vitro tests of human neuroepithelial and cardiomyoblast differentiation
GEO Series GSE209962. Homo sapiens. 213 samples. Type: Expression profiling by array.
Toxicity Testing in the 21st Century: An Integrated Approach to Genetic Safety Testing using the TGx-DDI Genomic Biomarker and High-Throughput CometChip®
GEO Series GSE196373. Homo sapiens. 192 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Classification of developmental toxicants in a human iPSC transcriptomics-based test
GEO Series GSE187001. Homo sapiens. 213 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.