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29 results for “toxin resistance”
Data from: The effects of spatial structure, frequency dependence and resistance evolution on the dynamics of toxin-mediated microbial invasions
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HT-SuperSAGE of the gut tissue of a Vip3A-resistant Heliothis virescens F. (Lepidoptera: Noctuidae) strain provides insights into its evolution and toxin adaptation
GEO Series GSE72228. Heliothis virescens. 2 samples. Type: Expression profiling by high throughput sequencing.
CRISPR-Cas9 mutagenesis of A549 cells for variants resistant to the ExoU toxin from Pseudomonas aeruginosa
GEO Series GSE154751. Homo sapiens. 4 samples. Type: Other.
Investigating the role of Osiris genes in Drosophila sechellia larval resistance to a host plant toxin
GEO Series GSE123186. Drosophila sechellia. 6 samples. Type: Expression profiling by high throughput sequencing.
A Noncanonical Intrinsic Terminator in the HicAB Toxin‒Antitoxin Operon Promotes the Transmission of Conjugative Antibiotic Resistance Plasmids
GEO Series GSE284789. Escherichia coli. 3 samples. Type: Expression profiling by high throughput sequencing.
Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study
ClinicalTrials.gov study NCT07236632. IPD Sharing: YES. Countries: 0. Publications: 0.
Toxin mediates sepsis caused by methicillin-resistant Staphylococcus epidermidis
GEO Series GSE85265. Staphylococcus epidermidis ATCC 12228; Chlamydia trachomatis D/UW-3/CX; Chlamydia pneumoniae AR39; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435; Staphylococcus epidermidis; Staphylococcus aureus subsp. aureus MW2; Granulibacter bethesdensis; Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A. 15 samples. Type: Expression profiling by array.
Data from: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
<p>A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in the recurrent evolution of resistance to cardiotonic steroids (CTS) across tetrapods, which occurs via specific amino acid substitutions to the α-subunit family of Na,K-ATPases (ATP1A). After identifying a series of recurrent substitutions at two key sites of ATP1A that are predicted to confer CTS resistance in diverse tetrapods, we then performed protein engineering experiments to test the functional consequences of introducing these substitutions onto divergent species backgrounds. In line with previous results, we find that substitutions at these sites can have substantial background-dependent effects on CTS resistance. Globally, however, these substitutions also have pleiotropic effects that are consistent with additive rather than background-dependent effects. Moreover, the magnitude of a substitution's effect on activity does not depend on the overall extent of ATP1A sequence divergence between species. Our results suggest that epistatic constraints on the evolution of CTS-resistant forms of Na,K-ATPase likely depend on a small number of sites, with little dependence on overall levels of protein divergence. We propose that dependence on a limited number sites may account for the observation of convergent CTS resistance substitutions observed among taxa with highly divergent Na,K-ATPases.</p>
Data from: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.