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467 results for “Trial Data”
Data from: Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial
Objectives: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb. Design: Prospective double-blinded placebo-controlled trial testing for difference in infection rates. Setting: Primary care in regional North Queensland, Australia. Participants: 52 patients undergoing lower limb skin lesion excision. Interventions: 2 g dose of cephalexin 30–60 min before excision. Main outcome measures: Incidence of SSI. Results: Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064). This represented an absolute reduction of 23.21% (95% CI −0.39% to 46.82%), relative reduction of 65.00% (95% CI −12.70% to 89.13%) and number-needed-to-treat of 4.3. Conclusions: Administration of a single 2 g dose of cephalexin 30–60 min before skin lesion excision from the lower limb may produce a reduction in the incidence of infection; however, this study was underpowered to statistically determine this. Trial registration number: ACTRN12611000595910.
Data from: Video education versus face-to-face education on inhaler technique for patients with well-controlled or partly-controlled asthma: a phase IV, open-label, non-inferiority, multicenter, randomized, controlled trial
Background: Education on inhaler technique is critical for effective asthma treatment. However, traditionally used face-to-face education is a time-consuming, costly, and often laborious. The current study evaluated the efficacy of a newly developed video-based inhaler technique education method. Methods: A total of 184 subjects with well-controlled or partly-controlled asthma were enrolled from 12 hospitals in South Korea from 30 November 2015 to 01 June 2016. Subjects were randomly divided into two groups in a 1:1 ratio; a control group that received face-to-face education, and an study group that received video education. All subjects received fluticasone propionate plus salmeterol xinafoate (Fluterol® 250/50 inhalation capsules) for 12 weeks. The primary outcome measure was forced expiratory volume in the 1st second (FEV1) at 12 weeks. The secondary outcome measures were change in FEV1 at 4 weeks, change in asthma control test (ACT) score, and changes in various inhaler technique parameters. These measures were assessed with a non-inferiority margin of 10% between the control group and the study group. Results: FEV1 was significantly improved at 12 weeks in the control group and the study group. After adjustment, FEV1 improvement was not significantly inferior in the study group compared to the control group. The secondary outcome measures, including change in FEV1 at 4 weeks, ACT score, and various parameters pertaining to inhaler technique and satisfaction at 4 and 12 weeks did differ not significantly in the two groups. In subgroup analysis of elderly subjects and subjects with well-controlled asthma, FEV1 was significantly improved at 12 weeks in the study group but not the control group. Conclusion: The newly developed video education technique investigated functioned as a suitable substitute for face-to-face education on inhaler technique (dry powder inhalation capsule) in patients with stable asthma, particularly in elderly patients and patients with well-controlled asthma.
Aggregated Deidentified Participant Data for the Sole Participant Trials
Open the record for dataset details and reuse information.
Data from: Influence of needle-insertion depth on epidural spread and clinical outcomes in caudal epidural injections: a randomized clinical trial
Background: A caudal epidural steroid injection (CESI) is a commonly used method to improve symptoms of lumbosacral pain. We compared the achievement of successful epidurograms and patient-reported clinical outcomes following different needle-insertion depths during CESI. Methods: For the conventional method group, the needle was advanced into the sacral canal. For the alternative method group, the needle was positioned immediately after penetration of the sacrococcygeal ligament. Epidural filling patterns and vascular uptake during fluoroscopy were determined to verify successful epidural injection. Procedural pain scores were investigated immediately after the procedure. Pain scores and patient global impression of symptom change were evaluated at 1-month follow-up. Results: Assessments were completed by 127 patients (conventional method, n=64; alternative method, n=63). The incidence of intravascular injection was significantly lower in the alternative method group than in the conventional method group (3.2% vs 20.3%, P=0.005). Procedural pain during needle insertion was significantly lower in the alternative method group (3.7±1.3 vs 5.3±1.2, P<0.001). Epidural contrast filling patterns were similar in both groups. One-month follow-up pain scores and patient global impression of symptom change were comparable in both groups. Conclusion: Compared with the conventional method, the alternative method for CESI could achieve similar epidural spread and symptom improvement. The alternative technique exhibited clinical benefits of a lower rate of intravascular injection and less procedural pain.
Supplemental data to our study: Minimum inhibitory concentrations of chlorhexidine- and lactic acid-based teat disinfectants: an intervention trial assessing bacterial selection and susceptibility
<p>Supplemental data to our study: Minimum inhibitory concentrations of chlorhexidine- and lactic acid-based teat disinfectants: an intervention trial assessing bacterial selection and susceptibility</p>
RAVLT Trial 1 Raw data
<p>Raw data for RAVLT Trial 1</p>
Replication of the LEAD-2 Diabetes Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT05162183. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the RELY Anticoagulant Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT04593043. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adjunct Collection of Additional Biorepository Data From Patients Enrolled in Diabetic Foot Consortium (DFC) Trials
ClinicalTrials.gov study NCT05092620. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the POET-COPD Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT05083429. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the P04334 Asthma Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT04892758. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the TRANSCEND Antihypertensive Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT04354376. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the ROCKET-AF Anticoagulant Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT04593056. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the DAPA-CKD (Chronic Kidney Disease) Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT04882813. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the VERO Osteoporosis Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT04879420. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors
ClinicalTrials.gov study NCT05982691. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Replication of the ONTARGET Antihypertensive Trial in Healthcare Claims Data
ClinicalTrials.gov study NCT04354350. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Anonymization of Clinical Data From Pseudonymized Databases Collected as Part of Previus Clinical Trials on Multiple Myeloma
ClinicalTrials.gov study NCT07283224. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Collection of Performance Data From the Integrated Sensor and Infusion Set. TRIAL 4
ClinicalTrials.gov study NCT01775059. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
ClinicalTrials.gov study NCT05338697. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.