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429 results for “physiological data”
Data from: Physiological and social consequences of gastrointestinal nematode infection in a nonhuman primate
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Data from: Dense dwarfs versus gelatinous giants: the trade-offs and physiological limits determining the body plan of planktonic filter feeders
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Data from: Predicting the response to simultaneous selection: genetic architecture and physiological constraints
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Data from: Developmental stress can uncouple relationships between physiology and behaviour
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Data from: Patterns of physiological decline due to age and selection in Drosophila melanogaster
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Data from: Laboratory maintenance does not alter ecological and physiological patterns among species: a Drosophila case study
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Data from: Metabolic physiology explains macroevolutionary trends in the melanic colour system across amniotes
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Data from: Physiological tremor reveals how thixotropy adapts skeletal muscle for posture and movement
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Data from: Prey nutritional state drives divergent behavioural and physiological responses to predation risk
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Data from: Using artificial intelligence classification of videos to examine the environmental, evolutionary and physiological constraints on provisioning behavior
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Data from: A novel degree of sex difference in laryngeal physiology of Xenopus muelleri: behavioral and evolutionary implications
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Data from: Changes in the chlorophyll content of grape leaves could provide a physiological index for responses and adaptation to UV-C radiation
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Data from: The physiological costs of prey switching reinforce foraging specialization
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Data from: Adjustable temperature array for characterising ecological and evolutionary effects on thermal physiology
1. To accurately characterise a species' thermal niche and aid in predicting effects of climate change we must not only include information on thermal tolerances and physiological responses to changing temperatures, but also incorporate ecological effects and evolutionary processes that may shape a species' niche. However, quickly and practically collecting data on key factors such as adaptation potential, behaviour, effects of species interactions, plasticity, and thermal tolerances is logistically challenging. 2. We have therefore created an adjustable temperature array (ATA) to assist with experimental ecology and evolution research. ATA's are a row of independent temperature points controlled and set by the user and made from commercially-available parts. This allows the user to create unique thermal landscapes relevant to their study organism(s) and question(s). Further, the option of using an enclosed cage allows the user to answer questions at the individual, population, or community level in the context of changing thermal environments. ATA's are able to be user-set to constant or dynamic temperature regimes and are designed for use on small animals (e.g., fruit flies, beetles, mosquitoes) or plants (e.g., germinating seeds). 3. We have tested and confirmed the accuracy of the ATA to several thermal landscapes that would be useful for experimental ecology and evolution, including: 1) coarse resolution of a broad thermal niche ranging from 12° to 42°C in 2°C intervals (R2= 0.998); 2) fine resolution of a narrow thermal niche ranging from 15° to 32°C in 1°C intervals (R2= 0.997); 3) a pyramid-shaped niche consisting of a gradient from 14° to 30°C in 2°C intervals (R2 = 0.997); and 4) a very narrow thermal niche with replicate thermal resources ranging from 26.5° to 34°C in 1.5°C. intervals (R2= 0.989). 4. The equipment described here is an important tool for thermal niche studies and will aid in gathering information on effects of ecological and evolutionary processes to create a comprehensive picture of species responses to climate change.
Data from: From the cover: three-dimensional (3d) heparg spheroid model with physiologically relevant xenobiotic metabolism competence and hepatocyte functionality for liver toxicity screening.
Effective prediction of human responses to chemical and drug exposure is of critical importance in environmental toxicology research and drug development. While significant progress has been made to address this challenge using invitro liver models, these approaches often fail due to inadequate tissue model functionality. Herein, we describe the development, optimization, and characterization of a novel three-dimensional (3D) spheroid model using differentiated HepaRG cells that achieve and maintain physiologically relevant levels of xenobiotic metabolism (CYP1A2, CYP2B6, and CYP3A4/5). This invitro model maintains a stable phenotype over multiple weeks in both 96- and 384-well formats, supports highly reproducible tissue-like architectures and models pharmacologically- and environmentally important hepatic receptor pathways (ie AhR, CAR, and PXR) analogous to primary human hepatocyte cultures. HepaRG spheroid cultures use 50–100× fewer cells than conventional two dimensional cultures, and enable the identification of metabolically activated toxicants. Spheroid size, time in culture and culture media composition were important factors affecting basal levels of xenobiotic metabolism and liver enzyme inducibility with activators of hepatic receptors AhR, CAR and PXR. Repeated exposure studies showed higher sensitivity than traditional 2D cultures in identifying compounds that cause liver injury and metabolism-dependent toxicity. This platform combines the well-documented impact of 3D culture configuration for improved tissue functionality and longevity with the requisite throughput and repeatability needed for year-over-year toxicology screening.
Data from: Shining new light on mammalian diving physiology using wearable near-infrared spectroscopy
Investigation of marine mammal dive-by-dive blood distribution and oxygenation has been limited by a lack of non-invasive technology for use in freely diving animals. Here, we developed a non-invasive near-infrared spectroscopy (NIRS) device to measure relative changes in blood volume and haemoglobin oxygenation continuously in the brain and blubber of voluntarily diving harbour seals. Our results show that seals routinely exhibit preparatory peripheral vasoconstriction accompanied by increased cerebral blood volume approximately 15 s before submersion. These anticipatory adjustments confirm that blood redistribution in seals is under some degree of cognitive control that precedes the mammalian dive response. Seals also routinely increase cerebral oxygenation at a consistent time during each dive, despite a lack of access to ambient air. We suggest that this frequent and reproducible reoxygenation pattern, without access to ambient air, is underpinned by previously unrecognised changes in cerebral drainage. The ability to track blood volume and oxygenation in different tissues using NIRS will facilitate a more accurate understanding of physiological plasticity in diving animals in an increasingly disturbed and exploited environment.
Computational data on "Proton Affinity and Conformational Integrity in a 24-atom Triazine Macrocycle Across Physiologically-relevant pH"
<p>The archive contains 5 different folders:<br><br>1. mdp_files, that contains all the input files for the minimization, equilibration and molecular dynamics run (in gromacs format);<br>2. topologies, that contains the equilibrated configurations and topology of the 2 systems studied -protonated and deprotonated macrocycles- (in gromacs format);<br>3. trajectories, that contains the coordinates of the macrocycles during the metadynamics calculations and the relevant metadynamics output files (hills file and energy file);<br>4. plumed_input, that contains the input file for the metadynamics calculations.<br>5. gaussian, that contains input and output for the single-point charge calculations.</p>
RESONANCES Database : Experiment no. 2 — Physiological Data
<p><span>This dataset is an output of the RESONANCES neurophysiological-signal-based testing protocol aimed at recognizing and measuring atmospheric emotions. It contains participants’ heart rate (HR) and skin conductance (SCR) data, collected throughout three ranges: 30 seconds in the starting room (baseline feedback), 7 seconds after the first door (changes in physiological arousal while experiencing the corridor’s atmosphere), and 7 seconds after the second door (reactions to the targeted space). Each participant (n = 30) experienced four iterations: amber, blue, bright, and dark light conditions.</span></p> <p><span>The dataset embeds three files:<br>no. 1 dataset summary (.pdf)<br>no. 1 text file (.txt) with the database instructions and data legend to work with Excel datasheets<br>no. 1 zipped database (.zip) including 30 participant subfolders, each made of twelve files (.xlsx) with HR and SC data.<br></span></p>
Collection and Analyses of Physiological, Physical, and Molecular Data From a Diverse Population
ClinicalTrials.gov study NCT06381232. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Physiological and Environmental Data in a Remote Setting to Predict Exacerbation Events in Patients With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT06118632. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.