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Dl-3-n-butylphthalide alleviates cognitive impairment induced by chronic cerebral hypoperfusion via inhibiting the mitochondrial permeability transition pore opening and excessive mitophagy
<p> This is a zip folder including the original, uncropped and unadjusted images of IF and TEM.</p>
The topographic signature of temperature controlled rheological transitions in accretionary prism
<p>Supplement model movies</p>
FIGURE 14 in The genus Pseudocleobis Pocock, 1900 (Solifugae: Ammotrechidae) in transitional Patagonia-Monte deserts, with descriptions of two new species
FIGURE 14. Pseudocleobis profanus sp. nov., male. A–C. Right pedipalp. A. Slit sensilla. B. Tapered seta tip. C. Clubbed seta tip. D–F. Right leg I. D. Apex of telotarsus, apical seta in light blue. E. Detail of apical seta. F. Clubbed seta tip. G–I. Right malleoli. G. Frontal view. H. Surface detail. I. Detail of projections. J–L. Sternite microseta. J. Right pair of microseta on sternite IV, detail of each microseta tip on yellow circles. K. Left pair of microseta on sternite IV. L. Right microseta on sternite V. Scale bars: 300 nm (both details in J), 400 nm (B), 2 μm (F, H–I), 3 μm (C), 4 μm (K–L), 6 μm (A, J), 20 μm (E), 60 μm (D), 200 μm (G).
Virtual Reality in transit: how acceptable is VR use on public transport?
<p>These are raw data sets from two surveys investigating VR acceptance on different modes of public transport (N1=60, N2=108) for our published paper entitled "Virtual Reality in transit: how acceptable is VR use on public transport?". DOI: https://doi.org/10.1109/VRW52623.2021.00098.</p> <p> </p>
Figure 8. A in Redescription of the hermit crab Diogenes pugilator (Decapoda: Anomura) reveals the existence of a species complex in the Atlanto-Mediterranean transition zone, resulting in the resurrection of D. curvimanus and the description of a new species
Figure 8. A, maximum likelihood phylogenetic tree based on the concatenated mitochondrial data (COI + 16S) using 1000 nonparametric bootstrap replicates. Numbers on the branches represent ML bootstrap values; only bootstrap values> 70 (ML) are included. The species Dardanus arrosor and Paguristes eremita are included as outgroups. Groups recovered from the ABGD analysis (G.1–G.9) are also included. B, histogram of genetic distances (JC69 Jukes–Cantor) showing the barcoding gap for the COI gene.
Isolated limb perfusion and immunotherapy in the treatment of in-transit melanoma metastases
<p><strong><span>Background:</span></strong><span> Isolated limb hyperthermic-antiblastic perfusion (ILP) was the most effective local treatment for advanced in-transit melanoma, but the advent of modern effective immunotherapy (IT) such as immune checkpoint inhibitors has changed the treatment landscape. <strong>Methods:</strong> This study evaluated the role of the association between ILP and IT in the treatment of locally advanced unresectable melanoma, in particularly in relation to modern systemic therapies. We analyzed 187 consecutive patients who were treated with ILP (melphalan or melphalan associated with TNF-alpha) for advanced melanoma at the Veneto Institute of Oncology of Padua (Italy) and the Padua University Hospital (Italy) between June 1989 and September 2021. Overall survival (OS), disease specific survival (DSS), local disease-free survival (local DFS) and distant disease-free survival (distant DFS) were evaluated. Local toxicity was classified according to the Wieberdink scale and surgical complications according to the Clavien-Dindo classification. Response to locoregional therapy was evaluated during follow-up according to RECIST 1.1 criteria (Response Evaluation Criteria in Solid Tumor). <strong>Results</strong>: 99 patients were treated with ILP and 88 with IT+ILP. Overall response rate was 67% in both groups. At 36 months, OS was 43% in ILP group and 61% in ILP+IT group (p=0.02); DSS was 43% in ILP group and 64% in ILP+IT group (p=0.02); local DFS was 37% in ILP group and 53% in ILP+IT group (p=0.04); distant DFS was 33% in ILP group and 35% in ILP+IT group (p=0.40). Adjusting for age and lymph node involvement, receiving ILP+IT was associated with improved OS (p=0.01) and DSS (p=0.007) but not local DFS (p=0.13) and distant DFS (p=0.21). <strong>Conclusions:</strong> Our findings confirm the synergy between ILP and IT. ILP remains a valuable loco-regional treatment option in the era of effective systemic treatments. Further studies are needed to establish the optimal combination of loco-regional and systemic treatments, and address the best timing of this combination to obtain the highest local response rate</span>.</p>
Nanoscale brittle-to-ductile transition of the C15 CaAl2 Laves phase
Open the record for dataset details and reuse information.
Fig. 5 in Strong phylogenetic constraint on transition metal incorporation in the mandibles of the hyper-diverse Hymenoptera (Insecta)
Fig. 5 Phylogenetic tree mapping the ranked Mn % for each taxon analyzed in this study. Mn was ranked as 0 = <0.1 wt%; 1 = 0.1– 1.0 wt%
Fig. 3 in Strong phylogenetic constraint on transition metal incorporation in the mandibles of the hyper-diverse Hymenoptera (Insecta)
Fig. 3 Phylogenetic tree mapping the larval feeding resource (LFR) (0 = plant, 1 = animal (at least partially)) for each taxon analyzed in this study. The circle with a picture of a herbivorous larva (the bee Andrena agilissima (Andrenidae), feeding on a pollen ball) and of a carnivorous larva (the apoid wasp Sceliphron spirifex (Sphecidae), feeding on spiders) mark the ancestral state for Hymenoptera and for Apocrita, respectively. The histogram in the lower part of the figure shows the distribution of cases for a given rank of Zn, for species with either LFR type
FIGURE 21 in The integration processes of the distributional patterns in the Mexican Transition Zone: Phyletic, paleogeographic and ecological factors of a case study
FIGURE 21. Distribution of the O. cyanellus species line, which hypothetically represents oldest stage of evolution of the O. chevrolati species group.
FIGURE 22 in The integration processes of the distributional patterns in the Mexican Transition Zone: Phyletic, paleogeographic and ecological factors of a case study
FIGURE 22. Comparison of the distribution areas of the O. hippopotamus and O. chevrolati species lines.
FIGURE 9 in The integration processes of the distributional patterns in the Mexican Transition Zone: Phyletic, paleogeographic and ecological factors of a case study
FIGURE 9. Main orographic formations of Mexico. Original map prepared by Violeta Halffter and used on many occasions in the biogeographic studies of the Mexican Transition Zone. I, Sierra Madre Occidental; II, Sierra Madre Oriental; III, Mexican Plateau; IV, Trans-Mexican Volcanic Belt; V, Balsas Basin; VI, Sierra Madre del Sur; VII, Sierra Madre de Chiapas; VIII, Chiapas Highlands; IX, Guatemalan Plateau; X, Central American Nucleous.
GCAM Reference Scenario All Land Transitions
Open the record for dataset details and reuse information.
Fig. 4 in Diversity and biogeographical makeup of the dung beetle communities inhabiting two mountains in the Mexican Transition Zone
Fig. 4 Turnover (open circles) of genera and species between pairs of contiguous elevations along each elevation gradient. The number of genera and species lost (black bars) and gained (gray bars) for each pair was compared
Fig. 5 in Diversity and biogeographical makeup of the dung beetle communities inhabiting two mountains in the Mexican Transition Zone
Fig. 5 Changes in the proportion of individuals belonging to species with different biogeographical distribution patterns (sensu Halffter 1987). NEA Nearctic; PMM Montane Paleoamerican; PAT Tropical Paleoamerican; MAM Montane Mesoamerican; NTT Typical Neotropical
Fig. 3 in Diversity and biogeographical makeup of the dung beetle communities inhabiting two mountains in the Mexican Transition Zone
Fig. 3 Principal coordinates graph from the permutational multivariate analysis of variance (PERMANOVA) for Los Tuxtlas and La Chinantla. For both mountains the box and whisker plot shows
Fig. 1 in Diversity and biogeographical makeup of the dung beetle communities inhabiting two mountains in the Mexican Transition Zone
Fig. 1 Location of the different elevations studied in the Mexican Transition Zone. The black dots indicate the sampling stations
FIGURE 7 in Species richness, geographic distribution and endemism of Pinguicula (Lentibulariaceae) in the Mexican Transition Zone
FIGURE 7. Species richness of Pinguicula by grid cell. A, D, G) Species richness distribution; B, E, H) weighted endemism; C, F, I) corrected weighted endemism. A, B, C) Cells size of 0.33° × 0.33°; D, E, F) cells size of 0.54° × 0.54°; G, H, I) cells size of 1° × 1°.
FIGURE 1 in Species richness, geographic distribution and endemism of Pinguicula (Lentibulariaceae) in the Mexican Transition Zone
FIGURE 1. Floral representation of Pinguicula. A) P. crenatiloba; B) P. nivalis; C) P. gracilis; D) P. pygmaea; E) P. parvifolia; F) P. gypsicola; G) P. laueana; H) P. hemiepiphytica; I) P. ehlersieae; J) P. crassifolia; K) P. lilacina, L) P. heterophylla; M) P. kondoi; N) P. rotundiflora; O) P. takaki; P–S) P. moranensis; T) P. cyclosecta; U) P. esseriana; V) P. zamudioana; W) P. oblongiloba; X) P. michoacana. A–C) Subgenus Temnoceras; D–E, K–O, T) Subgenus Isoloba; F–J, P–S, U–X) Subgenus Pinguicula. A–G, I–X) J. López; H) G. Gónzález.
FIG. 1 in Marine Habitat Transitions and Body-Shape Evolution in Lizardfishes and Their Allies (Aulopiformes)
FIG. 1. Illustrations of aulopiform biodiversity with associated habitats. (A) Aulopidae; (B) Synodontidae: Harpadontinae; (C) Synodontidae: Synodontinae; (D) Paraulopidae; (E) Chlorophthalmidae; (F) Ipnopidae; (G) Evermannellidae; (H) Lestidiidae; (I) Giganturidae; (J) Alepisauridae: AnotopteruS; (K) Alepisauridae: AlepiSauruS.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.