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797 results for “Cigarettes”
Varied effects of tobacco smoke and e-cigarette vapor suggest that nicotine does not affect endothelium-dependent relaxation and nitric oxide signaling
<p>Chronic smoking causes dysfunction of vascular endothelial cells, evident as a reduction of flow-mediated dilation in smokers, but the role of nicotine is still controversial. Given the increasing use of e-cigarettes and other nicotine products, it appears essential to clarify this issue. We studied extracts from cigarette smoke (CSE) and vapor from e-cigarettes (EVE) and heated tobacco (HTE) for their effects on vascular relaxation, endothelial nitric oxide signaling, and the activity of soluble guanylyl cyclase. The average nicotine concentrations of CSE, EVE, and HTE were 164, 800, and 85 µM, respectively. At a dilution of 1:3, CSE almost entirely inhibited the relaxation of rat aortas and porcine coronary arteries to acetylcholine and bradykinin, respectively, while undiluted EVE, with a 15-fold higher nicotine concentration, had no significant effect. With about 50% inhibition at 1:2 dilution, the effect of HTE was between CSE and EVE. Neither extract affected endothelium-independent relaxation to an NO donor. At the dilutions tested, CSE was not toxic to cultured endothelial cells but, in contrast to EVE, impaired NO signaling and inhibited NO stimulation of soluble guanylyl cyclase. Our results demonstrate that nicotine does not mediate the impaired endothelium-dependent vascular relaxation caused by smoking.</p>
Role of an E-cigarette on Smoking Displacement in Smokers With Schizophrenia
ClinicalTrials.gov study NCT03075202. IPD Sharing: NO. Countries: 1. Publications: 0.
Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO)
ClinicalTrials.gov study NCT06091826. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 1
ClinicalTrials.gov study NCT05958979. IPD Sharing: NO. Countries: 1. Publications: 0.
Salt-Based E-cigarette
ClinicalTrials.gov study NCT04238832. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Cigarette Reduction Using the Quitbit Digital Lighter and Mobile Application for Smoking Cessation: a Randomized Controlled Trial
ClinicalTrials.gov study NCT02515500. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder
ClinicalTrials.gov study NCT02990455. IPD Sharing: NO. Countries: 1. Publications: 0.
Alcohol and Cigarette Craving During Oxytocin Treatment
ClinicalTrials.gov study NCT04071119. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse
ClinicalTrials.gov study NCT07223840. IPD Sharing: YES. Countries: 3. Publications: 0.
CSD170302: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes
ClinicalTrials.gov study NCT03233997. IPD Sharing: NO. Countries: 1. Publications: 0.
Arsenic Methylation Enzymes, Cigarette Metabolites, DNA Repair Enzymes, Inflammatory Factors and Urothelial Carcinoma
ClinicalTrials.gov study NCT00854464. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sensorimotor Replacement With Electronic and De-nicotinised Cigarettes
ClinicalTrials.gov study NCT01414998. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes
ClinicalTrials.gov study NCT05610514. IPD Sharing: NO. Countries: 1. Publications: 0.
Arterial Inflammation and E-Cigarettes
ClinicalTrials.gov study NCT02734888. IPD Sharing: Not stated. Countries: 1. Publications: 0.
E-cigarettes, Nicotine Inhaler, and Blood Vessel Function
ClinicalTrials.gov study NCT03072628. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effects of Electronic Cigarette and Traditional Cigarette
ClinicalTrials.gov study NCT07131891. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia
ClinicalTrials.gov study NCT06374290. IPD Sharing: NO. Countries: 1. Publications: 0.
Clinical Alternatives for Reducing Harm Using E-cigarettes
ClinicalTrials.gov study NCT07039292. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes
ClinicalTrials.gov study NCT02185898. IPD Sharing: NO. Countries: 1. Publications: 0.
The Impact of Chronic E-Cigarette Usage on Microvascular Health
ClinicalTrials.gov study NCT06860698. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.