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436
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ShareScore release 0.9.0
Dataset results
436 results for “Longevity”
Lysosomes signal through the epigenome to regulate longevity across generations [II]
GEO Series GSE290404. Caenorhabditis elegans. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gut microbiota from old mice confers neurogenic and pro-longevity signatures in young germ-free mice
GEO Series GSE130026. Mus musculus. 18 samples. Type: Expression profiling by array.
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: telomerase-deficient vs PGC1aOE)
GEO Series GSE135404. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of sphingosine metabolism suppresses ferroptosis and rejuvenates aged hematopoietic stem cells to promote cognition and longevity [Low input RNA-seq]
GEO Series GSE287181. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
A Surveillance Pathway Senses Leaked Mitochondrial DNA to Activate UPRmt and Promote Longevity
GEO Series GSE316187. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Global profiling of gene expression in mouse astrocyte in response to the potential longevity determinant miR-29
GEO Series GSE27035. Mus musculus. 6 samples. Type: Expression profiling by array.
Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity.
GEO Series GSE276572. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dietary restriction regulates microRNAs in longevity regulons
GEO Series GSE134925. Caenorhabditis elegans. 13 samples. Type: Non-coding RNA profiling by high throughput sequencing.
How can ant queens live so long? Genes of multiple longevity pathways change expression with age in the ant Temnothorax rugatulus
GEO Series GSE111415. Temnothorax rugatulus. 32 samples. Type: Expression profiling by high throughput sequencing.
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
GEO Series GSE127917. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of sphingosine metabolism suppresses ferroptosis and rejuvenates aged hematopoietic stem cells to promote cognition and longevity [CUT&TAG]
GEO Series GSE287103. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptomic and metabolomic regulation of temperature-dependent longevity in Drosophila melanogaster
GEO Series GSE229837. Drosophila melanogaster. 23 samples. Type: Expression profiling by high throughput sequencing.
Unique sequence features define epigenetic longevity of inflammatory memory
GEO Series GSE300050. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Inhibition of sphingosine metabolism suppresses ferroptosis and rejuvenates aged hematopoietic stem cells to promote cognition and longevity [RNA-seq]
GEO Series GSE287104. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process
GEO Series GSE168068. Mus musculus. 102 samples. Type: Expression profiling by high throughput sequencing.
Identification of DAF-16/FoxO targets associated with longevity
GEO Series GSE111338. Caenorhabditis elegans. 50 samples. Type: Expression profiling by high throughput sequencing.
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: WT vs PKI)
GEO Series GSE136770. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Ellagic Acid Enhances Longevity and Healthspan in Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway
GEO Series GSE295741. Caenorhabditis elegans. 2 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article: "BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice"
<p>Long-living individuals (LLIs) escape age-related cardiovascular complications until the very last stage of life. Previous studies have<br>shown that a Longevity-Associated Variant (LAV) of the BPI Fold Containing Family B Member 4 (BPIFB4) gene correlates with an<br>extraordinarily prolonged life span. Moreover, delivery of the LAV-BPIFB4 gene exerted therapeutic action in murine models of<br>atherosclerosis, limb ischemia, diabetic cardiomyopathy, and aging. We hypothesize that downregulation of BPIFB4 expression<br>marks the severity of coronary artery disease (CAD) in human subjects, and supplementation of the LAV-BPIFB4 protects the heart<br>from ischemia. In an elderly cohort with acute myocardial infarction (MI), patients with three-vessel CAD were characterized by<br>lower levels of the natural logarithm (Ln) of peripheral blood BPIFB4 (p = 0.0077). The inverse association between Ln BPIFB4 and<br>three-vessel CAD was confirmed by logistic regression adjusting for confounders (Odds Ratio = 0.81, p = 0.0054). Moreover, in<br>infarcted mice, a single administration of LAV-BPIFB4 rescued cardiac function and vascularization. In vitro studies showed that LAVBPIFB4<br>protein supplementation exerted chronotropic and inotropic actions on induced pluripotent stem cell (iPSC)-derived<br>cardiomyocytes. In addition, LAV-BPIFB4 inhibited the pro-fibrotic phenotype in human cardiac fibroblasts. These findings provide a<br>strong rationale and proof of concept evidence for treating CAD with the longevity BPIFB4 gene/protein.</p>
Figure 1 in Polygyny, oviposition, life cycle and longevity of the three subspecies of leaf-cutting ants, Acromyrmex subterraneus (Hymenoptera: Formicidae)
Figure 1. Mean development time (days) in three Acromyrmex subspecies.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.