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818 results for “atrophy”
Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy
GEO Series GSE216408. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Distinct microglia subsets are associated with α-synucleinopathy in multiple system atrophy
GEO Series GSE209944. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Mechanism of Mitochondrial Dysfunction in Spinal and Bulbar Muscular Atrophy
GEO Series GSE140018. Homo sapiens. 31 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The growth factor FGF21 maintains neuromuscular junction through histone deacetylase HDAC4 in denervation-induced skeletal muscle atrophy
GEO Series GSE303861. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Data from: Effects of Lewy body disease and Alzheimer's disease on brain atrophy and cognitive dysfunction
Objectives: We investigated the independent and interaction effects of Alzheimer's disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy. Methods: We consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-Florbetaben PET and 18F-FP-CIT-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment (MCI) and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models. Results: Compared to the controls, pure patients with ADCI group and pure LBCI group had focused cortical thinning in the bilateral entorhinal/right anterior temporal cortices and bilateral anteromedial temporal/basal frontal cortices, respectively, while the mixed disease group had additional cortical thinning in the widespread association cortices. The independent effects of ADCI and LBCI on regional cortical thinning overlapped in the widespread association cortices, especially at the bilateral temporo-parietal junction and parietal cortices. ADCI and LBCI had independent detrimental effects on the copying item of the Rey-Osterrieth Complex Figure Test. Conclusions: Concomitant ADCI and LBCI are associated with the accentuation of neurodegeneration to widespread association cortices, and both diseases contribute to visuospatial dysfunction.
A Clinical Trial to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin
ClinicalTrials.gov study NCT02392130. IPD Sharing: NO. Countries: 1. Publications: 0.
Two Different Treatment Modalities in Patients With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT06178653. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of Brain Atrophy Rates, Cognition, and Patient-Reported Outcomes in MS Patients Using Long-term Fingolimod and Glatiramer Acetate
ClinicalTrials.gov study NCT02307877. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients
ClinicalTrials.gov study NCT01064505. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT05808764. IPD Sharing: YES. Countries: 8. Publications: 0.
Study to Evaluate Efficacy of Vagitocin in Postmenopausal Women With Vulvovaginal Atrophy Symptoms
ClinicalTrials.gov study NCT04629885. IPD Sharing: NO. Countries: 1. Publications: 0.
Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment
ClinicalTrials.gov study NCT06965816. IPD Sharing: NO. Countries: 1. Publications: 0.
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
ClinicalTrials.gov study NCT06607913. IPD Sharing: NO. Countries: 1. Publications: 0.
A Placebo-controlled Study of Clenbuterol in Spinal and Bulbar Muscular Atrophy
ClinicalTrials.gov study NCT06169046. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Phase 1/2 Study to Evaluate the Safety and Efficacy of Intravitreal Administration of BS01 in Patients With Geographic Atrophy Secondary to Dry AMD
ClinicalTrials.gov study NCT07158775. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy S
ClinicalTrials.gov study NCT06161584. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Does Long-Term Natalizumab (NTZ) Therapy Normalize Brain Atrophy Rates and Quality of Life (QOL) in Relapsing Remitting Multiple Sclerosis (RRMS)?
ClinicalTrials.gov study NCT02588053. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Longitudinal Study of Brain Atrophy in MS Patients Over 5 Years
ClinicalTrials.gov study NCT01847287. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Long-Term Analysis of DImethyl Fumarate, to Slow the Growth of Areas of Geographic Atrophy
ClinicalTrials.gov study NCT04292080. IPD Sharing: NO. Countries: 1. Publications: 0.
A Phase I/III Clinical Study to Evaluate NouvNeu001 Injection for Multiple System Atrophy
ClinicalTrials.gov study NCT07289477. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.