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5,016
datasets available to search
ShareScore release 0.9.0
Dataset results
5,016 results for “THERAPEUTICS”
Imipramine Blue: A potent therapeutic regimen that suppresses breast cancer growth and metastasis
GEO Series GSE72363. Homo sapiens. 4 samples. Type: Expression profiling by array.
Rhinovirus-induced human lung tissue responses mimic respiratory disease signatures allowing evaluation of therapeutics
GEO Series GSE137905. Homo sapiens. 70 samples. Type: Expression profiling by array.
De novo lipogenesis represents a therapeutic target in Kras mutant NSCLC
GEO Series GSE113717. Mus musculus. 8 samples. Type: Expression profiling by array.
Therapeutic reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice
GEO Series GSE277258. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Adult High Grade B-cell Lymphoma with Burkitt Lymphoma Signature: Genomic features and Potential Therapeutic Targets
GEO Series GSE168422. Homo sapiens. 112 samples. Type: Expression profiling by array.
Microenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Therapeutic Opportunities [DMS273 SCLC cell lines]
GEO Series GSE267560. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.
GEO Series GSE280700. Macaca mulatta; Homo sapiens; Rattus; Mus musculus. 114 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array.
Microarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
GEO Series GSE48433. Homo sapiens. 823 samples. Type: Expression profiling by array.
The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer [H3K4me1 CUT&RUN]
GEO Series GSE308946. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics (RNA-Seq).
GEO Series GSE198054. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Multiscale Drug Screening for Cardiac Fibrosis Identifies MD2 as a Therapeutic Target
GEO Series GSE276566. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PDX for Childhood Cancer Therapeutics
PCAT stores information of 324 PDX models spanning all major cancer types seen in children, including some very rare subtypes.
Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal childhood cancer. Here, we performed a chemical screen in patient-derived DIPG cell cultures along with RNAseq expression analysis and integrated computational modeling to identify potentially effective therapeutic strategies. Panobinostat, among the more promising agents identified, demonstrated efficacy in pontine orthotopic xenograft models of both H3K27M and histone WT DIPG. These data suggest the potential utility of specific drug combinations and provides evidence of in vivo treatment efficacy of the multi-histone deacetylase inhibitor panobinostat.
Therapeutic targeting of GCB- and ABC-DLBCLs by rationally designed BCL6 inhibitors
GEO Series GSE79888. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
GEO Series GSE173083. synthetic construct; Homo sapiens. 70 samples. Type: Other.
Therapeutic Potential of NRF2 activating drug RTA-408 in suppressing T-cell effector responses and inflammatory bowel disease
GEO Series GSE277154. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [Cell lines shCTL shMFN2]
GEO Series GSE222165. Homo sapiens. 12 samples. Type: Expression profiling by array.
Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signalling identifies therapeutic targets for Colorectal Cancer
GEO Series GSE156083. Homo sapiens. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
CXCL8/CXCR2 signaling is Enriched in Fibrotic Myeloproliferative Neoplasms and is Vulnerable to Therapeutic Inhibition [ATAC-Seq]
GEO Series GSE189978. Homo sapiens. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Multi-cohort effectiveness of Gallium-68-PSMA PET/CT and pelvic 3Tesla multi-parametric magnetic resonance imaging in the diagnostic and therapeutic work-up of prostate cancer (MoH RF-2016-02364230)
<p>The project "<strong>Multi-cohort effectiveness of Gallium-68-PSMA PET/CT and pelvic 3Tesla multi-parametric magnetic resonance imaging in the diagnostic and therapeutic work-up of prostate cancer</strong>" is funded by Italian Ministry of Health (project code: <strong>RF-2016-02364230</strong>)</p><p> </p><p>Based on preliminary data, the project hypothesis was that diagnostic accuracy of 68Ga-PSMA PET/CT is comparable to that of mp-3TMRI in pts with pCa. If that is the case, the use of 68Ga-PSMA PET/CT will lead to shorter waiting lists, faster scanning time and lower costs compared to mp-3TMRI. The 1st goal of this project is to guide or replace invasive procedures with a non invasive approach such as mp-3TMRI or 68Ga-PSMA PET/CT. The secondary aim is a comparative analysis of the 2 techniques. </p><p><strong>Specific Aim 1:</strong></p><p>Characterize the incremental benefit of pelvic mp-MRI and 68Ga-PSMA PET/CT in: guiding TRUS-B, to identify clinicallysignificant PCa in pts who are negative at first-round TRUS-B and/or are undergoing AS.</p><p>Stage accuracy of pelvic mp-MRI and 68Ga PSMA PET/CT during the pre-surgical work-up of high-risk PCa pts and PCa pts who are candidates for nerve-sparing surgery.</p><p>The secondary aim is a comparative analysis of the 2 techniques.</p><p><strong>Specific Aim 2:</strong></p><p>Evaluate the accurancy of 68Ga-PSMA PET/CT (i.e. Sensitivity, SE; specificity, SP) in detecting sites of biochemical PCa recurrence compared to routinely-used diagnostic tools (TRUS-B, bone scan, diagnostic CT, MRI and 18F-FCH PET/CT).</p><p>The secondary objectives are SE for different PSA values and SE for different Gleason score.</p><p><strong>Specific Aim 3:</strong></p><p>Evaluate the efficacy in terms of Disease Control Rate (DCR) and the safety of 2 different administration schedules of 177Lu-PSMA in a cohort (C) of metastatic CRPC pts previously treated with standard therapy.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.