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Fig. 5 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 5. Chemical structures of compounds 118–137.
Fig. 8 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 8. Chemical structures of compounds 172–177.
Fig. 10 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 10. Chemical structures of compounds 205–214.
Fig. 1 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 1. Chemical structures of compounds 1-37.
Fig. 7 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 7. Chemical structures of compounds 155–171.
Fig. 4 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 4. Chemical structures of compounds 116–117.
Fig. 12 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 12. Chemical structures of compounds 225–281.
Fig. 6 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 6. Chemical structures of compounds 143–153.
Fig. 9 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 9. Chemical structures of compounds 178–204.
Fig. 3 in Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis
Fig. 3. Chemical structures of compounds 45–115.
Enigmas no longer: using Ultraconserved Elements to place several unusual hawk taxa and address the non-monophyly of the genus Accipiter (Accipitriformes: Accipitridae)
<p>Alignment and tree data associated with the paper:<strong> </strong><span>Enigmas no longer: using Ultraconserved Elements to place several unusual hawk taxa and address the non-monophyly of the genus <em>Accipiter </em>(Accipitriformes: Accipitridae)</span></p>
Figure 1 from: Kadiyska T, Cherneva R, Cherneva Z, Marchev S, Madzharova D, Tourtourikov I, Mitev V (2024) Laboratory and genetic predictors for severe COVID-19 infection. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e120638
Figure 1 The OAS–RNase L pathway and the NLRP3 inflammasome activation. DsRNAs and IFN signaling activate the OAS gene. OAS1 induces the synthesis of the second messenger 2–5A from ATP. 2–5A then binds and transform the RNase L monomer to its active dimer formation. The active RNase L degrades viral RNA, thus inhibiting virus replication. Cleaved RNA, through DHX33 (DEAH-box helicase 33), which binds to cytosolic RNAs and interacts with MAVS (Mitochondrial Antiviral Signaling protein), can activate NLRP3 inflammasome. In most cases, this stimulates the normal anti-viral response, but theoretically, further stimulation of the already hyperactivated NLRP3 inflammasome would intensify the CS.
Several case studies for the DrugFlow paper
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MODERN INNOVATIVE METHODS FOR TREATING SEVERE HAND INJURIES
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raw data - Comparison of High-Flow Nasal Cannula Oxygen and Conventional Oxygen Therapy in a Rat Model of Severe Carbon Monoxide Poisoning
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Severity Index Data
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Data from: Linking radial growth patterns and moderate-severity disturbance dynamics in boreal old-growth forests driven by recurrent insect outbreaks: a tale of opportunities, successes, and failures
<p>In boreal landscapes, emphasis is currently placed on close-to-nature management strategies, which aim to maintain the biodiversity and ecosystem services related to old-growth forests. The success of these strategies, however, depends on an accurate understanding of the dynamics within these forests. This study aims to reconstruct the disturbance and post-disturbance dynamics in boreal old-growth forests that are driven by recurrent moderate-severity disturbances. We studied eight old-growth forests in Québec, Canada, that has recorded recurrent and moderate to severe spruce budworm (Choristoneura fumiferana [Clem.]) outbreaks over the 20th century. To reconstruct the disturbance history and the post-disturbance dynamics of the study sites, we used dendrochronological data and k-means clustering to identify growth releases and growth patterns in the studied trees. We identified nine growth patterns; these patterns represented trees differing in age, size, and canopy layer, and indicated different tree histories. Spruce budworm outbreaks caused recurrent moderate-severity disturbances within the study sites. The canopy gaps created by these disturbances were filled mainly by understorey trees, which responded by single and significant increases in radial growth and height. In contrast, overstorey trees had little influence on gap filling; thus, trees were mostly from the dominant and codominant canopy layers. Our study underlines the resistance of boreal old-growth forests to recurrent and moderate-severity disturbances, as understorey trees can rapidly fill the resulting gaps. However, trees that are unable to attain the canopy following the disturbance then tend to remain in the lower canopy layers. Therefore, reaching the canopy represents a once-in-a-lifetime opportunity, where success or failure depends on a relatively short window of time. This gap-filling dynamic produces, however, a vertical structure that is often similar to the expected structure in even-aged forests. Our results highlight the efficacy of identifying tree growth patterns to reconstruct stand disturbance dynamics and contribute to developing closer to nature forest management strategies.</p>
Assessment of plasma testosterone, estradiol, and progesterone levels in Vietnam female patients with moderate to severe acne vulgaris
<p><strong>Introduction</strong>: Acne is a chronic inflammatory disorder of the pilosebaceous unit with differential pathogenesis. To elucidate the roles of hormones in acne pathogenesis, we conducted a study to evaluate the plasma testosterone, estradiol, and progesterone levels in women with acne vulgaris.</p> <p><strong>Methods</strong>: We conducted a cross-sectional descriptive study, and 1<span>40</span> women with acne vulgaris were examined; their plasma estradiol, progesterone, and testosterone were analyzed by chemiluminescence technique and compared with the healthy control group.</p> <p><span><strong>Results</strong>:</span><span> </span>Increased plasma hormone levels in women with acne vulgaris accounted for 33.57%, and hyperandrogenism accounted for 20.71% of cases. We found significant differences in testosterone levels (mean value, 56.92 ± 27.64ng/dL, 60.71± 25.85ng/dL versus 38.35 ± 10.09ng/dL, p<0.05), respectively, in the moderate to severe acne group and the control group. However, the estradiol level of the moderate and severe acne groups (325.12 ± 91.79 and 305.26 ± 83.01pmol/l) was lower than the control group (368.6 ± 58.34pmol/l), with p-value under 0.05. No statistically significant differences were found for progesterone levels. </p> <p><span><strong>Conclusion</strong>:</span><span> Our study showed that female patients with moderate to severe acne vulgaris had abnormalities in plasma testosterone and estradiol levels. These abnormalities might be part roles in the pathogenesis of acne vulgaris, even when the mean levels were in the normal range. Female patients suffering from premenstrual acne flares might be examined for plasma testosterone levels.</span></p>
Data from: Genotyping-in-Thousands by sequencing of archival fish scales reveals maintenance of genetic variation following a severe demographic contraction in kokanee salmon
<p>Historical DNA analysis of archival samples has added new dimensions to population genetic studies, enabling spatiotemporal approaches for reconstructing population histories and informing conservation management. Here we tested the efficacy of Genotyping-in-Thousands by sequencing (GT-seq) for collecting targeted single nucleotide polymorphism (SNP) genotypic data from archival scale samples, and demonstrate its application to a study of kokanee salmon (<i>Oncorhynchus nerka</i>) in Kluane National Park and Reserve (KNPR; Yukon, Canada) that underwent a severe 12-year population decline followed by a rapid rebound. We genotyped archival scales sampled pre-crash and contemporary fin clips collected post-crash, revealing high coverage (>90% average genotyping across all individuals) and low genotyping error (<0.01% within-libraries, 0.60% among-libraries) despite the relatively poor quality of recovered DNA. We observed slight decreases in expected heterozygosity, allelic diversity, and effective population size post-crash, but none were significant, suggesting genetic diversity was retained despite the severe demographic contraction. Genotypic data also revealed the genetic distinctiveness of a now extirpated population just outside of KNPR, revealing biodiversity loss at the northern edge of the species distribution. More broadly, we demonstrate GT-seq as a valuable tool for genome-wide data collection from archival samples to address basic questions in ecology and evolution, and inform applied research in wildlife conservation and fisheries management.</p>
Characteristics of individuals with moderate to severe asthma who better respond to aerobic training: a cluster analysis
<p>Database used in the study's statistical analysis</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.