Find research datasets worth reusing

restrictedNov 2022View details →

Dataset related to article "Real-World Effectiveness of Denosumab and Bisphosphonates on Risk of Vertebral Fractures in Women with Breast Cancer Undergoing Treatment with Aromatase Inhibitors "

This record contains raw data related to article “Real-World Effectiveness of Denosumab and Bisphosphonates on Risk of Vertebral Fractures in Women with Breast Cancer Undergoing Treatment with Aromatase Inhibitors" Abstract Bone-active drugs are recommended to protect the skeleton from detrimental actions of aromatase inhibitors (AIs). However, most of literature data are focused on bone mineral density (BMD), whereas data on fractures are scant. The aim of this prospective study was to investigate the real-life effectiveness of denosumab, oral bisphosphonates (BPs) and intravenous zoledronate on risk of vertebral fractures (VFs) induced by AIs. 567 consecutive women (median age 62 years, range 28-83) with early breast cancer undergoing treatment with AIs were evaluated for morphometric VFs and BMD at baseline and after 18-24 months of follow-up. After enrollment, 268 women (47.3%) started denosumab 60 mg subcutaneously every 6 months, 115 (20.3%) BPs (59 with oral BPs and, 56 with intravenous zoledronate 5 mg/12 months), whereas 184 women (32.5%) were not treated with bone-active drugs for several reasons. During follow-up, 54 women (9.5%) developed incident VFs in association with age of subjects (P < 0.001), baseline FRAX scores for major fractures (P < 0.001) and hip fractures (P = 0.003), pre-existing VFs (P < 0.001), change in BMD at lumbar spine (P = 0.015), femoral neck (P = 0.003) and total hip (P < 0.001). Risk of VFs was higher in subjects who were untreated as compared to those treated with bone-active drugs (32/184 vs. 22/383; P < 0.001). Specifically, fracture risk was significantly decreased by denosumab [odds ratio (OR) 0.22; P < 0.001] and zoledronate (OR 0.27; P = 0.035), but not by oral BPs (P = 0.317). These data suggest that in real-world clinical practice, denosumab and zoledronate can reduce AI-related risk of VFs after only 24 months of treatment.

restrictedJan 2023View details →

Dataset related to article "Frozen Section Analysis and Real-Time Magnetic Resonance Imaging of Surgical Specimen Oriented on 3D Printed Tongue Model to Assess Surgical Margins in Oral Tongue Carcinoma: Preliminary Results"

This record contains raw data related to article “Frozen Section Analysis and Real-Time Magnetic Resonance Imaging of Surgical Specimen Oriented on 3D Printed Tongue Model to Assess Surgical Margins in Oral Tongue Carcinoma: Preliminary Results" Abstract Background: A surgical margin is the apparently healthy tissue around a tumor which has been removed. In oral cavity carcinoma, a negative margin is considered ≥ 5 mm, a close margin between 1 and 5 mm, and a positive margin ≤ 1 mm. Currently, the intraoperative surgical margin status is based on the visual inspection and tissue palpation by the surgeon and intraoperative histopathological assessment of the resection margins by frozen section analysis (FSA). FSA technique is limited and susceptible to sampling errors. Definitive information on the deep resection margins requires postoperative histopathological analysis. Methods: We described a novel approach for the assessment of intraoperative surgical margins by examining a surgical specimen oriented through a 3D-printed specific patient tongue with real-time Magnetic Resonance Imaging (MRI). We reported the preliminary results of a case series of 10 patients, prospectively enrolled, with oral tongue carcinoma who underwent surgery between February 2020 and April 2021. Two radiologists with 5 and 10 years of experience, respectively, in Head and Neck radiology in consensus evaluated specimen MRI and measured the distance between the tumor and the specimen surface. We performed intraoperative bedside FSA. To compare the performance of bedside FSA and MRI in predicting definitive margin status we computed the weighted sensitivity (SE), specificity (SP), accuracy (ACC), area under the ROC curve (AUC), F1-score, Positive Predictive Value (PPV), and Negative Predictive Value (NPV). To express the concordance between FSA and ex-vivo MRI we reported the jaccard index. Results: Intraoperative bedside FSA showed SE of 90%, SP of 100%, F1 of 95%, ACC of 0.9%, PPV of 100%, NPV (not a number), and jaccard of 90%, and ex-vivo MRI showed SE of 100%, SP of 100%, F1 of 100%, ACC of 100%, PPV of 100%, NPV of 100%, and jaccard of 100%. These results needed to be validated in a larger sample size of 21- 44 patients. Conclusion: The presented method allows a more accurate evaluation of surgical margin status, and the first clinical experiences underline the high potential of integrating FSA with ex-vivo MRI of the fresh surgical specimen.

restrictedJan 2023View details →

Hypocalcemia During Lenvatinib Treatment for Advanced Thyroid Cancer: Clinical Features and Management in a Real-Life Setting

Background: Several toxicities are recorded during treatment of advanced thyroid cancer (TC) with antiangiogenic drugs, including lenvatinib (LEN). Hypocalcemia was reported in registration studies, but little data are available from real-life cohorts. The aim of our study was to describe the incidence, characteristics, and the management of hypocalcemia in patients on LEN treatment. Methods: This is a retrospective cohort study of consecutive patients with advanced TC, treated with LEN for at least six months at a single tertiary center in Italy. Phosphocalcic metabolism was evaluated during treatment. Results: We included 25 patients treated for a mean of 29 ± 19 months (range 6-68 months). Hypocalcemia occurred in 6 of the 25 patients (24% [95% confidence interval 9.36-45.13%]), being of grade ≥3 in 2 of the 25 patients (8%), and recurrent in 4 of 6 patients (67%). The median time to hypocalcemia onset was 3 months (range 0.5-13 months) from starting LEN. No differences were found between patients who developed or not hypocalcemia regarding either starting/mean dose of LEN or clinicopathological characteristics. During the hypocalcemic crisis, the 2 patients with grade ≥3 hypocalcemia had low magnesium and low or inappropriately normal parathormone (PTH) levels, while 2 of 3 patients with grade 2 hypocalcemia had a secondary hyperparathyroidism. Hypocalcemia was managed with calcium oral supplementation in most cases, although up to 10% of patients required intravenous calcium treatment and transient LEN withdrawal. Conclusions: In this relatively small cohort, we observed an incidence of hypocalcemia of 24%, which is higher than that reported in the registration trial (6.9%). Both PTH-dependent and PTH-independent mechanisms explained hypocalcemia in the present cohort. Monitoring of serum calcium levels is strongly advised during the first year of LEN treatment, as hypocalcemia may be severe. More research is needed to confirm our findings and inform possible risk factors for hypocalcemia in advanced TC patients treated with LEN.

restrictedFeb 2023View details →

Dataset related to article "Biochemical Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors by Cardiovascular Risk Profile and Volume Status in a Real-World Diabetic Population "

This record contains raw data related to article “Biochemical Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors by Cardiovascular Risk Profile and Volume Status in a Real-World Diabetic Population" Abstract Despite large-scale randomized clinical trials (RCTs) highlighting a consistent prognostic benefit of sodium-glucose cotransporter 2 inhibitors (SGLT2is) both in diabetic patients at high cardiovascular risk and in those with heart failure, there is relative paucity of data on their biochemical effects in a real-world setting. We performed a retrospective analysis on consecutive diabetic patients who were prescribed a SGLT2i in a tertiary referral center and completed at least 1 year of treatment. Changes in glycated hemoglobin, weight, and hematocrit were compared across 2 cardiovascular risk categories, defined through the inclusion criteria of 3 large RCTs. Of the 459 patients screened, 312 completed 1 year of treatment (68.0%), 92 interrupted the treatment prematurely (20.0%), and 55 were lost to follow-up (12.0%). The most common cause of drug discontinuation was genital or urinary tract infections (9.4%). At 1 year, reduction in glycated hemoglobin concentration (-0.7 ± 1.5%, P < 0.001) and body weight (2.4 ± 4.6 kg, P < 0.001) was comparable between patients at high versus low cardiovascular risk, while hematocrit increase (2.3 ± 3.3%, P < 0.001) was more marked in patients with high cardiovascular risk and low baseline hematocrit. In a real-world population of diabetic patients, SGLT2is were well-tolerated at 1 year and led to improved glycemic control and weight loss. Hematocrit increase was more consistent in patients with high cardiovascular risk and signs of fluid overload, indicating euvolemic restoration as a potential cardioprotective mechanism mediated by these compounds.

restrictedFeb 2023View details →

The Real Purpose Of Life

It is often said that the meaning and purpose of life is an elusive and often personal question. But what is the real purpose of life?The answer may be simpler than you think. The real purpose of life is to be happy. Not just happy in the moment, but truly happy and content with your life as a whole.Of course, this is easier said than done. Life can be full of challenges and hardships that make happiness seem out of reach. But even in the darkest of times, there is always the potential for happiness.     The key is to find what brings you joy and to hold onto that joy, no matter what. It might be your family, your friends, your hobbies, your work, or anything else that brings a smile to your face. Whatever it is, cherish it and let it fill your life with purpose. Because in the end, that’s all that really matters.

restrictedApr 2023View details →

Efficacy of biological larvicide VectoMax® FG against Aedes albopictus and Culex pipiens under real field conditions in urban catch basins

This database has been used to evaluate the efficacy of biological larvicide VectoMax® FG against Aedes albopictus and Culex pipiens under real field conditions in urban catch basins

restrictedMay 2023View details →

Real-time MRI monitoring of liquid embolic agent (Onyx) injection in a swine arteriovenous malformation model.

Movie 1 Real-time, dynamic EPI-GRE T2 scan of the whole brain volume during Onyx injection. Cine sequence of the ONYX propagation at the level of the pons. Dark liquid embolic agent is gradually filling small arteries around the pons.    Movie 2 Real-time dynamic EPI-GRE MRI monitoring of the test infusion of diluted gadolinium (10mM) seen as a short wash-in and wash-out of hypointense signal, confirming the proper position of the microcatheter and verifying the area of trans-catheter perfusion.

restrictedJul 2023View details →

Theory of Mind assessed via real life materials in Chronic Migraine with Medication Overuse.

Dataset refers to a study aimed to outline the Theory of Mind (ToM) functioning of patients with Chronic Migraine with Medication Overuse (CM+MO) compared to Episodic Migraine (EM) using the Movie for the Assessment of Social Cognition (MASC), a task consisting of the presentation of a 15-minute video clip of social interactions close to real life encounters in which participants are asked to identify and attribute mental states online. Seventy-two subjects were enrolled, of which 30 suffered from CM+MO and 42 from EM. All participants were assessed with a conventional ToM task, the Reading Mind in the Eyes test (RMET), and the MASC. We confirm impaired ToM performances in CM+MO with respect to EM when using the RMET. Interestingly, we also found that CM+MO when compared to EM were characterized by more marked deficits in the affective ToM dimension of the MASC with respect to the cognitive one and committed more hypomentalizing errors. This means that CM+MO patients may be more prone to under-interpret and misunderstand intended social interaction from another human being than the EM group. These findings have important theoretical and practical relevance in the field of CM+MO.

restrictedFeb 2023View details →

EmpathicSchool: A multimodal dataset for real-time facial expressions and physiological data analysis under different stress conditions

EmpathicSchool is a novel dataset that captures facial expressions and the associated physiological signals, such as heart rate, electrodermal activity, and skin temperature, under different stress levels. The data was collected from 30 participants at different sessions for 42 hours. The data includes 7 different signal types, including both computer vision and physiological features that can be used to detect stress. In addition, various experiments were conducted to validate the signal quality. The data will be available upon signing the Data Usage Agreement.

openGEO-OpenApr 2022View details →

Real-time quantitative PCR analysis of microRNAs in serum

GEO Series GSE201656. Homo sapiens. 3 samples. Type: Other.

openGEO-OpenMay 2022View details →

Real-time quantitative PCR analysis of autophagy and apoptosis in Myelodysplastic syndromes (MDS)

GEO Series GSE204797. Homo sapiens. 13 samples. Type: Expression profiling by RT-PCR.

openGEO-OpenJul 2022View details →

Exposure to a real traffic environment impairs brain cognition in aged mice

GEO Series GSE208109. Mus musculus. 8 samples. Type: Methylation profiling by high throughput sequencing.

openGEO-OpenFeb 2017View details →

Real-time quantitative PCR analysis of healthy and HCV-infected Child-B cirrhotic patients

GEO Series GSE93234. Homo sapiens. 18 samples. Type: Expression profiling by RT-PCR.

nasa12/100

GO JUP EPD REFORMATTED REAL TIME SCAN AVERAGED V1.0

This data set contains 11 min resolution RTS 16 sector rate, pitch, and phase data for all Jupiter orbits. There are a total of 18 tabulated data files that contain A1, A2, A3, A4, A5, E1, F2, TP1, TP2, TA1, TO1, TO2, TO3, TS1, TS2, Start, Pitch, and Phase 16 sector data. The rates reported are in units of (counts/sec), pitch and phase angles are in (radians).

restrictednotspecifiedMar 2025View details →

restrictedFeb 2020View details →

data related to the article titled: "A Sex-based analysis from the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life) on Left-main stenting

This record contains raw data related to the article “"A Sex-based analysis from the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life) on Left-main stenting"   abstract:  Introduction. There is a lack of data on clinical outcomes of percutaneous coronary intervention (PCI) with ultrathin stents on unprotected left main (ULM) coronary artery comparing women  and men. Methods. All patients treated with ULM PCI with ultrathin stents (struts ≤  81 µm) enrolled in the RAIN-cardiogroup VII Study were analysed according to a sex-assessment evaluation. Major adverse cardiovascular events (MACE: a composite of all cause death, myocardial infarction, target lesion revascularization [TLR] and stent thrombosis) were the primary end-point, whereas single components of MACE were the secondary end-points. Results. Out of a cohort of 793 patients, 172 (21.7%) women and 621 (78.3%) men were included. Compared to men, women were older and less frequently smokers, had more frequently a history of previous PCI and presented more frequently with an acute coronary syndrome. Among women, ostial lesions were more prevalent and mean diameter stent was lower compared to men. After 13.4 (8.4-21.6) months, 32 (18.6%) women and 106 (17.1%) men experienced MACE (p=0.64). Censoring follow-up data at 3 years, no differences were observed in MACE (16.9 vs 14.7 per 100*pts/years, log-rank p=0.61) and their single components between women and men. At multivariate analysis, chronic kidney disease (HR 1.91: 1.23 -2.95, p=0.004) and acute coronary syndrome presentation (HR 1.84: 1.22-2.77, p=0.013) were independent predictors of MACE overall. Larger stent size (HR 0.65, 95% CI 0.48-0.89, p=0.007) and longer double antiplatelet therapy duration (HR 0.95, 95% CI 0.90-0.99, p=0.032) were associated with a reduced risk of MACE during the subsequent follow-up Conclusion. Ultrathin stents offer low rates of MACE and TLR in the overall population without significant differences between sexes.

restrictedDec 2020View details →

Sacubitril/valsartan use in a real-world population of patients with heart failure and reduced ejection fraction

This record contains raw data related to the article “Sacubitril/valsartan use in a real-world population of patients with heart failure and reduced ejection fraction”   Aims: Practice guidelines recommend sacubitril/valsartan for heart failure with reduced ejection fraction. The aim of our study was to describe the use of sacubitril/valsartan in real-world clinical practice to help identify patients best able to tolerate titration to higher doses. Methods: We retrospectively analyzed clinical data for 201 patients with heart failure with reduced ejection fraction prescribed sacubitril/valsartan at our heart failure clinic (Centro Cardiologico Monzino) between September 2016/December 2018. Patients had a mean age of 67.2 years, mean left ventricular ejection fraction of 30.1%, New York Heart Association class II (65%), class III (35%), and poor cardiopulmonary exercise capacity. Median 2-year risk of death/urgent cardiac transplantation was 8.9% [Metabolic Exercise Cardiac Kidney Index (MECKI) score]. Results: After a median follow-up of 230 (interquartile interval: 105-366) days, 57 patients achieved higher-dose sacubitril/valsartan, 103 tolerated medium/low doses, nine died, and 20 interrupted treatment. The highest dose of sacubitril/valsartan was reached by younger patients with better hemoglobin (Hb) levels, renal function, and blood pressure (BP). Patients continuing on sacubitril/valsartan had significantly higher serum Hb and sodium, better BP, and lower MECKI scores than patients who discontinued treatment or died during follow-up. Our patients were older and frailer than those in the pivotal PARADIGM-HF trial. Conclusion: In our experience, more than one-third of the patients were able to tolerate the higher dose of sacubitril/valsartan, and these patients were younger, had higher Hb, and better BP and renal function. MECKI score stratification was useful to discriminate patients who continued treatment from those who did not. Future prospective studies should test if these clinical variables can guide the up-titration of sacubitril/valsartan.

restrictedSep 2021View details →

Real-life Effectiveness and Safety of Risankizumab in Moderate-to-severe Plaque Psoriasis: A 40-week Multicentric Retrospective Study

Risankizumab is a humanized monoclonal antibody that binds the p19 subunit of interleukin-23. It is approved for treatment of moderate-severe chronic plaque psoriasis. This retrospective study included 66 consecutive adults with moderate-to-severe psoriasis vulgaris treated with risankizumab in monotherapy up to week 40 in a “real-life” setting. At week 40, 98.7%, 85.7% and 62.3% of patients achieved a Psoriasis Area and Severity Index (PASI) reduction ≥75% (PASI 75), PASI 90 and PASI 100, respectively. Patients who had not responded to 2 or more previous biologic treatments were significantly less likely to achieve PASI 75/90 at week 16 and PASI 90/100 at week 40 compared with those who had been previously treated with only 1 biologic, and compared with those treated with risankizumab as a first-line biologic. Increasing body mass index decreased the chances of reaching PASI 90 at week 40. No significant safety findings were recorded throughout the study, and none of the patients had to interrupt the treatment. These data suggest that the efficacy of risankizumab for plaque psoriasis in “real-life” clinical practice could differ from pivotal clinical trials data.

restrictedApr 2022View details →

A contribution to real-time space weather monitoring based on scintillation observations and IoT

Here, all field measurements acquired for the article entitled: ''A contribution to real-time space weather monitoring based on scintillation observations and IoT'', by Santos Freitas et al (2022) in Advances in Space Research are made available. The Scintapp is also available for download. Details on the data format can be found in section 2 of the aforementioned article.

restrictedJan 2022View details →

Real-time PAAO

Real-time thickness measurements <ul> <li>Originals - Directory with all saved spectra with preserved timestamps</li> <li>Organized files - Directory with processed data <ul> <li>1. Pre anodizing spectrum - Directory with spectra before anodization process</li> <li>2. Anodizing spectrum - Directory with spectra during anodization process</li> <li>3. Post anodizing spectrum - Directory with spectra after anodization process</li> <li>4. Anodizing Plots - Directory with images of spectra and fitted spectra during an anodization process</li> <li>5. Anodizing Data - Directory with tab delimited data of spectra and fitted spectra during an anodization process. (1st column: Wavelength (nm); 2nd column: Experimental reflection(a.u.); 3rd column: Fitted reflection (a.u.))</li> <li>Current_per_time.dat - tab delimited data for current dependence on anodization time (1st column: Anodization time (s); 2nd column: Current (mA))</li> <li>Thickness_per_time.dat - tab delimited data for PAAO thickness dependence on anodization time (1st column: Anodization time (s); 2nd column: Thickness (nm))</li> <li>Thickness_per_time.png - plot of PAAO thickness dependence on anodization time</li> <li>Anodization_parameters.txt - data containing information about anodization parameters ( Voltage, Temperature, etc.)</li> </ul> </li> </ul> Zip file name consists of: 1.Date 2.Time 3.Desired_Thickness 4.Fitted_Thickness 5.Anod_time 6.Temperature 7.Voltage 8.Solution 9.Material.zip Project: Nanostructured multilayer hybrid coatings for interferometric and optoelectronic sensors (LZP-2020/1-0200)