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Dataset results
436 results for “Autoimmune diseases”
HERV1-env dependent unfolded protein response activation is a potential initiator of T cell autoreactivity in autoimmune liver disease.
GEO Series GSE135410. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TOX drives TH1 CD4+ T cell effector function, anti-tumor immunity, and pathogenicity in autoimmune diseases
GEO Series GSE317904. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset for the project "Identifying disease signatures of neurodegenerative dementias: a focus on autoimmunity and inflammation" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2019-12369272)
<p><strong><span>Dataset for the project “Identifying disease signatures of neurodegenerative dementias: a focus on autoimmunity and inflammation” Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2019-12369272)</span></strong></p> <p><strong><span>Specific Aim 1</span></strong></p> <p><span>To identify an immune-system genetic profile associated with disease onset, clinical phenotype and progression in AD and FTLD patients</span></p> <p><strong><span>Specific Aim 2</span></strong></p> <p><span>To identify an inflammatory/autoimmune biochemical signature associated with disease onset, clinical phenotype and progression in AD and FTLD patients</span></p> <p><strong><span>Specific Aim 3</span></strong></p> <p><span>To study the molecular mechanism involved in anti-GluA3 mediated synaptic, cellular and functional dysfunctions leading to neurodegeneration</span></p> <p><span>The present dataset contains the following folders:</span></p> <ul> <li><strong><span>Aim1:</span></strong><span> </span></li> <ul> <li><span>gVCF: a folder containing all gVCF files for each sample sequenced</span></li> <li><span>Correspondence: a dataset (excel file) containing sample name, group and corresponding g.vcf file name</span></li> <li><span>Gene selected for panel design: an excel file with the 50 genes included in the NGS panel</span></li> <li><span>RawData-RF2019_variants: an excel file containing results included in an article published in IJMS (Int J Mol Sci. 2024; 25(13):7457. doi: 10.3390/ijms25137457) already openly available in the Zenodo Data Repository at doi: 10.5281/zenodo.11659282.</span></li> </ul> </ul> <ul> <li><strong><span>Aim2</span></strong><span>: </span></li> <ul> <li><span>NTA_file: a folder containing Raw NTA file for each sample (from these files we extracted EV concentration and size)</span></li> <li><span>Anti-GluA3_analyses: a dataset (excel file) containing ID sample, diagnosis, group, Anti-GluA3 values from ELISA assay</span></li> <li><span>Biochemical_analyses_UO1: a dataset (excel file) containing sample, group, Raw NTA File name and MHC-II levels from ELISA assay</span></li> <li><span>Biochemical_analyses_UO2: a dataset (excel file) containing sample, group, cytokine/chemokine (Eotaxin, Eotaxin-3, IFN gamma, IL-1 beta, IL-6, IL-8, IL-10, IL-12p70, IP-10, MCP-1, MIP-1 beta, TARC, TNF alpha and IL-17A) levels from Luminex assay</span></li> </ul> </ul> <ul> <li><strong><span>Aim3:</span></strong><span> Results from aim 3 have been included in an article published in Brain, Behavior and Immunity (</span><span>Brain Behav Immun. 2024 May;118:380-397. doi: 10.1016/j.bbi.2024.03.018</span><span>).</span></li> <ul> <li><span>Behaviour: a folder containing datasets and raw data regarding different batches of behavioural analyses</span></li> <li><span>Biochemistry: a folder containing raw data regarding different western blot analyses</span></li> <li><span>Spine_Morphology</span><span>:</span><span> a folder containing datasets and raw data regarding spine morphology</span><span> analyses</span></li> </ul> </ul> <p><span>Users must clarify how they intend to use data here uploaded and whether the research protocol has been approved by an Ethics committee. Data on unpublished results will be available, under the same restrictions, after publication.</span></p>
Dataset related to article "Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases"
<p>This record contains data related to article "Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases"</p> <p>The purpose of this study was to evaluate the efficacy and safety of the Moderna-1273 mRNA vaccine for SARS-CoV-2 in patients with immune-mediated diseases under different treatments. Anti-trimeric spike protein antibodies were tested in 287 patients with rheumatic or autoimmune diseases (10% receiving mycophenolate mofetil, 15% low-dose glucocorticoids, 21% methotrexate, and 58% biologic/targeted synthetic drugs) at baseline and in 219 (76%) 4 weeks after the second Moderna-1273 mRNA vaccine dose. Family members or caretakers were enrolled as the controls. The neutralizing serum activity against SARS-CoV-2-G614, alpha, and beta variants in vitro and the cytotoxic T cell response to SARS-CoV-2 peptides were determined in a subgroup of patients and controls. Anti-SARS-CoV-2 antibody development, i.e., seroconversion, was observed in 69% of the mycophenolate-treated patients compared to 100% of both the patients taking other treatments and the controls (p &amp;lt; 0.0001). A dose-dependent impairment of the humoral response was observed in the mycophenolate-treated patients. A daily dose of &amp;gt;1 g at vaccination was a significant risk factor for non-seroconversion (ROC AUC 0.89, 95% CI 0.80-98, p &amp;lt; 0.0001). Moreover, in the seroconverted patients, a daily dose of &amp;gt;1 g of mycophenolate was associated with significantly lower anti-SARS-CoV-2 antibody titers, showing slightly reduced neutralizing serum activity but a comparable cytotoxic response compared to other immunosuppressants. In non-seroconverted patients treated with mycophenolate at a daily dose of &amp;gt;1 g, the cytotoxic activity elicited by viral peptides was also impaired. Mycophenolate treatment affects the Moderna-1273 mRNA vaccine immunogenicity in a dose-dependent manner, independent of rheumatological disease.</p>
In vivo CRISPR screening in autoimmune disease model reveals differential dependence of Th1 and Th17 cells on amino acid transporter SNAT1
GEO Series GSE190131. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
MSCs-encapsulated porous microparticle eye drops for autoimmune dry eye disease treatment
GEO Series GSE295017. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
TOX drives TH1 CD4+ T cell effector function, anti-tumor immunity, and pathogenicity in autoimmune diseases [CUT&RUN]
GEO Series GSE317910. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
An autoimmune disease risk variant has a trans master regulatory effect mediated by IRF1 under immune stimulation
GEO Series GSE145487. Homo sapiens. 114 samples. Type: Expression profiling by high throughput sequencing.
Uncoupling the two distinct roles of targeting BDCA2 in treating autoimmune diseases: direct inhibition of BDCA2-positive B cells and normalization of proinflammatory monocyte-derived macrophages via
GEO Series GSE314089. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Dissecting the genetics of cutaneous miRNA in a mouse model of autoimmune bullous disease
GEO Series GSE64276. synthetic construct; Mus musculus. 100 samples. Type: Non-coding RNA profiling by array.
TOX drives TH1 CD4+ T cell effector function, anti-tumor immunity, and pathogenicity in autoimmune diseases [RNA-Seq]
GEO Series GSE317909. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in B cells from mice with the autoimmune disease nephrotoxic nephritis
GEO Series GSE29923. Mus musculus. 2 samples. Type: Expression profiling by array.
Cytochrome P450 1B1 directs pathogenic-Th17 cell generation and autoimmune disease by maintaining cellular redox homeostasis and mitochondrial function
GEO Series GSE302396. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling [V]
GEO Series GSE247616. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Genetic landscape and autoimmunity of monocytes in developing Vogt-Koyanagi-Harada disease
GEO Series GSE148020. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
PTEN-induced kinase 1 (PINK1) ameliorates autoimmune disease via negative regulation of the STAT3-Th17 axis
GEO Series GSE254099. Mus musculus. 2 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.