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opencc-by-4.0Oct 2021View details →

Agonistic analog of growth hormone-releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke Dataset

Agonistic analog of growth hormone-releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke Dataset R19111110_BKDL192544031-Sham 1 R19111110_BKDL192544032-Sham 2 R19111110_BKDL192544033-Sham 3 R19111110_BKDL192544034-Sham 4 R19111110_BKDL192544035-Model 2 R19111110_BKDL192544036-Model 3 R19111110_BKDL192544037-Model 4 R19111110_BKDL192544038-Model 5 R19111110_BKDL192544039-Model 1 R19111119_BKDL192544040-Model+Drug 1 R19111119_BKDL192544041-Model+Drug 2 R19111119_BKDL192544042-Model+Drug 3 R19111119_BKDL192544043-Model+Drug 4 R19111119_BKDL192544044-Model+Drug 5

opencc-zeroDec 2016View details →

Data from: Predation, metabolic priming and early life-history rearing environment affect the swimming capabilities of growth hormone transgenic rainbow trout

The period of first feeding, when young salmonid fishes emerge from natal stream beds, is one fraught with predation risk. Experiments conducted in semi-natural stream mesocosms have shown that growth hormone transgenic salmonids are at greater risk of predation than their non-transgenic siblings, due partly to the higher metabolic demands associated with transgenesis, which force risky foraging behaviours. This raises questions as to whether there are differences in the swim-performance of transgenic and non-transgenic fishes surviving predation experiments. We tested this hypothesis in wild-origin rainbow trout (Oncorhynchus mykiss) that were reared from first feeding in semi-natural stream mesocosms characterized by complex hydrodynamics, the presence of predators and oligotrophic conditions. Using an open-flume raceway, we swam fish and measured their capacity for burst-swimming against a sustained flow. We found a significant genotype effect on burst-performance, with transgenic fish sustaining performance longer than their wild-type siblings, both in predator and predator-free stream segments. Importantly, this effect occurred before differences in growth were discernable. We also found that mesocosm-reared fish had greater burst-performance than fish reared in the controlled hatchery environment, despite the latter being unexposed to predators and having abundant food. Our results suggest a potential interaction between predation and metabolic priming, which leads to greater burst capacity in transgenic trout.

opencc-by-4.0Jun 2022View details →

''Eight-year efficacy update of the HOBOE randomized phase 3 trial in premenopausal patients with hormone-receptor positive early breast cancer comparing triptorelin plus either Tamoxifen or Letrozole or Zoledronic acid + Letrozole'' - dataset

Dataset for analysis of the manuscript ''Eight-year efficacy update of the HOBOE randomized phase 3 trial in premenopausal patients with hormone-receptor positive early breast cancer comparing triptorelin plus either Tamoxifen or Letrozole or Zoledronic acid + Letrozole''

opencc-zeroAug 2022View details →

Evaluation of assisted reproductive technology treatment outcomes based on stimulation dosages and anti-mullerian hormone levels

Background: Serum concentrations of anti-mullerian hormone (AMH) correlate with ovarian response during assisted reproductive (ART) treatment cycles. This prospective study was attempted to evaluate the selection of ovarian stimulation protocols based on serum AMH levels in patients and its impact on the results of ART. Results According to the AMH levels, majority of the patients were normal responders (52.4%) followed by high responders (29.8%) and low responders (17.8%). The average FSH, HMG per day and number of days HMG required was found to be significant among the different responders. Further, retrieval rate and blastulation rate was found to be significant among the different responders. A positive correlation was found between AMH and number of oocytes retrieved and number of oocytes successfully fertilized and it was found to be significant. In addition, there was a significant inverse relationship between AMH levels and age. Conclusion The study outcome reveals that retrieval rate, maturation rate, fertilization rate, embryo utilization rate and blasturation rate were higher among the high responders as compared to low responders. Thus, proper increase in dosages of ovarian stimulation protocol is required among the low responders to achieve quality embryos.

opencc-by-4.0Aug 2022View details →

A promising target for non-hormonal contraception – The a/b Hydrolase Domain 2

Summary of results in 2022 for a/b Hydrolase Domain 2 (ABHD2) in the scope of the Structural Genomics Consortium's Women’s and Children’s Health Initiative funded by the Bill & Melinda Gates Foundation for characterizing potential targets for new non-hormonal contraceptives.

opencc-by-4.0Apr 2019View details →

High-throughput phenotyping of salt-stress responses of the selected Arabidopsis hormone mutants

This data was collected using Hight Throughput Phenotyping machine (psi.cz) purchased by KAUST in January 2018. The plants were germinated and grown under 12/12 light/dark light regime, 22C, 60% humidity for two weeks. After two weeks, half of the plants were exposed to approximately 100 mM NaCl (protocol described in Awlia et al., 2016, Frontiers in Plant Sci, <a href="https://doi.org/10.3389/fpls.2016.01414">https://doi.org/10.3389/fpls.2016.01414</a>). The rosettes of the plants were subsequently phenotyped using the Thermal Camera, RGB, and Chlorophyll Fluorescence camera (in this order). Chlorophyll fluorescence was measured after 15 minutes of dark adaptation using the "LightCurve2" protocol.  The description of the traits is available in the notebook available at <a href="https://github.com/mmjulkowska/PSI_notebook">https://github.com/mmjulkowska/PSI_notebook</a>

Fig. 6 in Hormonal Regulation of Testicular Development in the Finless Porpoise Neophocaena asiaeorientalis sunameri: Preliminary Evidence from Testicular Histology and Immunohistochemistry

Fig. 6. Immuno-expression of AR (A:3.5yr.) and ERβ (B: 0.1yr., C: 3.5yr. and D: 8yr.) in testes. Scale bar = 50 µm.

Figure 2 shows a in Hormonal Regulation of Testicular Development in the Finless Porpoise Neophocaena asiaeorientalis sunameri: Preliminary Evidence from Testicular Histology and Immunohistochemistry

Figure 2 shows a longitudinal slice of a tooth consisting of translucent and opaque zones under the transmitted light. The tooth is clearly divided into two parts by a highlighted neonatal line. The part inside of the neonatal line is dentine, and the outside is cementum. Ages were counted by GLGs in dentine, and basic data are shown in table 1. The oldest individual was 13 years old, while the youngest ones died about a month after birth.

Fig. 3 in Hormonal Regulation of Testicular Development in the Finless Porpoise Neophocaena asiaeorientalis sunameri: Preliminary Evidence from Testicular Histology and Immunohistochemistry

Fig. 3. Histological sections of testes from birth to adulthood. LC: Leydig cells; SC: Sertoli cells; PG: Primordial germ cells; SG: Spermatogonia; PS: Primary spermatocytes; SS: Secondary spermatocytes; SPZ: Spermatozoa. (A) 0.1yr. (B) 2.5yr. (C) 3yr. (D) 3.5yr. (E) 4.5yr. (F) 6yr. (G) 8yr. (H) 13yr. Scale bar = 50 µm.

Fig. 2 in Hormonal Regulation of Testicular Development in the Finless Porpoise Neophocaena asiaeorientalis sunameri: Preliminary Evidence from Testicular Histology and Immunohistochemistry

Fig. 2. Growth layer groups (GLGs) in the thin section of a tooth. One GLG consists of an opaque layer and a translucent layer. The arrow represents the neonatal line. Scale bar = 200 µm.

Fig. 5 in Hormonal Regulation of Testicular Development in the Finless Porpoise Neophocaena asiaeorientalis sunameri: Preliminary Evidence from Testicular Histology and Immunohistochemistry

Fig. 5. Immunoexpression of testosterone (A: 0.1yr, B: 3.5yr and C: 8yr) and estradiol (D: 0.1yr, E: 3.5yr and F: 8yr) in testes from birth to adulthood. Upper insert on panel A: negative control. Black arrows represent spermatozoa. Scale bar = 50 µm. © 2018 Academia Sinica, Taiwan

Fig. 4 in Hormonal Regulation of Testicular Development in the Finless Porpoise Neophocaena asiaeorientalis sunameri: Preliminary Evidence from Testicular Histology and Immunohistochemistry

opencc-by-4.0May 2024View details →

Data deposit for "Resolving sulfation post-translational modifications on a peptide hormone using nanopores"

Data and code deposit for the <a href="https://www.biorxiv.org/content/10.1101/2024.05.08.593138v1" target="_blank" rel="noopener">pre-print</a> and the <a href="https://doi.org/10.1021/acsnano.4c09872">published</a> manuscript at ACS nano. See README.md for more information.

opencc-zeroDec 2017View details →

Data from: Systemic thyroid hormone status during levothyroxine therapy in hypothyroidism: a systematic review and meta-analysis

CONTEXT: The standard of care for overt hypothyroidism is levothyroxine at doses that normalize serum TSH levels. Whether this approach universally restores thyroid hormone signaling is unknown. OBJECTIVE: To review studies of overt hypothyroidism in which participants were treated with levothyroxine to normalize serum TSH levels and measured other objective markers of thyroid hormone signaling. DESIGN: Databases were searched for studies that reported objective markers of thyroid hormone signaling (serum low-density lipoprotein (LDL), total cholesterol (TC), sex hormone-binding globulin (SHBG), creatine kinase and/or ferritin levels; cognition, energy expenditure, and/or renal function) in levothyroxine monotherapy for overt, primary hypothyroidism among nonpregnant adults with normal serum TSH levels. For studies with LDL, TC and SHBG outcomes, data were pooled using random effects meta-analysis. RESULTS: A total of 99 studies met inclusion criteria, including 65 that reported serum cholesterol data. Meta-analysis showed that levothyroxine-treated hypothyroid participants with normal serum TSH levels had 3.31 ± 1.64 mg/dL higher serum LDL levels (p=0.044) and 9.60 ± 3.55 mg/dL higher serum TC levels (p=0.007) compared to controls. In studies that did not concomitantly assess healthy controls, serum LDL levels were 138.3 ± 4.6 mg/dL (p<0.001) and serum TC levels were 209.6 ± 3.4 mg/dL (p<0.001). Meta-analysis of 2 studies showed no significant difference between SHBG levels of levothyroxine-treated participants and controls. CONCLUSIONS: In studies that utilized levothyroxine monotherapy at doses that normalized the serum TSH for overt, primary hypothyroidism, not all systemic biological markers of thyroid hormone signaling were normalized, including serum LDL and TC levels.

opencc-by-4.0Aug 2021View details →

X-ray diffraction images of juvenile hormone diol kinase from the silk worm Bombyx mori

X-ray diffraction images of juvenile hormone diol kinase (JHDK) from the silk worm Bombyx mori

opencc-zeroMay 2023View details →

Data for: Associations between faecal chemical pollutants and hormones in primates inhabiting Kibale National Park, Uganda

While anthropogenic pollutants are known to be a threat to primates, our understanding of exposure to pollutants in situand their sub-lethal effects is still limited. We used noninvasive biomonitoring to examine associations between fecal concentrations of 97 chemical pollutants and fecal hormone metabolites of cortisol and estradiol in four primate species inhabiting Kibale National Park, Uganda (chimpanzees - Pan troglodytes, olive baboons - Papio anubis, red colobus - Piliocolobus tephrosceles, and red-tailed monkeys - Cercopithecus ascanius). Across all species (n = 71 samples), our results demonstrated positive associations of organochlorine pesticides (ß = 0.143, p = 0.020) and organophosphate esters (ß = 0.112, p = 0.003) with cortisol in adult females. Additionally, we observed positive associations of organochlorine pesticides (ß = 0.192, p = 0.013) and brominated flame retardants (ß = 0.176, p = 0.004) with cortisol in juveniles. Our results suggest that cumulative pesticides and flame retardants are disruptive to endocrine function in these populations, which could have implications for development, metabolism, and reproduction. Our results further demonstrate that feces can be an important, noninvasive matrix for examining pollutant-hormone associations in wild primates and other critical wildlife populations.

Fig. 8 in Relative contribution of LOX10, green leaf volatiles and JA to woundinduced local and systemic oxylipin and hormone signature in Zea mays (maize)

Fig. 8. Volatiles emitted in wounded leaves of WT, lox10 and opr7opr8. (A) GLVs; (B) 13-LOX-derived C5 volatiles; (C) Volatile terpenes and indole. Volatiles were collected for 1 h after wounding. Values are mean ± standard error (n = 6). Different letters show significant differences (one-way ANOVA, S–N–K, P <0.05).

Fig. 5. 13 in Relative contribution of LOX10, green leaf volatiles and JA to woundinduced local and systemic oxylipin and hormone signature in Zea mays (maize)

Fig. 5. 13-LOX-derived oxylipin accumulation in leaves of WT (blue squares), lox10 (red circles) and opr7opr8 (green triangles) after wounding treatment. Values are mean ± standard error (n ≥ 4). Statistical differences are presented in Supplemental Fig. S2.

Fig. 6 in Relative contribution of LOX10, green leaf volatiles and JA to woundinduced local and systemic oxylipin and hormone signature in Zea mays (maize)

Fig. 6. α-DOX-derived 2-HOD and ROS-generated 10-HOD accumulation in leaves of WT (blue squares), lox10 (red circles) and opr7opr8 (green triangles) after wounding treatment. Values are mean ± standard error (n ≥ 4). Statistical differences are presented in Supplemental Fig. S2.

Fig. 2 in Relative contribution of LOX10, green leaf volatiles and JA to woundinduced local and systemic oxylipin and hormone signature in Zea mays (maize)

Fig. 2. Basal levels of oxylipins in leaves of WT, lox10 and opr7opr8. (A) 9-LOX-derived products; (B), (C) and (D) 13-LOX-derived products; (E) α-DOX-derived 2- HOD and 10-HOD generated by reactive oxygen species (ROS). Values are mean ± standard error (n ≥ 4). Different letters show significant differences (one-way ANOVA, S–N–K, P <0.05).