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444
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ShareScore release 0.9.0
Dataset results
444 results for “PRC2”
Profiling of PRC1 and PRC2 occupancy reveals the preponderant role of PRC1 in regulating the limb development program [ChIP-seq]
GEO Series GSE186574. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Interplay between Nsd1 and PRC2 demarcates regions of H3K27me2 and H3K27me3
GEO Series GSE86925. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
In embryo analysis of H3K27 trimethylation suggests a two-step process involving PRC2 interacting sequences and high GC content
GEO Series GSE43915. Mus musculus. 41 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Dual interactions of K27M mutant nucleosomes with PRC2 and MLL1 shape the cancer epigenetic landscape
GEO Series GSE163184. Homo sapiens. 91 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization [ChIP-Seq]
GEO Series GSE278811. Mus musculus. 77 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Selective lymphoma cell killing by a PRC2 small molecule inhibitor (RNA-Seq)
GEO Series GSE40475. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
INO80 complex assembly is antagonized by PRC2.
GEO Series GSE97413. Homo sapiens. 57 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
PHF19 drives PRC2 sub-nuclear compartmentalization to promote motility in TNBC cells [ChIP-seq]
GEO Series GSE291242. Homo sapiens. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Polycomb Repressive Complexes occupancy reveals PRC2- independent PRC1 critical role in the control of limb development [RNA-seq]
GEO Series GSE216808. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Polycomb Repressive Complexes occupancy reveals PRC2- independent PRC1 critical role in the control of limb development
GEO Series GSE216809. Mus musculus. 35 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Top2a Differentially Modulates Promoter Activity in Embryonic Stem Cells via Trim28 Recruitment and PRC2 Displacement [ChIP-Seq]
GEO Series GSE257545. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define pre-malignant neurofibromatosis type 1-associated atypical neurofibromas
Neurofibromatosis type 1 (NF1) is a tumor-predisposition disorder caused by germline mutations in NF1. NF1 patients have an 8-16% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST), a highly aggressive soft-tissue sarcoma, often arising from pre-existing benign plexiform neurofibromas (PN) and atypical neurofibromas (ANF). ANF are distinct from both PN and MPNST, representing an intermediate step in malignant transformation. In the first comprehensive genomic analysis of ANF, we performed tumor/normal exome sequencing (ES) of 16 ANFs. In addition, we conducted ES of three MPNSTs, copy-number meta-analysis of 26 ANF and 28 MPNST, and whole transcriptome RNA-seq analysis of five ANF and five MPNST. We identified low mutation burden (median 1, range 0-5) in the exomes of ANF (only NF1 somatic mutations were recurrent), and frequent deletions of CDKN2A/CDKN2B (69%) and SMARCA2(42%) loci. We determined that polycomb repressor complex 2 (PRC2) genes EED or SUZ12 were frequently mutated, deleted or downregulated in MPNST but not in ANF. Our gene expression study revealed upregulated NRAS, MDM2, CCND1/CCND2/CCND3 and CDK4/CDK6 in both ANF and MPNST, and overexpression of EZH2 in MPNST only. We conclude that the PN-ANF transition is primarily driven by the deletion of CDKN2A/CDKN2B in addition to already present inactivated NF1. Further progression from ANF to MPNST likely involves broad chromosomal rearrangements and frequent inactivation of the PRC2 genes, loss of the DNA repair genes, and copy-number increase of signal transduction, cell cycle and pluripotency self-renewal genes.
H3 K27M and EZHIP impede H3K27-methylation spreading by inhibing allosterically stimulated PRC2 [S2_ATAC]
GEO Series GSE151981. Drosophila melanogaster. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
EZH2 inhibition results in genome-wide PRC2 redistribution in cancer cell models
GEO Series GSE134136. Homo sapiens. 44 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and PRC2 dependence
GEO Series GSE240151. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcription factors PLT and chromatin regulators PRC2 and JMJ703 form nuclear condensates to maintain gene repression in bivalent domains controlling cell fate in rice root meristem
GEO Series GSE251804. Oryza sativa Japonica Group. 26 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Selective lymphoma cell killing by a PRC2 small molecule inhibitor (Exon array)
GEO Series GSE40474. Homo sapiens. 2 samples. Type: Expression profiling by array.
Omics of FBXO11-Mediated Proteolysis of BAHD1 Relieves PRC2-dependent Transcriptional Repression in Erythropoiesis
GEO Series GSE291329. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Top2a Differentially Modulates Promoter Activity in Embryonic Stem Cells via Trim28 Recruitment and PRC2 Displacement [ATAC-Seq]
GEO Series GSE257544. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Snip1 and PRC2 coordinate the intrinsic apoptosis, cell division, and neurogenesis in the developing brain
GEO Series GSE212445. Mus musculus. 80 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.