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7,327 results for “Pathway”
Introduction pathways and evolutionary mechanisms of the spread of alien species of Lolium on sandy coasts in Japan
<p><span>1. Estimating the role of specific processes in the spread of alien species necessitates the d</span><span>etermination of introduction pathways and source populations of invaded areas</span><span>. Alien grasses in the genus <em>Lolium</em> that have become widely invasive in Japan provide provides a unique opportunity to estimate the expansion process through a direct comparison between </span><span>source </span><span>and naturalised populations</span><span> because the </span><span>introduction pathways, contaminants in grain commodities</span><span> and commercial cultivars for fodder crops or revegetation materials are well-known.</span><span> Therefore, by directly comparing between source and naturalised populations, we estimated the introduction pathways and whether adaptative evolution occurred in <em>Lolium</em> species on sandy coasts in Japan.</span></p> <p><span>2. <em>Lolium</em> individuals sampled from naturalised populations in croplands, seaports and sandy coasts were compared with those from two introduction sources for morphological and genetic variations based on a genome-wide single nucleotide polymorphism analysis and a common garden experiment. Furthermore, we conducted a reciprocal sowing experiment between a cropland and sandy coast.</span></p> <p><span>3. Populations naturalized in croplands were closely related to the cultivars, whereas those naturalized in seaports and sandy coasts were associated with contaminants. This pattern is common in western Japan. Therefore, these results indicate that the cropland and sandy coast populations are derived from cultivars and contaminants, respectively. </span><span>The reciprocal transplant experiment clearly demonstrated the home site advantage; populations derived from croplands yielded higher floret numbers than those derived from other habitats at the cropland site; however, such an advantage was not detected with the coastal site population. Sandy coast populations had higher survival rates than those from croplands at coastal sites. Port populations exhibited a similar tendency as sandy coast populations, indicating that contaminants may be originally adapted to salty and dry environments, such as that in sandy coasts.</span></p> <p><span>4. <em>Synthesis</em>. We demonstrated that two congeneric species with different ecological characteristics were introduced through multiple introduction pathways and spread into different habitats</span><span>. </span><span>A direct comparison between </span><span>source </span><span>and naturalised populations </span><span>can greatly advance our understanding of the patterns and processes of biological invasions.</span></p>
Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)
<h2>Data-sets</h2><p>RNAseq_CountTable.tsv: Raw count table from RNA-seq experiments</p><p>WGBS_MethylationTable.tsv: Total read coverage and number of methylated sites at CpG positions (reference genome: hg19) </p><h2>Abstract</h2><p>Chronic lung diseases, including chronic obstructive pulmonary disease (COPD), affect over 500 million people and are a leading cause of death worldwide. A common feature of both chronic and acute lung diseases is altered respiratory barrier integrity and impaired lung regeneration. We hypothesized that alveolar type 2 (AT2) cells, as alveolar epithelial progenitors, will carry molecular alterations that compromise alveolar regeneration in COPD. Sorted AT2 cells from ex-smokers with and without COPD at different disease stages were subjected to RNA sequencing and whole-genome bisulfite sequencing to generate unbiased transcriptome and DNA methylation maps of alveolar progenitors in the lung. Our analysis revealed genome-wide epigenetic changes in AT2 cells during COPD that were associated with global gene expression changes. Integrative data analysis uncovered a strong anti-correlation between gene expression and promoter methylation, suggesting that dysregulation of COPD-associated pathways in AT2 cells may be regulated by DNA methylation. Interferon (IFN) signaling was the top-upregulated pathway associated with the concomitant loss of promoter DNA methylation. Epigenetic regulation of the IFN pathway was validated in both global and targeted DNA demethylation assays in A549 cells. Notably, targeted DNA demethylation of IRF9 triggered upregulation of IFN signaling, mimicking the effects observed in COPD AT2 cells in the profiling data. Our findings suggest that COPD-triggered epigenetic alterations in AT2 cells impair internal regeneration programs in human lung parenchyma.</p>
Model version, input data, results, and processing scripts for Speizer et al., "Rapid implementation of mitigation measures can facilitate decarbonization of the global steel sector in 1.5°C-consistent pathways"
<p>Includes the files needed to run the scenarios, analyze the outputs, and produce the figures for Speizer et al., "Rapid implementation of mitigation measures can facilitate decarbonization of the global steel sector in 1.5°C-consistent pathways." </p>
A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor The
ClinicalTrials.gov study NCT02141282. IPD Sharing: YES. Countries: 1. Publications: 3.
Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced, Metastatic, or Recurrent Triple Negative Invasive Breast Cancer
ClinicalTrials.gov study NCT01151449. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Determine Effect of Enzalutamide (MDV3100) on the Androgen Signaling Pathway in Correlation With the Anti-tumor Effects of Enzalutamide
ClinicalTrials.gov study NCT01091103. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Biobehavioral Pathways Underlying Alcohol Use and Health
ClinicalTrials.gov study NCT05135767. IPD Sharing: YES. Countries: 1. Publications: 0.
Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-Pathway in Metastatic, Recurrent or Primary Unresectable Adrenocortical Cancer
ClinicalTrials.gov study NCT01255137. IPD Sharing: Not stated. Countries: 1. Publications: 3.
My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced S
ClinicalTrials.gov study NCT02091141. IPD Sharing: YES. Countries: 1. Publications: 6.
Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway
ClinicalTrials.gov study NCT02740114. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
ClinicalTrials.gov study NCT02961764. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Accelerated Recovery Pathway for Discharge After Surgery in Patients With Pancreatic Cancer
ClinicalTrials.gov study NCT02517268. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease
ClinicalTrials.gov study NCT01785628. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Symptom Screening Linked to Care Pathways
ClinicalTrials.gov study NCT04614662. IPD Sharing: YES. Countries: 2. Publications: 7.
A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma
ClinicalTrials.gov study NCT00833417. IPD Sharing: Not stated. Countries: 6. Publications: 3.
Angiotensin II Pathway and Postoperative Hypoxemia
ClinicalTrials.gov study NCT05055570. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Practice Facilitation to Enhance Implementation of a Pediatric Suicide Prevention Pathway
ClinicalTrials.gov study NCT06619782. IPD Sharing: YES. Countries: 1. Publications: 1.
Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Tre
ClinicalTrials.gov study NCT03213691. IPD Sharing: Not stated. Countries: 2. Publications: 1.
PROState Pathway Embedded Comparative Trial
ClinicalTrials.gov study NCT04400656. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TMS-fMRI for Neural Pathway in Smokers
ClinicalTrials.gov study NCT02665338. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.