Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
468
datasets available to search
ShareScore release 0.9.0
Dataset results
468 results for “Spikes”
The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2
GEO Series GSE147194. Homo sapiens. 10 samples. Type: Other.
JASPer controls interphase H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila (Spike-in ChIP-seq experiments)
GEO Series GSE130112. Drosophila melanogaster. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
T A B L E 1 in Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS- CoV-2
T A B L E 1 Residues comparison of ACE2 among different species interacting with SARS‐CoV‐2 spike glycoprotein RBD
F I G U R E 3 in Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS- CoV-2
F I G U R E 3 Sequence alignments of the receptor‐binding domain (RBD) of coronavirus spike glycoproteins. The amino acid sequences of RBD of severe respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), pangolin SARS‐like CoV, bat SARS‐like CoV, and SARS‐CoV were aligned. The sequence identities among SARS‐CoV‐2, pangolin SARS‐like CoV SRR10168377, and bat SARS‐like CoV RaTG13 are marked. Arrows show the key residues in the interface binding to ACE2. Arrows indicate the critical binding residues for interaction between coronaviruses spike and receptor, triangle marks the ACE2‐contacting residues on spike RBD. *The unified amino acids in the same sites of all aligned sequences
Data set_Network-wide modulation of synaptic plasticity and spike patterns in motor circuits by pallidal deep brain stimulation in a dystonia model
<p>This study utilized deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) to investigate its long-term effects on synaptic activity in motor thalamic and motor cortical neurons in an animal model of generalized dystonia (dtsz hamster). Whole-cell recordings were employed to measure synaptic spike patterns, revealing significant changes in DBS-treated animals compared to sham-treated controls. Specifically, we observed reduced interspike intervals (ISI) and increased postsynaptic current (PSC) frequencies. Fast oscillations were also detected in both thalamic and motor cortical neurons, indicating potential modulation of corticothalamocortical loops by GPi-DBS. Notably, while the overall discharge rates of spontaneous and evoked action potentials remained unchanged, DBS treatment led to increased PSC amplitudes and alterations in inhibitory synaptic currents. These findings suggest that GPi-DBS influences both presynaptic and postsynaptic mechanisms of synaptic plasticity. The results further indicate that GPi-DBS disrupts desynchronized neural activity through axonal and synaptic failures, thereby reorganizing neuronal firing patterns and synaptic connectivity within the motor circuit. This modulation provides mechanistic insights into the therapeutic effects of GPi-DBS in alleviating dystonic symptoms.</p>
Figure 5 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 5. Manual elements of Draconyx loureiroi holotype ML 357 (ML 357 1-5, 20-26), including articulated partial carpus, manual phalanges and unguals (A–L). Articulated partial carpus (ML 357 – 5) in extensor view (A), right phalanx n.1(ML 357 – 4) in dorsal view (B), lateral view (B1), proximal view (B2) and distal view (B3), left phalanx n.2 (ML 357 – 22) in dorsal view (C), lateral view (C1), proximal view (C2) and distal view (C3), left phalanx n.3 (ML 357 – 21) in dorsal view (D), lateral view (D1), proximal view (D2) and distal view (D3), left phalanx n.4 (ML 357 – 24) in dorsal view (E), lateral view (E1), proximal view (E2) and distal view (E3), isolated distal ends of tarsals (ML 357 – 25,26) in extensor view (F, G), left ungual phalanx n.1 in dorsal view (D), mediolateral view (D1) and proximal view (D2), left ungual phalanx n.1 (ML 357- 1) in dorsal view (H), mediolateral view (H1) and proximal view (H2), right ungual phalanx n.2 (ML 357 – 2) in dorsal view (I), mediolateral view (I1) and proximal view (I2), right ungual phalanx n.3 (ML 357 – 3) in dorsal view (J), mediolateral view (J1) and proximal view (J2), left ungual phalanx n.4 in dorsal view (K), mediolateral view (K1) and proximal view (K2), ungual phalanx n.5 (ML 357 – 20) in dorsal view (L), mediolateral view (L1) and proximal view (L2).
Figure 3 in Reappraisal and new material of the holotype of Draconyx loureiroi (Ornithischia: Iguanodontia) provide insights on the tempo and modo of evolution of thumb-spiked dinosaurs
Figure 3. General overview of Draconyx loureiroi holotype ML 357 post-cranial skeleton. Caudal vertebrae (K-M) in left lateral view. Right femur (A–E) in frontal (A), medial (B), caudal (C), lateral (D) and distal (E) views. Right tibia in medial (F) and lateral (G) views. Proximal end of the fibula in medial (I) and lateral (J) views. Right articulated pes in dorsal (N) and medial (Q) view. Pedal digit III (O) and pedal digit II (P) in dorsal view.
FIGURE 2. Aphelandra almanegra. A. Flowering branch B. Terminal inflorescences showing spikes with fruits and flowers C. Terminal inflorescence with multiple spikes D in Aphelandra almanegra (Acanthaceae), a new species from the dry forests of the Cauca River canyon in Antioquia department, Colombia
FIGURE 2. Aphelandra almanegra. A. Flowering branch B. Terminal inflorescences showing spikes with fruits and flowers C. Terminal inflorescence with multiple spikes D. Close-up view of a flower spike, showing the position of the corolla lobes E. Cross section of an apical branch showing black heartwood F. Much-branched shrubby habit. (Photos of fresh specimens of P. Gallego et al. 1284-HUA).
Spike protein dataset
<p>Spike protein datasets of SARS-CoV-2 variants usend in the article.</p>
FIGURE 9. Piper rubrifolium. A. Sympodial branch with a spike near the apex. B. Fruit lateral view. C in Over- and under-described: new species, new synonyms, and a new name in the megadiverse genus Piper (Piperaceae) on the east Andean slopes
FIGURE 9. Piper rubrifolium. A. Sympodial branch with a spike near the apex. B. Fruit lateral view. C. Detail of the infructescence. D. Floral bract from above. E. Floral diagram. Illustration by Marcela Morales based on the type specimen, W. Trujillo et al. 3139 (COAH).
Variability of Whole Blood Clotting Time Measurements in Ex Vivo Human Blood Samples Spiked With Anticoagulants
ClinicalTrials.gov study NCT03296982. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.
ClinicalTrials.gov study NCT04730895. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling
GEO Series GSE239506. Drosophila melanogaster. 18 samples. Type: Expression profiling by high throughput sequencing.
A ChIP-seq spike-in method enables detection of global histone modification changes across the genome
GEO Series GSE63494. Homo sapiens. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale
GEO Series GSE228009. Caenorhabditis elegans; Homo sapiens; Mus musculus. 110 samples. Type: Expression profiling by high throughput sequencing.
Data from Sustainability Base Characterizing Hot Water Pump Differential Pressure Spikes for ACCEPT
During the heating season in Sustainability Base, a critical alarm associated with a hot water pump circulating heating water for the radiative system which exchanges heat via a geothermal heat pump was found. After further investigation it was ascertained that many such alarms were experienced throughout the entire heating season. These alarms are triggered as a result of the excursion of the hot water differential pressure outside of a nominal operating envelope for a fixed duration. There is a control system associated with regulating the hot water pump differential pressure to a fixed operating setpoint, and there are natural variations in the system that allow the pressure to be regulated and maintained within these nominal operating bounds. However, when system changes occur such as valves opening or closing to support the distribution of hot water through PVC piping to areas of the building where heating demand is called for in response to zone temperature requirements, the pump's operating speed must change accordingly to maintain this setpoint. If the pump speed does not change quickly enough to accommodate heating demand, these alarms can result and consequentially water hammer can occur, which may lead to accelerated aging of the PVC piping infrastructure as well as fittings, elbows, etc. In the worst case scenario it could cause leaking or bursting pipes. The zip file linked contains three subdirectories and a parameter list to be used for processing using ACCEPT. Datafiles are partitioned into training, validation, and testing sub-directory structures. A text file contains all parameter identifiers associated with the cold complaint prediction scenario. Please note that the parameter list is a text file containing the following lines: DCHWSSF - South Wing water flow rate DCHWSNF - North Wing water flow rate DCHWDP - Hot Water Pump Differential Pressure DCHWP1SP - Hot Water Pump Differential Speed DCHWP1S - Hot Water Pump Status Indicator The last parameter in this list is intended only to provide indication of ground truth (pump exceedances), and is not meant to construct models in ACCEPT. Data was collected from November 03, 2014 to February 03, 2015, and the alarm threshold limits of operation are flagged above 6.0 psid and below 4.5 psid. It should be noted the normal operation for the pump includes periods when it is off, when it retains a residual static pressure (~ 1.0 psid). The static binary indicator provides this information.
RR-1 and RR-3 mouse liver transcriptomics with and without ERCC control RNA spike-ins
Proper interpretation of RNA sequencing data requires an understanding of assay sensitivity and sources of variability. To this end, the External RNA Control Consortium (ERCC) developed a standard set of 92 poly-adenylated RNA transcripts that are orthogonal to mammalian RNA that can be added to RNA extracts before library generation and sequencing. The presence of these RNA standards at known ratios improves interpretation of RNA sequencing datasets. To test the utility of the ERCC RNA controls, total RNA extracted from mouse livers from the Rodent Research 1 (flight, ground control, basal control and vivarium control groups) and Rodent Research 3 (flight, ground control and basal control groups) missions were sequenced with and without the ERCC control RNA (RR-3 liver samples without ERCC control have been sequenced previously and the dataset is released in the GLDS-137). To allow comparison within and between groups, ERCC Mix 1 or Mix 2 were added to half of the samples from each group, respectively.
Removing Spikes While Preserving Data and Noise using Wavelet Filter Banks
Many diagnostic datasets suffer from the adverse effects of spikes that are embedded in data and noise. For example, this is true for electrical power system data where the switches, relays, and inverters are major contributors to these effects. Spikes are mostly harmful to the analysis of data in that they throw off real-time detection of abnormal conditions, and classification of faults. Since noise and spikes are mixed together and embedded within the data, removal of the unwanted signals from the data is not always easy and may result in losing the integrity of the information carried by the data. Additionally, in some applications noise and spikes need to be filtered independently. The proposed algorithm is a multi-resolution filtering approach based on Haar wavelets that is capable of removing spikes while incurring insignificant damage to other data. In particular, noise in the data, which is a useful indicator that a sensor is healthy and not stuck, can be preserved using our approach. Presented here is the theoretical background with some examples from a realistic testbed.
Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells
GEO Series GSE220046. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling in young spikes of pistillody wheat line compared with normal wheat line
GEO Series GSE37486. Triticum aestivum. 4 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.