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5,016 results for “THERAPEUTICS”
Therapeutic effect of herbal infusion on Abnormal Uterine Bleeding Extended data
<p>This project contains the following extended data</p> <p> </p>
Salivary Metabolites in Mobile Phone Addicts with Sleep Disorders and Therapeutic Markers of Acupuncture Intervention
<p>Mobile phone addiction (MPA) is a novel behavioral addiction causing diurnal rhythm disorders that severely affect mental and physical health. This work aims to detect rhythmic salivary metabolites in MPA with sleep disorder (MPASD) subjects and probe therapeutic markers for acupuncture intervention. The salivary samples of MPASD and healthy controls were collected at 4 h intervals for three days. Then, MPASD subjects received acupuncture intervention for 7 days, and circadian saliva samples were collected. LC-MS analyzed salivary metabolomes.</p>
Dataset for article: "Massively parallel de novo protein design for targeted therapeutics", DOI: 10.1038/nature23912
<p><strong>"Massively parallel de novo protein design for targeted therapeutics" </strong></p> <p>DOI: 10.1038/nature23912 </p> <p><strong>Supplementary Information</strong>. Archive of designs, Rosetta metrics and experimental results.</p> <p>Authors: <strong>Aaron Chevalier*</strong>, <strong>Daniel-Adriano Silva*</strong>, <strong>Gabriel J. Rocklin*</strong>, Derrick R. Hicks, Renan Vergara, Patience Murapa, Steffen M. Bernard, Lu Zhang, Kwok-ho Lam, Guorui Yao, Christopher D. Bahl, Shin-ichiro Miyashita, Inna Goreshnik, James T. Fuller, Merika T. Koday, Cody Jenkins, Tom Colvin, Lauren Carter, Alan Bohn, Cassie M. Bryan, D. Alejandro Fernández-Velasco, Lance Stewart, Min Dong, Xuhui huang, Rongsheng Jin, Ian A. Wilson, Deborah H. Fuller & <strong>David Baker</strong></p> <p><strong>*These authors contributed equally to this work</strong>.</p> <p>Correspondence to: dabaker@uw.edu</p> <p>Dataset Compiled by D-A.S.</p> <p>Date: 13/Sep/2017</p>
Therapeutic working alliance in brief therapy with college students: In-person versus telemental health
<p>This study compared the therapeutic working alliance in brief counseling using two delivery methods: synchronous video delivery and in-person delivery. The alliance was measured using the Working Alliance Inventory (client version). Participants were 49 undergraduate college students between the ages of 18 and 22. Solution-Focused Brief Therapy was the treatment protocol, and the study used a randomized, controlled design. Welch's t-tests and non-inferiority analyses were conducted, in addition to hierarchical regression analyses to examine the predictive value of the working alliance on post-treatment anxiety. Non-inferiority statistical analyses indicated that there was no statistically significant difference in working alliance for online delivery compared to in-person. A hierarchical regression anaIysis suggests that the therapeutic working alliance contributed to anxiety treatment outcomes for college student participants.</p>
Supplemental files associated with the the manuscript "Genetic screening and metabolomics identify glial adenosine metabolism as a therapeutic target in Parkinson's disease"
Open the record for dataset details and reuse information.
Kroll et al., 2024. Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes
<p>Data repository for</p> <p>François Kroll, Joshua Donnelly, Joshua Donnelly, Güliz Gürel Özcan, Eirinn Mackay, Jason Rihel</p> <div> <div><strong>Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes</strong></div> <br> <div>eLife, 2024.</div> <br> <div><a href="https://doi.org/10.7554/eLife.96839.1">https://doi.org/10.7554/eLife.96839.1</a></div> <div> </div> <div>Code is found in the <a href="https://github.com/francoiskroll/ZFAD">GitHub repository</a>. Please see notes there.</div> </div> <p>___</p> <p>Contact:</p> <p>Twitter: @francois_kroll</p> <p>Email: francois@kroll.be</p>
Therapeutic body wrap video demo
<p> This10-minute-video presents video clips of the same child during several TBW sessions both at session<br> beginnings and session endings. This video is related to Delion et al. manuscript published in PlosONE and entitled "Therapeutic body wraps (TBW) for treatment of severe injurious behaviour in children with autism spectrum disorder (ASD): a 3-month randomized controlled feasibility study".</p> <p>The detailed clinical history of this child has been reported in Cravero C, Guinchat V, Xavier J, Meunier C, Diaz L, Mignot C, Doummar D, Chantot-Bastaraud S, Consoli A, Cohen D. Management of severe developmental regression in an autistic child with a 1q21.3 microdeletion and self-injurious blindness. Case Rep Psychiatry 2017; 2017: e7582780. https://doi.org/10.1155/2017/7582780</p>
Dataset used in "Deamidation analysis of Therapeutic Drugs using Matrix-assisted Laser Desorption Ionization Mass Spectrometry and A Novel Algorithm QuanDA"
<p><span>Overview</span></p> <p><span>Theoretical MALDI spectra of peptides, both before and after deamidation, are crucial for the analysis of real samples. QuanDA is a method utilizing non-negative least squares to calculate the percentage of deamidation during the aging process of standard peptides and therapeutic drugs.</span></p> <p><span>Dataset Description</span></p> <p><span>The `data` directory contains example datasets specifically designed for analyzing peptide deamidation:</span></p> <p><span>D.txt: Simulated spectra of the pure synthetic peptide Pep-D.</span></p> <p><span>N.txt: Simulated spectra of the pure synthetic peptide Pep-N.</span></p> <p><span>Asn2Asp18: Contains 10 measurements from a sample comprising 10% Pep-N and 90% Pep-D.</span></p> <p><span>Asn18Asp2: Comprises 10 measurements from a sample with 90% Pep-N and 10% Pep-D.</span></p> <p><span>Peptide Sequences: Pep-N: YTHQGLSSPVTKSFNRGE; Pep-D: YTHQGLSSPVTKSFDRGE</span></p> <p><span>These synthetic peptides are utilized to investigate deamidation behavior.</span></p> <p><span>Somatostatin Dataset: Contains data from actual samples analyzed over 0-13 days under physiological conditions (pH 7.4, 37°C) and storage conditions (pH 4, 4°C). This dataset includes theoretical values before and after deamidation.</span></p>
Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
<p>Data underlying the figures in the publication “Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming”, published in <em>Nat Commun</em>, <strong>2020</strong>, 11, 608. <a href="https://www.nature.com/articles/s41467-020-14397-8">https://www.nature.com/articles/s41467-020-14397-8</a></p> <p>Table of contents:</p> <p><strong>1. Source Data</strong>; Excel file with the data for <em>Figures 2, 3b, 3d, 3c, 4a, 4b, 4c, 5</em> as well as <em>S2, S3, S4, S5, S6, S7a, S7b, S8, S9, S10, S11, S12, S13a</em> and <em>S13b</em>.</p> <p><strong>Data 1 – Transgene expression by SEAP</strong></p> <p>Data for <em>Figures 2, S2, S4, S5, S7a, S8, S9, S12</em> and <em>S13b</em>.</p> <p>SEAP (human placental secreted alkaline phosphatase) levels were profiled in cell culture supernatants using a colorimetric assay. 100 µL 2x SEAP assay buffer (20 mM homoarginine, 1 mM MgCl2, 21% diethanolamine, pH 9.8) was mixed with 80 µL heat-inactivated (30 min at 65 °C) cell culture supernatant. After the addition of 20 µL substrate solution (120 mM p-nitrophenyl phosphate; cat. no. AC128860100, Thermo Fisher Scientific, Waltham, MA, USA), the absorbance time course was recorded at 405 nm and 37 °C using a Tecan Genios PRO plate reader (cat. no. P97084; Tecan Group AG, Maennedorf, Switzerland) and the SEAP levels were determined as follows: first, absorbance change over time (slope) was calculated. According to the Beer–Lambert’s law, absorbance is proportional to the concentration of a colored compound and depends on the light path length (d) and extinction coefficient (ε) (ε for p-nitrophenyl (εpNP) = 18.600 M−1 cm−1). Enzymatic activity EA [U/L] was calculated from the equation: EA = slope × dilution factor × εpNP−1 × d−1</p> <p>Values in the file present determined SEAP levels.</p> <p><strong>Data 2 – Endogenous gene expression by qPCR</strong></p> <p>Data for <em>Figures 3b, 3d, 4a, 4b, 5, S3, S6, S10, S11</em> and <em>S13a</em>.</p> <p>Total RNA of HEK293T cells was isolated using the Quick-RNA kit (Zymo Research, Irvine, CA, USA). Reverse transcription was performed using a High-Capacity cDNA Reverse Transcription Kit (cat. no. 4368814, Thermo Fisher Scientific, Waltham, MA, USA). Quantitative PCR was performed with the SsoAdvanced Universal SYBR® Green Supermix (cat. no. 1725270, Bio-Rad, Hercules, CA, USA). The Eppendorf Realplex Mastercycler (Eppendorf GmbH) was set to the following amplification parameters: 30 s at 95 °C and 40 cycles of 15 s at 95 °C followed by 30 s at X °C (X = 59 for insulin, 64 for IL-12, 59 or 64 for GAPDH). The relative threshold cycle (Ct) was determined and normalized to the endogenous glyceraldehyde 3-phosphate dehydrogenase (GAPDH) transcript. The fold change for each transcript relative to the control was calculated using the comparative Ct method.</p> <p>Values in the file present determined mRNA levels relative to GAPDH.</p> <p><strong>Data 3 – Secreted protein level by ELISA</strong></p> <p>Data for <em>Figures 3c</em> and <em>4c</em>.</p> <p>Human Insulin was quantified with the Mercodia Insulin ELISA (cat. no. 10-1113-01, Mercodia, Uppsala, Sweden). IL-12 was quantified with the human IL-12 (p40) ELISA Kit (cat. no. KAC1561, Thermo Fisher Scientific, Waltham, MA, USA).</p> <p>Values in the file present protein levels as determined by ELISA kit.</p> <p><strong>Data 4 – Nanoluc luciferase</strong></p> <p>Data for <em>Figure S7b</em>.</p> <p>NanoLuc® luciferase was quantified in cell culture supernatants using the Nano-Glo® Luciferase Assay System (cat. no. N1110; Promega, Duebendorf, Switzerland). In brief, 7.5 µL of cell culture supernatant was added per well of a black 384-well plate and mixed with 7.5 µL substrate-containing assay buffer. Total luminescence was quantified using a Tecan Genios PRO plate reader (Tecan Group AG).</p> <p>Values in the file present luminescence as measured.</p>
Smart-Watch-Programmed Green-Light-Operated Percutaneous Control of Therapeutic Transgenes
<p>Data underlying the figures in the publication “Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes”, published in <em>Nat. Commun.</em>, <strong>2021</strong>, 12, 3388.</p> <p><a href="https://doi.org/10.1038/s41467-021-23572-4">https://doi.org/10.1038/s41467-021-23572-4</a></p> <p>Table of contents:</p> <p><strong>1. Dataset</strong>; Excel file containing the numerical data for <em>Figures 1c, 2b, 2c, 3a-f, 4a, 4c, 5b, 5d, 6b-h </em>as well as for<em> Figures S1C, S3a-c, S4, S5b, S6b, S7c, S8b, S12c, S13b, S14 </em>and <em>S15b-d.</em></p> <p> </p> <p> </p>
Activation of Therapeutic Nucleic Acids from a Mechanoresponsive Drug Carrier by Low-intensity Imaging Ultrasound
<p>Data sets used for main figures of the manuscript entitled 'Activation of Therapeutic Nucleic Acids from a Mechanoresponsive Drug Carrier by Low-intensity Imaging Ultrasound'.</p>
Mammalian animal & human retinal organ culture as pre-clinical model to evaluate oxidative stress and antioxidant intraocular therapeutics
<p>Oxidative stress (OS) is involved in the pathogenesis of retinal neurodegenerative diseases like age-related macular degeneration (AMD) and diabetic retinopathy (DR) and an important target of therapeutic treatments. New therapeutics are tested in vivo despite limits in transferability and ethical concerns. Retina cultures using human tissue can deliver critical information and significantly reduce the number of animal experiments along with increased transferability. We cultured up to 32 retina samples derived from one eye, analyzed models’ quality, induced OS, and tested efficiency of antioxidative therapeutics. Bovine, porcine, rat, and human retinae were cultured in different experimental settings for 3-14 d. OS was induced by high-glucose or hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and treated by Scutellarin, pigment epithelium-derived factor (PEDF), and/or granulocyte macrophage-colony stimulating factor (GM-CSF). Tissue morphology, cell viability, inflammation, and glutathione level were determined. Retina samples showed only moderate necrosis (23.83±5.05 increased to 27.00±1.66 AU PI-staining over 14 d) after 14 days in culture. OS was successfully induced (reduced ATP content of 288.3±59.9 vs. 435.7±166.8 nM ATP in controls); antioxidants reduced OS-induced apoptosis (from 124.20±51.09 to 60.80±319.66 cells/image after Scutellarin-treatment). Enhanced mammalian animal and human retina cultures allow reliable, highly transferable research on OS-triggered age-related diseases and pre-clinical testing during drug development.</p>
Fig. 1. Figure showing the 2D in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 1. Figure showing the 2D structural representation of lemongrass oil components (A–H). Component structures taken from Pubchem database.
Fig. 3 in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 3. Pharmacophores of ligands H-bond interactions with receptor binding amino acid residues of human HSP90-ATPase binding with (A) ADP; (B) Geldanamycin; (C) Geraniol; (D) Citral; (E) Geranyl Acetate; (F) Methyl Eugenol; (G) Myrcene; (H) Elemicin.
Fig. 2 in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 2. Docking scores of all screened ligands with HSP90 protein of humans (A), P. falciparum (B) and S. cerevisiae (C) which are showing the minimum free binding affinity (ΔG = kcal/mol).
Association between a glucagon-like peptide 1 receptor genetic polymorphism and therapeutic response to sitagliptin in a sample of type 2 diabetic patients: an observational study
<p>Association between a glucagon-like peptide 1 receptor genetic polymorphism and therapeutic response to sitagliptin in a sample of type 2 diabetic patients: an observational study</p>
Comprehensive analysis of the cuproptosis-related gene glutaminase across cancers: a potential prognostic therapeutic target for gliomas
<p><strong>Supplementary Table S1</strong> Clinical information of glioma patients.</p> <p><strong>Supplementary Table S2</strong> Top 100 genes associated with GLS.</p> <p><strong>Supplementary Table S3</strong> GO enrichment analysis data for GLS-associated genes.</p> <p><strong>Supplementary Table S4</strong> KEGG enrichment analysis data for GLS-associated genes.</p> <p><strong>Supplementary Table S5</strong> Antineoplastic drugs significantly associated with GLS.</p>
The Therapeutical Role of Continuous Intra-femoral Artery Infusion of Urokinase on Diabetic Foot Ulcers
ClinicalTrials.gov study NCT01108120. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Trial of n-3 PUFA-Enriched Ready to Use Therapeutic Food for Childhood Severe Malnutrition
ClinicalTrials.gov study NCT01593969. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessment Of Disease Pathology And Key Therapeutic Targets In Severe Asthma
ClinicalTrials.gov study NCT00327197. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.