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606
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Dataset results
606 results for “association genetics”
Deciphering the genetic regulation of peripheral blood transcriptome in pigs through allele-specific expression analysis and expression genome-wide association study
GEO Series GSE97374. Sus scrofa. 243 samples. Type: Expression profiling by array.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [scDNA-seq_MOI]
GEO Series GSE231543. Mus musculus. 5 samples. Type: Other.
Hypomethylation mediates genetic association with the major histocompatibility complex genes in Sjögren's syndrome
GEO Series GSE166373. Homo sapiens. 131 samples. Type: Methylation profiling by array.
A study of genetic variants associated with skin traits in the Vietnamese population
GEO Series GSE248483. Homo sapiens. 96 samples. Type: SNP genotyping by SNP array.
Systems biology demonstrates the predominant role of circulating interferon-alpha in primary Sjögren's syndrome and a genetic association with the class II HLA DQ locus
GEO Series GSE140161. Homo sapiens. 351 samples. Type: Expression profiling by array.
Comparison of Cancer-Associated Genetic Abnormalities in Columnar-Lined Esophagus with and without Goblet Cells
GEO Series GSE40769. Homo sapiens. 57 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
A quantitative chemotherapy genetic interaction map identifies new factors associated with PARP inhibitor resistance
GEO Series GSE101904. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [DNA-seq_distribution]
GEO Series GSE231542. Mus musculus. 2 samples. Type: Other.
Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [RNA-Seq]
GEO Series GSE172367. Homo sapiens. 190 samples. Type: Expression profiling by high throughput sequencing.
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target [DNA_methylation_array]
GEO Series GSE260660. Mus musculus. 46 samples. Type: Methylation profiling by genome tiling array.
Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer cell lines and isogenic models [isogenic models]
GEO Series GSE274006. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
Data from: An association between differential expression and genetic divergence in the Patagonian olive mouse (Abrothrix olivacea)
Recent molecular studies have found striking differences between desert-adapted species and model mammals regarding water conservation. In particular, aquaporin 4, a classical gene involved in water regulation of model species, is absent or not expressed in the kidneys of desert-adapted species. To further understand the molecular response to water availability we studied the Patagonian olive mouse Abrothrix olivacea, a species with an unusually broad ecological tolerance that exhibits a great urine concentration capability. The species is able to occupy both the arid Patagonian steppe and the Valdivian and Magellanic forests. We sampled 95 olive mouse specimens from four localities (two in the steppe, two in the forests) and analyzed both phenotypic variables and transcriptomic data to investigate the response of this species to the contrasting environmental conditions. The relative size of the kidney and the ratio of urine to plasma concentrations were, as expected, negatively correlated with annual rainfall. Expression analyses uncovered nearly 3,000 genes that were differentially expressed between steppe and forest samples and indicated that this species resorts to the "classical" gene pathways for water regulation. Differential expression across biomes also involves genes involved in immune and detoxification functions. Overall, genes that were differentially expressed showed a slight tendency to be more divergent and to display an excess of intermediate allele frequencies, relative to the remaining loci. Our results indicate that both differential expression in pathways involved in water conservation and geographical allelic variation are important in the occupation of contrasting habitats by the Patagonian olive mouse.
Figure 4 from: Al-Musawi ZJMA, Al-Juhaishi AMR (2024) Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e111984
Figure 4 The PANSS score of schizophrenic and healthy volunteers.
Figure 2 from: Al-Musawi ZJMA, Al-Juhaishi AMR (2024) Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e111984
Figure 2 The Prevalence of D2 receptor alleles A-241G (rs1799978) among volunteers.
Figure 1 from: Al-Musawi ZJMA, Al-Juhaishi AMR (2024) Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e111984
Figure 1 Genotyping of D2 receptor genes A-241G (rs1799978).
Mild behavioral impairment in early Alzheimer's disease and its association with APOE and BDNF risk genetic polymorphisms
<p>Mild behavioral impairment (MBI) has been commonly reported in early Alzheimer’s disease (AD) but rarely using biomarker-defined samples. It is also unclear whether genetic polymorphisms influence MBI in such individuals. We thus aimed to examine the association between the cognitive status of participants (amnestic mild cognitive impairment (aMCI-AD) vs cognitively normal (CN) older adults) and MBI severity. Within aMCI-AD, we further examined the association between APOE and BDNF risk genetic polymorphisms and MBI severity.</p> <p>We included 62 aMCI-AD participants and 50 CN older adults from the Czech Brain Aging Study. The participants underwent neurological, comprehensive neuropsychological examination, APOE and BDNF genotyping, and magnetic resonance imaging. MBI was diagnosed with the Mild Behavioral Impairment Checklist (MBI-C), and the diagnosis was based on the MBI-C total score ≥ 7. Additionally, self-report instruments for anxiety (the Beck Anxiety Inventory) and depressive symptoms (the Geriatric Depression Scale-15) were administered. The participants were stratified based on the presence of at least one risk allele in genes for APOE (i.e., e4 carriers and non-carriers) and BDNF (i.e., Met carriers and non-carriers). We used linear regressions to examine the associations.</p> <p>MBI was present in 48.4% of the aMCI-AD individuals. Compared to the CN, aMCI-AD was associated with more affective, apathy, and impulse dyscontrol but not social inappropriateness or psychotic symptoms. Furthermore, aMCI-AD was related to more depressive but not anxiety symptoms on self-report measures. Within the aMCI-AD, there were no associations between <em>APOE</em> e4 and <em>BDNF</em> Met and MBI-C severity. However, a positive association between Met carriership and self-reported anxiety appeared.</p> <p>MBI is frequent in aMCI-AD and related to more severe affective, apathy, and impulse dyscontrol symptoms. <em>APOE</em> and <em>BDNF</em> polymorphisms were not associated with MBI severity separately; however, their combined effect warrants further investigation.</p>
Genetic Associations with Learning Over 100 Days of Practice
<p>Code Availability for Genetic Associations with Learning Over 100 Days of Practice</p>
Supplementary Figure S1 The scatter plots of the association between genetically predicted in the reverse MR analysis
<p>This figure described the scatter plots of the association between genetically predicted in the reverse MR analysis.</p>
Identification of genetic markers associated with clinical response of ketose treatment in Holstein cows
<p><strong>Additional File</strong> <strong>1</strong>- <strong>Table S1.</strong> Mean and standard deviations of blood BHB concentration (mmol/L) for groups of cows classified as Chronic, Cured, Recurrent, and Severe considering their responses to the administration of propylene glycol and 50% dextrose to control hyperketonemia between 1st and 4nd week of lactation.</p> <p><strong>Additional File</strong> <strong>2</strong>- <strong>Spreadsheet S1.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Cured vs Resistant contrast, <strong>Spreadsheet S2.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Severe vs Resistant contrast. <strong>Spreadsheet S3.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Chronic vs Resistant contrast,<strong> Spreadsheet S4.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Recurrent vs Resistant contrast.<strong> </strong></p> <p><strong>Additional File</strong> <strong>3</strong>-<strong> Spreadsheet S1. </strong>Pathways associated with genes identified to Cured vs Resitant contrast, <strong>Spreadsheet S2. </strong>Pathways associated with genes identified to Severe vs Resitant contrast,<strong> Spreadsheet S3. </strong>Pathways associated with genes identified to Chronic vs Resitant contrast,<strong> Spreadsheet S4. </strong>Pathways associated with genes identified to Recurrent vs Resitant contrast,<strong> Spreadsheet S6.</strong> Pathways associated with genes set identified among 4 analyzed contrasts (Cured, Severe, Chronic and Recurrent compared with Resistant, respectively), <strong>Spreadsheet S7.</strong> Protein Interaction network associated with genes set identified among 4 analyzed contrasts (Cured, Severe, Chronic and Recurrent compared with Resistant, respectively).</p> <p><strong>Additional File</strong> <strong>4</strong>- <strong>Spreadsheet S1.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Cured vs Resistant contrast analysis, <strong>Spreadsheet S2.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Severe vs Resistant contrast, <strong>Spreadsheet S3.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Chronic vs Resistant contrast, <strong>Spreadsheet S4.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Recurrent vs Resistant contrast.</p>
Association of Genetic Polymorphisms With Capecitabine-based Chemotherapy Toxicities in Chinese Solid Tumor Patients
ClinicalTrials.gov study NCT03258099. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.