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Dataset results
671 results for “mediating effect”
Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects [ChIP-seq]
GEO Series GSE108344. Mus musculus. 59 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons
GEO Series GSE233226. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
NF-κB- and TET2-mediated macrophage reprogramming overrides the anti-inflammatory effects of hypoxia and improves responses in human cancer (DNA methylation I).
GEO Series GSE261317. Homo sapiens. 20 samples. Type: Methylation profiling by array.
Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin A in HEK293 cells treated with TNF-alpha I
GEO Series GSE101626. Homo sapiens. 16 samples. Type: Expression profiling by array.
NF-κB- and TET2-mediated macrophage reprogramming overrides the anti-inflammatory effects of hypoxia and improves responses in human cancer (RNA-Seq II).
GEO Series GSE261323. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Glial immune-related pathways as mediators of closed head TBI effects on behavior and lethality in Drosophila
GEO Series GSE164377. Drosophila melanogaster. 17 samples. Type: Expression profiling by high throughput sequencing.
KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA Polymerase II- and III-mediated expression
GEO Series GSE106976. Mus musculus. 21 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin B in HCT116 cells treated with or without TNF-alpha
GEO Series GSE101628. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Effect of sgRNA-mediated disruption of GLUT1 on gene expression on c-Kit+ MLL::AF9 leukemia cells
GEO Series GSE209636. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effect of siRNA mediated silencing of lncRNA NRCP in cancer cells
GEO Series GSE74447. Homo sapiens. 6 samples. Type: Expression profiling by array.
Effect of loss of function of Gal11/Med15 and Med3 from the Mediator tail module in budding yeast
GEO Series GSE31774. Schizosaccharomyces pombe; Saccharomyces cerevisiae. 21 samples. Type: Expression profiling by array.
Effect of RNAi-mediated knockdown of cac on gene expression in motor neurons of Drosophila melanogaster third instar larva
GEO Series GSE301255. Drosophila melanogaster. 9 samples. Type: Expression profiling by high throughput sequencing.
Effect of MOF mediated UHRF1 acetylation on global DNA methyaltion maintenance in mouse embryonic stem cells.
GEO Series GSE225947. Mus musculus. 7 samples. Type: Methylation profiling by high throughput sequencing.
Microarray analysis of the effect of shRNA-mediated HAVCR2 knock-down (KD) in TIM-3-positive AML cell line, KASUMI-3
GEO Series GSE130328. Homo sapiens. 6 samples. Type: Expression profiling by array.
Plant-mediated effects of an entomovirus on growth and two enzymes of caterpillars
<p>Data for the paper "Plant-mediated effects of an entomovirus on growth and two enzymes of caterpillars".</p>
Data from: Small mammal herbivores mediate the effects of soil nitrogen and invertebrate herbivores on grassland diversity
1. Simultaneous reductions in herbivore abundance and increases in nitrogen deposition have led to radical shifts in plant communities worldwide. While the individual impacts of these human-caused disturbances are apparent, few studies manipulate both herbivory and N, nor differentiate among herbivore guilds, to understand contingencies in the ability of these drivers to affect producer diversity and productivity. As such, understanding how the main and combined effects of increasing soil N with declining herbivores may influence plant community structure and function is critical to better understand the future of grassland ecosystems under multiple global change drivers. 2. In this study, we asked: (1) What are the main effects of small mammal herbivores, invertebrate herbivores, and soil N on plant community structure and function? and (2) Are the effects of invertebrate herbivores and soil N on plant community structure and function contingent on small mammal herbivory? We used a design, with invertebrate and soil N treatments nested within small mammal manipulations in an existing tall grass prairie. We quantified plant community structure ( plant richness, evenness, diversity, and composition). We also recorded total aboveground biomass to quantify grassland productivity. 3. We found that small mammal herbivores strongly shaped plant diversity, species composition, and productivity. Small mammal herbivores also mediated the effects of soil N and invertebrate herbivores on grassland community structure, but not composition or productivity. Small mammal reduction lowered plant species richness while increasing above ground biomass and altering compositional similarity. Invertebrate herbivores, in the presence of small mammals, promoted plant dominance by reducing evenness without altering compositional similarity. Additionally, soil nitrogen addition reduced plant richness, but only when small mammals were reduced, and no effects on compositional similarity or productivity. 4. Our findings provide further evidence that temperate grasslands productivity and diversity are driven by top and bottom up factors.
Data from: Phenotypic plasticity in female mate choice behavior is mediated by an interaction of direct and indirect genetic effects in Drosophila melanogaster
Female mate choice is a complex decision-making process that involves many context-dependent factors. In Drosophila melanogaster, a model species for the study of sexual selection, indirect genetic effects (IGEs) of general social interactions can influence female mate choice behaviors, but the potential impacts of IGEs associated with mating experiences are poorly understood. Here, we examined whether the IGEs associated with a previous mating experience had an effect on subsequent female mate choice behaviors and quantified the degree of additive genetic variation associated with this effect. Females from 21 different genetic backgrounds were housed with males from one of two distinct genetic backgrounds for either a short (3 hr) or long (48 hr) exposure period and their subsequent mate choice behaviors were scored. We found that the genetic identity of a previous mate significantly influenced a female's subsequent interest in males and preference of males. Additionally, a hemiclonal analysis revealed significant additive genetic variation associated with experience-dependent mate choice behaviors, indicating a genotype-by-environment interaction for both of these parameters. We discuss the significance of these results with regard to the evolution of plasticity in female mate choice behaviors and the maintenance of variation in harmful male traits.
A Mediation Model of the Usability and Intergroup Relation for Online Project Management Community Effectiveness with Microsoft Teams
<p>A Mediation Model of the Usability and Intergroup Relation for Online Project Management Community Effectiveness with Microsoft Teams</p>
Data for Cortese et al. (2024). Environmental change mediates plasticity in offspring traits through maternal effects in a coral reef fish. STOTEN
<p>Data used for producing figures and result of the publication <em><span>Cortese et al. (2024). </span><span>Environmental change mediates plasticity in offspring traits through maternal effects in a coral reef fish.</span></em><span> <em>STOTEN.</em></span></p> <p> </p>
Species specific plant-mediated effects between herbivores converge at high damage intensity
<p>Plants are often exposed to multiple herbivores and densities of these attackers (or corresponding damage intensities) generally fluctuate greatly in the field. Plant-mediated interactions vary among herbivore species and with changing feeding intensity, but little is known about how herbivore identity and density interact to determine plant responses and herbivore fitness. Here, we investigated this question using <i>Triadica sebifera </i>(tallow) and its two major specialist insect herbivores, <i>Bikasha collaris</i> (flea beetle) and <i>Heterapoderopsis bicallosicollis</i> (weevil). By manipulating densities of leaf-feeding adults of these two insects, we tested how variations in the intensity of leaf damage caused by flea beetle or weevil adults affected the performance of root-feeding flea beetle larvae and evaluated the potential of changed traits of tallow root as predictions of flea beetle larval performance. We found that weevil adults consistently decreased the survival of flea beetle larvae with increasing leaf damage intensities. In contrast, conspecific flea beetle adults increased their larval survival at low damage then decreased larval survival at high damage, resulting in a unimodal pattern. Chemical analyses showed that increasing leaf damage from weevil adults linearly decreased root carbohydrates and increased root tannin, whereas flea beetle adults had opposite effects as weevil adults at low damage and similar effects as them at high damage. Furthermore, across all feeding treatments, flea beetle larval survival was positively correlated with concentrations of carbohydrates and negatively correlated with concentration of tannin, suggesting that root primary and secondary metabolism might underlie observed effects on flea beetle larvae. Our study demonstrates that herbivore identity and density interact to determine systemic plant responses and plant-mediated effects on herbivores. In particular, effects are species specific at low densities, but converge at high densities. These findings emphasize the importance of considering herbivore identity and density simultaneously when identifying factors driving plant-mediated interactions between herbivores, advancing our understanding of the structure and composition of herbivore communities and terrestrial food-webs.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.