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2,216 results for “membrane”
Harnessing Pore Size in COF Membranes: A Concentration Gradient-Driven Molecular Dynamics (CGD-MD) Study on Enhanced H₂/CH₄ Separation
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Supporting data and analytical codes for membrane tomography study
<p>Datasets (tilt series, tilt angles, EELS maps, reference reconstructions) for membrane tomography. Reconstruction codes not currently packaged, but analytical methods for the EELS and density calculations are. </p>
Time-resolved reflectometry on free-standing membranes of SrRuO3
<div> <div>The data in this repository involve time-resolved reflectivity measurements on crystals of nanometric thickness. We use nanoscale acoustic confinement to excite coherent acoustic phonons (dynamical strain) with near-terahertz frequency, and demonstrate that such phonons can easily be excited when breaking the film-substrate epitaxy in the metallic perovskite SrRuO3. Moreover, thermal annealing of the free-standing membranes placed on a substrate with a similar lattice constant dramatically decreases the interfacial acoustic impedance mismatch, evidencing the reformation of chemical bonds and interfacial restructuring.</div> </div>
Free Energy of Membrane Pore Formation and Stability from Molecular Dynamics Simulations
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Computational dataset, scripts and models for 'Lipid shape as a membrane activity modulator of a model antimicrobial peptide'
<p>Analysis scripts and computational models used in the manuscript 'Lipid shape as a membrane activity modulator of a model antimicrobial peptide', by Marcin Makowski, Octávio L. Franco, Nuno C. Santos and Manuel N. Melo.</p>
Data for 'Membrane marker selection for segmenting single cell spatial proteomics data'
<p>Additional data for 'Membrane marker selection for segmenting single cell spatial proteomics data'</p>
Data for "Electrically Controlling and Optically Observing the Membrane Potential of Supported Lipid Bilayers"
<p>Raw data of all EIS, imaging and time-resolved fluorescence measurements presented in "Electrically Controlling and Optically Observing the Membrane Potential of Supported Lipid Bilayers".</p>
Data Used for Article "Imaging and spectroscopyof domains of the cellular membrane by photothermal-induced resonance"
<p>PTIR data collected from buccal cells.</p> <p>Used in article by L. Quaroni "Imaging and spectroscopy of domains of the cellular membrane by photothermal-induced resonance"</p> <p><em><strong>Analyst</strong></em>, 2020,<strong>145</strong>, 5940-5950 ; doi.org/10.1039/D0AN00696C</p>
Supplementary datasets from: The wettability of electron spun membranes by synovial fluid
<p>Aseptic loosening due to periprosthetic osteolysis has been accepted as one of the leading causes of revision procedures in patients with previous joint arthroplasty. Recently, several strategies for suppression of osteolysis were proposed, mostly based on biological treatment such as mitigation of chronic inflammatory reactions. However, these biological treatments do not stop the debris migration but only reduce the inflammatory reaction. To address this shortcoming, we propose the concept of ultrahigh molecular weighted polyethylene (UHMWPE) particles filtration-storage by electrospun membranes. Firstly, the surface tension of synovial fluid is obtained by use of a pendant droplet. Secondly, the contact angle of the electrospun membranes wetted by two different liquids is measured to obtain the free surface energy using of the Owens-Wendt model. Additionally, the wettability of electrospun membranes by synovial fluid as a function of technology parameters is studied.</p>
Mitochondrial and ER membrane protein trafficking CRISPR screens
<p><span>The trafficking of specific protein cohorts to the correct subcellular location at the correct time is essential for every signaling and regulatory process in biology. Gene perturbation screens could provide a powerful approach to probe the molecular mechanisms of protein trafficking, but only if protein localization or mislocalization can be tied to a simple and robust phenotype for cell selection, such as cell proliferation or FACS. To broadly empower the study of protein trafficking processes with gene perturbation, we developed a genetically-encoded molecular tool named HiLITR. HiLITR converts protein colocalization into proteolytic release of a membrane-anchored transcription factor, which drives the expression of a chosen reporter gene. Using HiLITR in combination with FACS-based CRISPRi screening in human cell lines, we identify genes that influence the trafficking of mitochondrial and ER tail-anchored proteins. </span>We show that loss of the SUMO E1 component SAE1 results in the mislocalization and destabilization of mitochondrial tail-anchored proteins. We also demonstrate a distinct regulatory role for EMC10 in the ER membrane complex, opposing the transmembrane-domain insertion activity of the complex. Through transcriptional integration of complex cellular functions, HiLITR expands the scope of biological processes that can be studied by genetic perturbation screening technologies.</p>
Data from: Quantum Membrane Accelerometer Microchip
<p>Source data for figures.</p>
Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease
<p><span><strong>Background:</strong> </span><span>The loss of E-cadherin expression and the induction of N-cadherin are known as hallmarks of the epithelial-to-mesenchymal transition, an essential initial step in the process of metastasis in solid tumors. Although several studies have reported expressions of these cadherins in patients with multiple myeloma (MM), their clinical significance is unknown as MM cells are non-epithelial. </span></p> <p><strong><span>Methods:</span></strong><span> In this study, we examined the expression of E- and N-cadherins by immunohistochemistry using bone marrow (BM) biopsy specimens from 31 newly diagnosed MM patients and in subsequent biopsy specimens from six of these. </span></p> <p><strong><span>Results:</span></strong><span> Negative E-cadherin expression on BM myeloma cell membranes was significantly associated with the presence of soft-tissue masses arising from bone lesions and breaking through the cortical bone, referred to as extramedullary disease (EMD).</span></p> <p><strong><span>Conclusions:</span></strong><span><strong> </strong>Given the aggressive nature of EMD, our study suggests that screening for E-cadherin using BM immunohistochemistry is one measure that could predict the development of EMD in patients with MM.</span></p>
Source data for "High-κ perovskite membranes as insulators for two-dimensional transistors"
<p>IMPORTANT: The data must not be reused in other studies or publications without the approval of the corresponding authors. Additional data related to this paper may be requested from the corresponding authors upon reasonable request.</p>
Raw gel and membrane figures associated with the publication "Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells"
<p>Raw gel and membrane figures associated with the publication <strong>Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells</strong>.</p> <p> </p> <p><strong>For Figure 1a:</strong></p> <p>Raw uncropped image of the gel run with samples combining apotransferrin with iron chelators. After staining with Coomassie, gel was scanned in an Epson V500 scanner (full color, 1200 dpi, bit depth = 24).</p> <p> </p> <p><strong>For Figure 3:</strong></p> <p>Raw uncropped images of the membranes obtained from western blots of cultured erythroblasts derived from three different donors, showing the expression level of proteins involved in iron metabolism regulation (ferritin, transferrin receptor, total EIF2, phospho-EIF2). Actin was used as housekeeping protein for relative quantification of protein abundance for further analysis.</p> <p>After staining, membranes were scanned in an Epson V500 scanner (full color, 1200 dpi, bit depth = 24).</p> <p>For all membranes, the loading order is the same:</p> <p>- <strong>Day 0:</strong> 1000 μg/mL holotransferrin</p> <p>- <strong>Day 0:</strong> 100 μg/mL holotransferrin</p> <p>- <strong>Day 0:</strong> 100 μg/mL holotransferrin + 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 1000 μg/mL apotransferrin</p> <p>- <strong>(empty lane)</strong></p> <p>- <strong>Day 1:</strong> 1000 μg/mL holotransferrin</p> <p>- <strong>Day 1:</strong> 100 μg/mL holotransferrin</p> <p>- <strong>Day 1:</strong> 100 μg/mL holotransferrin + 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 1000 μg/mL apotransferrin</p> <p>- <strong>(empty lane)</strong></p> <p>- <strong>Day 2:</strong> 1000 μg/mL holotransferrin</p> <p>- <strong>Day 2:</strong> 100 μg/mL holotransferrin</p> <p>- <strong>Day 2:</strong> 100 μg/mL holotransferrin + 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 2:</strong> 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 2:</strong> 1000 μg/mL apotransferrin</p> <p>More details on the protocol for western blot available in the manuscript at https://doi.org/10.1101/2021.08.02.454758</p> <p> </p> <p><strong>For Figure 4:</strong></p> <p>Raw uncropped images of the membranes obtained from western blots of cultured erythroblasts derived from two different donors with different iron supplementations (no hTf or Def, 52 μM iron-loaded deferiprone, or 300 μg/mL holotransferrin), showing the phosphorylation level of STAT5 upon withdrawal of erythropoietin (Epo) (3 hours) and restimulation with 0.2 or 1.0 U/mL Epo.</p> <p>After staining, membranes were scanned in an Epson V500 scanner (full color, 1200 dpi, bit depth = 24).</p> <p>For both membranes, the loading order is the same:</p> <p>- <strong>Lane 1:</strong> cells cultured without hTf nor Def, and no Epo restimulation</p> <p>- <strong>Lane 2:</strong> cells cultured with 52 μM iron-loaded deferiprone, and no Epo restimulation</p> <p>- <strong>Lane 3:</strong> cells cultured with 300 μg/mL holotransferrin, and no Epo restimulation</p> <p>- <strong>Lane 4:</strong> cells cultured without hTf nor Def, and restimulation with 0.2 U/mL Epo.</p> <p>- <strong>Lane 5:</strong> cells cultured with 52 μM iron-loaded deferiprone, and restimulation with 0.2 U/mL Epo.</p> <p>- <strong>Lane 6:</strong> cells cultured with 300 μg/mL holotransferrin, and restimulation with 0.2 U/mL Epo.</p> <p>- <strong>Lane 7:</strong> cells cultured without hTf nor Def, and restimulation with 1.0 U/mL Epo.</p> <p>- <strong>Lane 8:</strong> cells cultured with 52 μM iron-loaded deferiprone, and restimulation with 1.0 U/mL Epo.</p> <p>- <strong>Lane 9:</strong> cells cultured with 300 μg/mL holotransferrin, and restimulation with 1.0 U/mL Epo.</p>
Stiffness of Fluid and Gel Phase Lipid Nanovesicles: Weighting the Contributions of Membrane Bending Modulus and Luminal Pressurization
<p>In the manuscript, Atomic Force Microscopy (AFM) is employed for characterizing the mechanical response of nanosized lipid vesicles presenting membranes with different physical state. Results suggest that the mechanical response of lipid vesicles can be ascribed to two main contributions, i) the luminal pressure and ii) the intrinsic membrane rigidity. By developing a spring-based model, authors were able to rationalize the apparent disagrement between the two most commonly employed models for describing vesicle mechanics.</p>
Extended Data Fig. 5 in A new Jurassic scansoriopterygid and the loss of membranous wings in theropod dinosaurs
Extended Data Fig. 5 | Comparisons of hand morphology among Scansoriopterygidae. a–c, Line drawings of the hands of Ambopteryx (a), Epidendrosaurus (b) and Yi (c). Scale bars, 10 mm (a, b), 20 mm (c).
Extended Data Fig. 4 in A new Jurassic scansoriopterygid and the loss of membranous wings in theropod dinosaurs
Extended Data Fig. 4 | Forelimb comparisons between Ambopteryx and Yi. a, Left forelimb of Ambopteryx (IVPP V24192). b–d, Left forelimb (b), right humerus (c) and the right styliform element (d) of Yi (STM 31-2). The proximal margins of the humeri are marked in white dashed lines to show the differences between these two taxa. Abbreviations as in Figs. 1, 2, except for: st, styliform element. Scale bars, 10 mm (a), 20 mm (b–d).
Extended Data Fig. 3 in A new Jurassic scansoriopterygid and the loss of membranous wings in theropod dinosaurs
Extended Data Fig. 3 | Anatomy of Ambopteryx, IVPP V24192. a–d, Interpretative drawings of the neck and pectoral girdle (a), caudal vertebrae and pygostyle (b), left forelimb (c) and pelvis and left hindlimb (d). Abbreviations as in Figs. 1, 2, except for: ca, caudal vertebrae; cm, calcaneum; de, deltopectoral crest of humerus; do, dorsal vertebrae; I–III, metacarpals I–III; ip, iliac peduncle of ilium; mtII–IV, metatarsals II–IV; p1–4, pedal digits I to IV; and st, styliform element. Scale bars, 10 mm (a–d).
Fig. 1 in A new Jurassic scansoriopterygid and the loss of membranous wings in theropod dinosaurs
Fig. 1 | Holotype of A. longibrachium, IVPP V24192. a, b, Photograph (a) and line drawing (b) of the holotype of A. longibrachium (IVPP V24192). as, astragalus; ca, calcaneum; ce, cervical vertebrae; cv, caudal vertebrae; dr, dorsal rib; dv, dorsal vertebrae; ga, gastroliths; gs, gastralia; is, ischium; lc, left coracoid; lf, left femur; lfi, left fibula; lh, left humerus; li, left ilium; lm2, lm3 and lm4, left metatarsals II, III and IV; lmd1, lmd2 and lmd3, left manual digits I, II and III; lr, left radius; ls, left scapula; lt, left tibia; lu, left ulna; mc1, mc2 and mc3, metacarpals I, II and III; nf, neck feathers; pd1, pd2, pd3 and pd4, left pedal digits I, II, III and IV; pu, pubis; py, pygostyle; rc, right coracoid; rh, right humerus; ri, right ilium; rmd3, right manual digit III; rr, right radius; rra, right radiale; rs, right scapula; ru, right ulna; rua, right ulnare; se, styliform element; sk, skull; sv, sacral vertebrae; to, tooth. Brown and dark grey shadings denote feathers and membranous tissues, respectively; blue and light blue shadings indicate the potential bony stomach content; light grey denotes unidentified matrix. Red box indicates the location from which the sample was taken for histological analysis. Scale bars, 10 mm.
Extended Data Figure 3 in A bizarre Jurassic maniraptoran theropod with preserved evidence of membranous wings
Extended Data Figure 3 | Close-ups of the three counter slab fragments and corresponding slab regions of STM 31-2. Top row: isolated piece from counter slab preserving cranial region (left), and corresponding region of slab (right); middle row: isolated piece from counter slab preserving forelimb region (left), and corresponding region of slab (right); bottom row: isolated piece from counter slab preserving hindlimb region (left), and corresponding region of slab (right).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.