Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
818
datasets available to search
ShareScore release 0.9.0
Dataset results
818 results for “neutralization”
Data from: Neutral genetic processes influence MHC evolution in threatened gopher tortoises (Gopherus polyphemus)
Levels of adaptive genetic variation influence how species deal with environmental and ecological change, but these levels are frequently inferred using neutral genetic markers. Major histocompatibility complex (MHC) genes play a key role in the adaptive branch of the immune system and have been used extensively to estimate levels of adaptive genetic variation. Parts of the peptide binding region, sites where MHC molecules directly interact with pathogen and self-proteins, were sequenced from a MHC class I (95/441 tortoises) and class II (245/441 tortoises) gene in threatened and non-threatened populations of gopher tortoises (Gopherus polyphemus), and adaptive genetic variation at MHC genes was compared to neutral genetic variation derived from 10 microsatellite loci (441 tortoises). Genetic diversity at the MHC class II locus and microsatellites was greater in populations in the non-threatened portion of the gopher tortoise's range (MHC class II difference in mean A = 8.11, AR = 0.79, HO = 0.51, and HE = 0.16; microsatellite difference in mean A = 1.05 and AR = 0.47). Only MHC class II sequences showed evidence of positive selection (dN/dS > 1, Z = 1.81, P = 0.04). Historical gene flow as estimated with Migrate-N was greater than recent migration estimated with BayesAss, suggesting that populations were better connected in the past when habitat was less fragmented. MHC genetic differentiation was correlated with microsatellite differentiation (Mantel r = 0.431, P = 0.001) suggesting neutral genetic processes are influencing MHC evolution, and advantageous MHC alleles could be lost due to genetic drift.
Data set for "Tracking the nearfield evolution of an initially shallow, neutrally-buoyant plane jet over a sloping bottom boundary"
Open the record for dataset details and reuse information.
Data of GOES X-ray flux, GRACE neutral density, and TIEGCM Simulation for manuscript "On the Relationship between Traveling Atmospheric Disturbances and Traveling Ionospheric Disturbances"
<p>There are data used in manuscript "On the Relationship between Traveling Atmospheric Disturbances and Traveling Ionospheric Disturbances":</p> <ol> <li>GOES 15 0.1-0.8 nm X-ray flux: "xrsa_g15_20170907-08.mat"</li> <li>GRACE neutral density: "GA_DNS_2017_09_07.mat", "GA_DNS_2017_09_08.mat"</li> <li>Simulation of Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model (TIE‐GCM): other files</li> </ol>
The data set to paper: Hydrolytic instability of laser-ablatively deposited CaSi2 coatings in air and neutral water affects the behavior of bone healing-related cell types
<p>Main message of this study is focused on calcium silicide (CaSi<sub>2</sub>) instability in humid air or pH-neutral water remains unknown, although the topochemical formation of silicene from CaSi<sub>2</sub> in various aqueous phases is a well-known process. The reseach reports on laser ablation of CaSi<sub>2</sub> in the vacuum and ethanol and examine the instability of the deposited coatings in humid air and neutral water. We further investigate the behavior of human mesenchymal stromal cells (hMSCs), vascular cells (HUVECS, human umbilical vein endothelial cells), and macrophages (derived from THP-1 cell line) in contact with the deposited coatings submerged in cell culture medium. </p>
Atmospheric Multiphase Buffering Facilitates Acid-Base Neutralization but Triggers Unexpected Accompanying Pollution
Open the record for dataset details and reuse information.
All data of the manuscript "A self-sustained charge neutrality intracloud lightning parameterization containing channel decay and reactivation" submitted to Geophysical Research Letters
<p>The data support the manuscript entitled "A self-sustained charge neutrality intracloud lightning parameterization containing channel decay and reactivation". Microsoft Notepad can open the *.txt files, they contain the channel information of two intracloud flashes (IC1 and IC2) and the channel elctrical parameters at the first fork of positive or negative leader channels. A normal video player software can open Movie_S1.avi, and it shows the entire development process of IC1 discharge.</p> <p>The data can be used freely for scientific purposes with the appropriate citation.</p>
Carbon neutrality transitions from government-dependent towards free trade autonomy renewable markets with grid-demand-storage synergies
Open the record for dataset details and reuse information.
Figure S1: SARS-CoV-2-specific neutralization activity at days 1 and 8 relative to enrollment in exposed seronegative nasal SIgA positive and infected participants.
Open the record for dataset details and reuse information.
A Predictive Model for the Streamwise Velocity in the Near-neutral Atmospheric Surface Layer
<p>A Predictive Model for the Streamwise Velocity in the Near-neutral Atmospheric Surface Layer</p>
Studying solar storm impact on global neutral wind pattern using WACCM-X numerical simulations and Meteor radar observations
Open the record for dataset details and reuse information.
The Influencing Factors of Carbon Neutral Bonds and Blue Bonds Credit Spreads
Open the record for dataset details and reuse information.
Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP
Antimicrobial peptides (AMPs) are one of the most important defense mechanisms against bacterial infections in insects, plants, non-mammalian vertebrates, and mammals. In the present study, a class of synthetic AMPs was evaluated for anti-inflammatory activity. One cationic AMP, GW-A2, demonstrated the ability to inhibit the expression levels of nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-activated macrophages. GW-A2 reduced LPS-induced increases in the phosphorylation of mitogen-activated protein kinase and protein kinase C-α/δ and the activation of NF-κB. GW-A2 also inhibited NLRP3 inflammasome activation induced by LPS and ATP. Furthermore, in the mice injected with LPS, GW-A2 reduced (1) the concentration of IL-1β, IL-6 and TNF-α in the serum; (2) the concentration of TNF-α in the peritoneal lavage; (3) the expression levels of iNOS, COX-2 and NLRP3 in the liver and lung; (4) the infiltration of polymorphonuclear neutrophils in the liver and lung. The underlying mechanisms for the anti-inflammatory activity of GW-A2 were found to be partially due to LPS and ATP neutralization. These results provide insights into how GW-A2 inhibits inflammation and the NLRP3 inflammasome and provide a foundation for the design of rational therapeutics for inflammation-related diseases.
Data from: Invasive species reduces parasite prevalence and neutralizes negative environmental effects on parasitism in a native mosquito
1.Invasive species research often focuses on direct effects of invasion on native ecosystems and less so on complex effects such as those influencing host‐parasite interactions. However, invaders could have important effects on native host‐parasite dynamics. Where infectious stages are ubiquitous and native host‐pathogen specificity is strong, invasive less‐competent hosts may reduce the pool of infectious stages, effectively reducing native host‐parasite encounter rate. Alternatively, invasive species could alter transmission via changes in native species abundance. 2.Biotic and abiotic environmental factors can also impact disease dynamics by altering host or parasite condition. However, little is known about potential interactive effects of invasion and environmental context on native species disease dynamics. Moreover, experimental examinations of the mechanisms driving dilution effects are limited, but serve to provide tests of predictions leading to diversity‐disease relationships. 3.Using field and laboratory experiments, we tested competing hypotheses that an invasive species reduces the prevalence of a native parasite in its host by removing infectious propagules from the environment or by reducing native host abundance. In addition, we evaluated the role of detritus quantity as a resource base in mediating effects of the invasive species. 4.Native parasite prevalence was reduced when the invasive species was present. Prevalence was also higher in high detritus habitats, although this effect was lost when the invasive species was present. The invasive species significantly reduced infectious propagules from the aquatic habitats. Presence of the invasive species had no effect on the native species abundance; thus, the reduction in parasitism was not due to changes in host density but through a reduction in infectious propagule encounters. 5.We conclude that an invasive species can facilitate a native species by reducing parasite prevalence via a dilution effect and that these effects can be modified by resource level. Reductions in parasitism may have ripple effects throughout the community, altering the strength of competitive interactions, predation rates, or coinfection with other pathogens. We advocate considering potential positive effects of invasive species on recipient communities, in addition to effects of invasions on host‐parasite interactions to gain a broader understanding of the complex consequences of invasion.
Data from: Evaluation of demographic history and neutral parameterization on the performance of Fst outlier tests
FST outlier tests are a potentially powerful way to detect genetic loci under spatially divergent selection. Unfortunately, the extent to which these tests are robust to non-equilibrium demographic histories has been under-studied. We developed a landscape-genetics simulator to test the effects of isolation by distance (IBD) and range expansion on FST outlier methods. We evaluated the two most commonly used methods for the identification of FST outliers (FDIST2 and BayeScan, which assume samples are evolutionarily independent) and two recent methods (FLK and Bayenv2, which estimate and account for evolutionary non-independence). Parameterization with a set of neutral loci ("neutral parameterization") always improved the performance of FLK and Bayenv2, while neutral parameterization caused FDIST2 to actually perform worse in the cases of IBD or range expansion. BayeScan was improved when the prior odds on neutrality was increased, regardless of the true odds in the data. On their best performance, however, the widely-used methods had high false-positive rates for IBD and range expansion and were outperformed by methods that accounted for evolutionary non-independence. In addition, default settings in FDIST2 and BayeScan resulted in many false positives under balancing selection. However, all methods did very well if a large set of neutral loci is available to create empirical p-values. We conclude that in species that exhibit IBD or have undergone range expansion, many of the published FST outliers based on FDIST2 and BayeScan are probably false positives, but FLK and Bayenv2 show great promise for accurately identifying loci under spatially-divergent selection.
Data from: Evolution of a dominant natural isolate of Escherichia coli in the human gut over the course of a year suggests a neutral evolution with reduced effective population size
In vitro and in vivo evolution experiments on Escherichia coli revealed several principles of bacterial adaptation. However, few data are available in the literature describing the behavior of E. coli in its natural environment. We attempted here to study the evolution in the human gut of a commensal dominant E. coli clone ED1a belonging to B2 phylogroup, through a longitudinal genomic study. We sequenced 24 isolates sampled at three different time points within a healthy individual over almost a year. We computed amutation rate of 6.90x10-7 per base per year of the chromosome for E. coli ED1a in healthy human gut. We observed a very limited genomic diversity, and could not detect any evidence of selection contrary to what is observed in experimental evolution over similar length of time. We therefore suggest that ED1a being well adapted to the healthy human gut evolves mostly neutrally with a low effective population size (Ne ≈ 500 – 1700).
Dataset associated to: Nanoscaffold effects on the performance of air-cathodes for microbial fuel cells: Sustainable Fe/N-carbon electrocatalysts for the oxygen reduction reaction under neutral pH conditions
<p>This file contains the dataset associated to the published research article "Nanoscaffold effects on air-cathode performance in microbial fuel cells: Fe/N-carbon electrocatalysts for the oxygen reduction reaction under neutral pH conditions". The dataset contains X-ray powder diffraction, Inductively Coupled Plasma Emission Spectroscopy, elemental analysis, measurements of the specific surface area, transmission electron microscopies, x-ray photoelectron microscopy, electrochemistry and microbial fuel cells power outputs data from their relative instruments. This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreements No. 799175 (HiBriCarbon) and No. 748968 (EDGE-FREEMAB). The results of this publication reflect only the authors' view and the Commission is not responsible for any use that may be made of the information it contains. This publication has also emanated from research conducted with the financial support of Science Foundation Ireland under Grant No. 13/CDA/2213 and 19/FFP/6761. SI kindly acknowledges support by the Department of Social Justice State Government of Maharashtra, India. </p>
The synergetic mitigation benefits on carbon and mercury emissions from carbon neutrality strategies and the Minamata Convention
<p>Results data</p>
The synergetic mitigation benefits on carbon and mercury emissions from carbon neutrality strategies and the Minamata Convention.
<p>This is the result of our paper data.</p>
Datasets for "Characterization of a DC glow discharge in N2-H2 with electrical measurements and neutral and ion mass spectrometry" and "Interaction dust – plasma in Titan's ionosphere: feedbacks on the gas phase composition"
<p>Dataset for the two following papers:</p> <p>-Audrey Chatain, Ana-Sofia Morillo Candas, Ludovic Vettier, Nathalie Carrasco, Guy Cernogora, and Olivier Guaitella, Characterization of a DC glow discharge in N<sub>2</sub>-H<sub>2</sub> with electrical measurements and neutral and ion mass spectrometry, Plasma Sources Science and Technology (2023), vol. 32, 035002. DOI: <a href="https://doi.org/10.1088/1361-6595/acc132">10.1088/1361-6595/acc132</a>. Open access: <a href="http://arxiv.org/abs/2303.01883">arXiv:2303.01883</a>.</p> <p>-Audrey Chatain, Nathalie Carrasco, Ludovic Vettier, and Olivier Guaitella, Interaction dust – plasma in Titan’s ionosphere: feedbacks on the gas phase composition, Icarus (2023), vol. 396, 115502. DOI: <a href="https://doi.org/10.1016/j.icarus.2023.115502">10.1016/j.icarus.2023.115502</a>. Open access: <a href="https://arxiv.org/abs/2303.00062">arXiv:2303.00062</a>.</p> <p>It contains raw data (from electric and mass spectrometry measurements), Matlab codes to process the data, processed Matlab variables, Matlab codes to plot the data and Matlab figures corresponding to the figures in the papers.</p> <p> </p>
Empty micelle - 60 SDS - Na neutralized - CHARMM36m - 293K - TIP4P-2005 water model
<p>Empty micelle simulation to investigate the effect of water model and peptide on SRD.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.