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4,489
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ShareScore release 0.9.0
Dataset results
4,489 results for “transitivity”
Dynamic alteration of cancer stem cell regulators in glioblastoma through radiation-induced mesenchymal transition
GEO Series GSE113149. Homo sapiens. 4 samples. Type: Expression profiling by array.
VEGF/ERK activation and PI3K inhibition together drive a vein-to-artery transition in an in vitro model of human angiogenesis
GEO Series GSE312764. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide distribution analysis of RNA Helicase Maleless (MLE) in Drosophila Melanogaster early male embryo, before (0-2 Hr) and after (2-4 Hr) maternal to zygotic transition (MZT) and in absence of
GEO Series GSE174781. Drosophila melanogaster. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Maintenance of cell fate by the Polycomb Group gene Sex combs extra enables a partial epithelial mesenchymal transition in Drosophila
GEO Series GSE153905. Drosophila melanogaster. 22 samples. Type: Other.
PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration [Xenium]
GEO Series GSE267680. Homo sapiens. 5 samples. Type: Other.
CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal transition-like transcriptional activation
GEO Series GSE68538. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Oleanolic acid inhibits epithelial–mesenchymal transition of hepatocellular carcinoma by promoting iNOS dimerization
GEO Series GSE120311. Homo sapiens. 2 samples. Type: Expression profiling by array.
Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis.
GEO Series GSE178615. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Data for publication "Transcriptional and functional profiling of Endothelial Colony Forming Cells identifies inflammation and endothelial to mesenchymal transition as drivers for phenotypic heterogeneity"
<p>Here, the data is stored for the article "Transcriptional and functional profiling of Endothelial Colony Forming Cells identifies inflammation and endothelial to mesenchymal transition as drivers for phenotypic heterogeneity" which is currently submitted but not accepted.</p><p>it was not possible to include all data in this repository. the confocal tilescan images used for WPB and Cell morphology quantification and images used for the migration assay were too many and too large in size to include. However, this data is available upon request.</p>
Global estimates of the storage and transit time of water through vegetation
Open the record for dataset details and reuse information.
Dataset related to the article "Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype"
<p>This record contains raw data related to the article "Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype"</p> <p><strong><em>Aims:</em></strong> During calcific aortic valve stenosis (CAVS) progression, oxidative stress and endothelial dysfunction mark the initial pathogenic steps with a parallel dysregulation of the antioxidant systems. Here, we tested whether oxidation-induced protein S-glutathionylation (P-SSG) accounts for a phenotypic switch in human aortic valvular tissue, eventually leading to calcium deposition. Next, we tested whether countering this reactive oxygen species (ROS) surge would prevent these perturbations. <strong><em>Results:</em></strong> We employed state-of-the-art technologies, such as electron paramagnetic resonance (EPR), liquid chromatography-tandem mass spectrometry, imaging flow-cytometry, and live-cell imaging on human excised aortic valves and primary valve endothelial cells (VECs). We observed that a net rise in EPR-detected ROS emission marked the transition from fibrotic to calcific in human CAVS specimens, coupled to a progressive increment in P-SSG deposition. In human VECs (hVECs), treatment with 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid triggered highly oxidizing conditions prompting P-SSG accumulation, damaging mitochondria, and inducing endothelial nitric oxide synthase uncoupling. All the events conjured up in morphing these cells from their native endothelial phenotype into a damaged calcification-inducing one. As proof of principle, the use of the antioxidant N-acetyl-L-cysteine prevented these alterations. <strong><em>Innovation:</em></strong> Borne as a compensatory system to face excessive oxidative burden, with time, P-SSG contributes to the morphing of hVECs from their innate phenotype into a damaged one, paving the way to calcium deposition. <strong><em>Conclusion:</em></strong> Our data suggest that, in the human aortic valve, unremitted ROS emission along with a P-SSG build-up occurs and accounts, at least in part, for the morphological/functional changes leading to CAVS.</p>
Does the Synergy Model Implementation Improve the Transition from In-Hospital to Primary Care? The Experience from an Italian Cardiac Surgery Unit, Perspectives, and Future Implications
<p>Dellafiore F, Caruso R, Nania T, Pittella F, Fiorini T, Caruso MP, Zaffino G, Stievano A, Arrigoni C. Does the Synergy Model Implementation Improve the Transition from In-Hospital to Primary Care? The Experience from an Italian Cardiac Surgery Unit, Perspectives, and Future Implications. Int J Environ Res Public Health. 2022 May 5;19(9):5624. doi: 10.3390/ijerph19095624. PMID: 35565012; PMCID: PMC9105911.</p> <p>Abstract</p> <p>The demand for care services in the healthcare system has changed and is triggering a smooth transition from in-hospital to primary care. In this regard, patient-centered-care models of care delivery might provide a framework to follow patients' journeys throughout their transition between different levels of care. Accordingly, an Italian research group at a cardiac hospital in Northern Italy implemented the Synergy Model in a Cardiac Surgery Unit, a patient-centered-care model, and is using the framework of the model to guide a smooth transition of patients towards rehabilitation and primary care after their hospitalization. This discursive paper is focused on the experience, perspectives, and future implications of adopting the Synergy Model to facilitate the transition from in-hospital to primary care. The presented experience and discussion might be helpful to the international debate regarding the strategies to boost a smooth transition from in-hospital to primary care.</p>
Dataset to "Fluorescence Bar-coding and Flowmetry based on Dark State Transitions in Fluorescence Emitters"
<p><strong>This folder contains all raw data underlying the results presented in a manuscript, submitted for publication to <em>Journal of Physical Chemistry B</em>, and entitled:</strong></p> <p><strong>Fluorescence Bar-coding and Flowmetry based on Dark State Transitions in Fluorescence Emitters</strong></p> <p> </p> <p><strong>Authored by:</strong></p> <p>B. Demirbay‡, E. Sandberg‡, J. Piguet, J. Widengren*</p> <p>Royal Institute of Technology (KTH), Experimental Biomolecular Physics, Dept. Applied Physics, Albanova University Center 106 91 Stockholm, Sweden</p> <p>‡Contributed equally.</p> <p>*Corresponding Author:</p> <p> Email: <a href="mailto:jwideng@kth.se">jwideng@kth.se</a>, Phone: +46-8-7907813</p> <p> </p> <p><strong>The data files are grouped into the different techniques used to generate them, and refer to the figures/tables in the manuscript where the extracted results are presented.</strong></p> <p> </p> <p><strong>ABSTRACT</strong></p> <p>Reversible dark state transitions in fluorophores represent a limiting factor in fluorescence-based ultrasensitive spectroscopy, is a necessary basis for fluorescence-based super-resolution imaging, but may also offer additional, largely orthogonal fluorescence-based readout parameters. In this work, we analyzed the blinking kinetics of Cyanine5 (Cy5) as a bar-coding feature distinguishing Cy5 from rhodamine fluorophores having largely overlapping emission spectra. First, fluorescence correlation spectroscopy (FCS) solution measurements on mixtures of free fluorophores and fluorophore-labeled small unilamellar vesicles (SUVs) showed that Cy5 could be readily distinguished from the rhodamines by its reversible, largely excitation-driven <em>trans-cis</em> isomerization. This was next confirmed by transient state (TRAST) spectroscopy measurements, determining the fluorophore dark state kinetics in a more robust manner, from how the time-averaged fluorescence intensity varies upon modulation of the applied excitation light. TRAST was then combined with wide-field imaging of live cells, whereby Cy5 and rhodamine fluorophores could be distinguished on a whole cell level, as well as in spatially resolved, multiplexed images of the cells. Finally, we established a microfluidic TRAST concept, and showed how different mixtures of free Cy5 and rhodamine fluorophores and corresponding fluorophore-labeled SUVs could be distinguished on-the-fly when passing through a microfluidic channel. In contrast to FCS, TRAST does not rely on single-molecule detection conditions or a high time-resolution and is thus broadly applicable on different biological samples. Therefore, we expect that the bar-coding concept presented in this work can offer an additional, useful strategy for fluorescence-based multiplexing, implementable on a broad range of both stationary and moving samples.</p>
Transition metal ions as a new therapeutic target for cardiac light chain amyloidosis
<p>This dataset comprises raw data related to the study “Transition metal ions as a new therapeutic target for cardiac light chain amyloidosis”, aimed at investigating the <em>in vitro </em>and <em>in vivo</em> role of transition metal ions in the redox process underlying LC cardiotoxicity. This research was funded by Italian Ministry of Health (Ricerca Finalizzata RF-2016-02361756 to Prof. Giovanni Palladini).</p>
CHLORELLA, chloroplast-targeted long noncoding RNA, mediates the chloroplast functional transition during leaf lifespan through anterograde signaling pathway
GEO Series GSE255867. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription
GEO Series GSE196653. Mus musculus. 37 samples. Type: Expression profiling by high throughput sequencing.
Hypoxia inhibits HUNK-mediated phosphorylation of GEF-H1 for epithelial-to-mesenchymal transition
GEO Series GSE203440. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
TCF21 orchestrates epithelial-to-mesenchymal transition and cytoskeleton reorganization in uterine development and endometriosis
GEO Series GSE282592. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Spheroid growth in ovarian cancer promotes gene expression involved in epithelial-mesenchymal transition, stem cell promotion, and multiple stress responses
GEO Series GSE80373. Homo sapiens. 8 samples. Type: Expression profiling by array.
MiRNA-mediated induction of mesenchymal-to-epithelial transition (MET) between cancer cell types is significantly modulated by inter-cellular molecular variability
GEO Series GSE130402. Homo sapiens. 45 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.